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Pathways to Cancer Therapeutics

癌症治疗途径

基本信息

批准号：
10478975
负责人：
Carolyn M Price
金额：
$ 43.65万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10478975
关键词：
Malignant Neoplasms Pathway interactions Therapeutic

项目摘要

Project Summary The opportunities for new and targeted approaches to cancer treatment are growing at an exponential pace. However, to effectively harness these opportunities requires a pool of researchers who can bridge the divide between lab-based identification of new therapeutic approaches and actual clinical needs and practicalities of patient treatment. Currently the pool of individuals with such skills is limited. The Pathways to Cancer Therapeutics Training Program seeks to address this shortfall by increasing the number of individuals with a strong training in the areas of cancer biology that underlie identification of new therapeutic approaches, who also have a true understanding of the challenges and needs associated with translating scientific discovery into the clinic. The Training Program has two key goals: The first is to provide pre- and postdoctoral trainees with a rigorous and applied understanding of how basic research in cancer biology can be utilized to identify new drug targets and more effective therapeutic strategies. The second is to provide the trainees with an understanding of the challenges and practice of using cancer therapeutics in the clinic. The training will focus on three areas that are key to development of new therapeutic approaches and are areas of institutional strength in cancer therapy: cancer metabolism, tumor immunology and the microenvironment, and genome instability and regulation. A series of multidisciplinary activities are proposed to achieve the goals of the Program. (1) Trainees will participate in a mentored research project under the direction of one of 26 primary mentors who come from 10 basic science and clinical departments across the University of Cincinnati (UC) and Cincinnati Children’s Medical Center (CCHMC). The mentors have active, well-funded research programs and extensive mentoring experience. (2) Trainees undertake formal training that includes didactic coursework, attending seminars, ethics training and career development activities. The specialized classes lead to a Certificate in Clinical and Translational Research. (3) Trainees participate in activities in clinical oncology. Each trainee is paired with a clinical co-mentor with expertise related to the trainee’s research area. The clinical co-mentor participates in the development of the trainee research project and career plan. In addition, trainees attend Tumor Boards/Grand Rounds and participate in clinical shadowing experiences with their co-mentor. The Training Program is administered by Co-Principal Investigators and a Clinical Director with support from business offices within UC. Three administrative committees provide program evaluation and oversight, support a rigorous trainee selection process, ensure excellence in training, monitor trainee progress and ensure that trainees represent an ethnically and scientifically diverse group. There is a strong institutional commitment to the Training Program in the form of direct financial support, trainee benefits and administrative support. Institutional programs and Training Program mentors and trainees are actively involved in recruitment of underrepresented groups. The Training Program requests support from the NIH for 6 postdoctoral and 2 predoctoral trainees.

项目摘要新的和有针对性的癌症治疗方法的机会正在以指数级的速度增长。然而，为了有效地利用这些机会，需要一批能够弥合分歧的研究人员新治疗方法的实验室鉴定与实际临床需求和耐心治疗。目前，拥有这种技能的人才库有限。通往癌症之路治疗学培训计划旨在通过增加具有以下特征的个人数量来解决这一不足：在确定新治疗方法的基础上，在癌症生物学领域进行了强有力的培训，真正了解将科学发现转化为诊所培训计划有两个主要目标：第一是为博士前和博士后学员提供一个对如何利用癌症生物学基础研究来识别新药有严格的应用理解更有效的治疗策略。二是为学员提供理解在临床上使用癌症疗法的挑战和实践。培训将侧重于三个方面这是开发新的治疗方法的关键，也是癌症研究机构的优势领域。治疗：癌症代谢，肿瘤免疫学和微环境，基因组不稳定性，调控为实现该方案的目标，提出了一系列多学科活动。(1)学员将参加一个指导研究项目的指导下，26个主要导师谁来自辛辛那提大学（UC）和辛辛那提儿童医院的10个基础科学和临床部门医疗中心（CCHMC）。导师们有积极的、资金充足的研究项目和广泛的指导体验. (2)受训人员接受正式培训，包括教学课程、参加研讨会、道德操守和培训和职业发展活动。专业课程导致临床证书，翻译研究。(3)学员参加临床肿瘤学活动。每个学员都有一个临床合作导师，具有与受训者研究领域相关的专业知识。临床共同导师参与制定受训人员研究项目和职业规划。此外，受训人员参加肿瘤委员会/大与他们的共同导师一起查房并参与临床跟踪体验。培训计划是由共同主要研究者和临床总监在UC内部业务办公室的支持下进行管理。三个行政委员会提供项目评估和监督，支持严格的培训生选拔过程，确保培训的卓越性，监测受训人员的进展，并确保受训人员在族裔上代表和科学多样性的群体。对培训方案有一个强有力的机构承诺，直接的财政支持、培训生福利和行政支持。机构方案和培训方案指导人员和受训人员积极参与招聘代表性不足的群体。培训该计划要求NIH为6名博士后和2名博士前学员提供支持。

项目成果

期刊论文数量（102）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells.

DOI：
10.1016/j.molmed.2016.06.003
发表时间：
2016-08
期刊：
Trends in molecular medicine
影响因子：
13.6
作者：
Akunuru S;Geiger H
通讯作者：
Geiger H

Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting.

DOI：
10.1007/s00401-011-0905-0
发表时间：
2012-03
期刊：
Acta neuropathologica
影响因子：
12.7
作者：
Kalamarides M;Acosta MT;Babovic-Vuksanovic D;Carpen O;Cichowski K;Evans DG;Giancotti F;Hanemann CO;Ingram D;Lloyd AC;Mayes DA;Messiaen L;Morrison H;North K;Packer R;Pan D;Stemmer-Rachamimov A;Upadhyaya M;Viskochil D;Wallace MR;Hunter-Schaedle K;Ratner N
通讯作者：
Ratner N

Selenium suppresses leukemia through the action of endogenous eicosanoids.

DOI：
10.1158/0008-5472.can-13-3694
发表时间：
2014-07-15
期刊：
Cancer research
影响因子：
11.2
作者：
Gandhi UH;Kaushal N;Hegde S;Finch ER;Kudva AK;Kennett MJ;Jordan CT;Paulson RF;Prabhu KS
通讯作者：
Prabhu KS

BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of β-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis.