Conference Proposal to support FASEB Conference on Ciliate Molecular Biology

描述：本申请为“第十三届纤毛分子生物学国际会议”寻求部分资金支持，该会议将于2007年7月21日至26日在亚利桑那州图森举行，作为FASEB夏季研究会议。会议将汇集来自不同国家的120-150名科学家，他们采用分子方法研究以纤毛原生动物为模型系统的各种生物学问题。历史上，对纤毛原生动物的研究导致了许多关于普遍生物过程的关键发现。这些发现包括自剪接RNA、端粒酶和组蛋白乙酰转移酶对染色质的重塑。最近，对纤毛虫的研究为发育过程中的程序性DNA缺失和染色质重塑提供了新的见解。全基因组序列的可用性，优秀的传统和分子遗传学，以及RNA干扰等分子工具的持续发展，使纤毛虫成为研究与各种真核生物（包括人类）共享的众多生物过程的优秀模型。本次会议旨在通过汇集来自不同领域的研究人员，促进未发表的研究成果和技术进步的有效交流，这些研究人员因使用纤毛虫作为模式生物而团结起来。会议将包括九个平台会议、三个研讨会和两个海报会议。平台会议的主题代表了当前纤毛虫研究的活跃领域，包括基因组结构和组织，基因组重排的表观遗传调控，基因组稳定性和动力学，细胞骨架和细胞运动，以及进化和群体生物学。研讨会将以基因组学和后基因组学、新工具和纤毛虫为主题。在过去的会议上，类似的事件是启动和成功完成基因组测序项目的原因，这些项目对该领域有巨大的好处。该领域尽一切努力促进青年科学家、妇女和少数民族的参与。为此，从NIH获得的资金将用于支持学生、博士后和初级研究人员的出席。不用于支付高级调查人员（包括发言人）的费用，他们可以自己支付费用。申请资助10名学生或博士后参加2007年FASEB纤毛虫分子生物学会议的注册费。本次会议汇集了使用单细胞原生动物作为模式生物研究各种健康相关问题的研究人员。对这些生物的研究取得了突破性的发现，大大提高了我们对许多人类疾病的理解，包括癌症和与衰老有关的疾病。

DESCRIPTION: This application seeks partial financial support for the "Thirteenth International Meeting on Ciliate Molecular Biology," which will be held as a FASEB Summer Research Conference at in Tucson Arizona from July 21-26, 2007. The meeting will bring together 120-150 scientists from a variety of countries, who employ molecular approaches to investigate diverse biological problems using ciliated protozoa as their model system. Historically, work on ciliated protozoa has led to a number of key discoveries about universal biological processes. These include the discovery of self-splicing RNA, telomerase, and chromatin remodeling by histone acetyltransferases. Recently, the study of ciliates has provided novel insights into programmed DNA deletion and chromatin remodeling during development. The availability of full genome sequences, excellent traditional and molecular genetics, and the continued development of molecular tools such as RNA interference, make ciliates excellent models for studying numerous biological processes shared with a wide variety of eukaryotic organisms, including humans. This meeting seeks to foster the efficient exchange of unpublished research results and technical advances by bringing together investigators from different fields, who are united by their use of ciliates as model organisms. The conference will include nine platform sessions, three workshops and two poster sessions. Topics of the platform sessions represent active areas of current ciliate research including Genome structure and Organization, Epigenetic Regulation of Genome Rearrangements, Genome Stability and Dynamics Cytoskeleton and Cell Motility, and Evolution and Population Biology. The workshops will be on Genomics and Postgenomics, New Tools and Ciliates in the Classroom. Similar events at past meetings were responsible for initiation and successful completion of genome sequencing projects that have been of enormous benefit to the field. The field makes every effort to promote participation by young scientists, women and minorities. To this end, funding obtained from the NIH will be used to support attendance by students, postdocs and beginning investigators. It will not be used to pay the expenses of senior investigators (including speakers) who can pay their own way. Funds are requested to pay the registration fees for 10 students or postdoctoral fellows so they may attend the 2007 FASEB Conference on Ciliate Molecular Biology. This conference brings together researchers who study a wide variety of health-related problems using single cell protozoa as a model organism. Research with these organisms has resulted in groundbreaking discoveries that have significantly advanced our understanding of a number of human diseases including cancer and diseases related to aging.