Conference Proposal to support FASEB Conference on Ciliate Molecular Biology

描述：本申请寻求对“第十三届国际纤毛虫分子生物学会议”的部分资金支持，该会议将于2007年7月21-26日在亚利桑那州图森市作为FASEB夏季研究会议举行。这次会议将汇集来自不同国家的120-150名科学家，他们使用分子方法以纤毛原生动物作为他们的模型系统来研究各种生物学问题。从历史上看，对纤毛原生动物的研究已经导致了关于普遍生物过程的一些关键发现。这些包括发现自剪接的RNA、端粒酶和组蛋白乙酰转移酶对染色质的重塑。最近，对纤毛虫的研究为研究发育过程中程序性DNA缺失和染色质重塑提供了新的见解。全基因组序列的可获得性，优秀的传统和分子遗传学，以及RNA干扰等分子工具的不断发展，使纤毛虫成为研究包括人类在内的各种真核生物共有的众多生物学过程的极佳模型。这次会议旨在通过将不同领域的研究人员聚集在一起，促进未发表的研究成果和技术进步的有效交流，这些研究人员因使用纤毛虫作为模式生物而团结在一起。大会将包括九个平台会议、三个研讨会和两个海报会议。平台会议的主题代表了当前纤毛虫研究的活跃领域，包括基因组结构和组织、基因组重排的表观遗传调控、基因组稳定性和动力学、细胞骨架和细胞运动以及进化和种群生物学。工作坊将讨论基因组学和后基因组学，课堂上的新工具和纤毛虫。过去会议上的类似活动是启动和成功完成基因组测序项目的原因，这些项目为该领域带来了巨大的好处。该领域尽一切努力促进青年科学家、妇女和少数群体的参与。为此，从NIH获得的资金将用于支持学生、博士后和初级调查人员的出席。它不会被用来支付高级调查人员(包括发言人)的费用，他们可以自己支付。申请资金支付10名学生或博士后研究员的注册费，以便他们可以参加2007年FASEB纤毛虫分子生物学会议。这次会议聚集了研究人员，他们使用单细胞原生动物作为模式生物来研究各种与健康有关的问题。对这些生物的研究取得了突破性的发现，极大地促进了我们对包括癌症和与衰老有关的疾病在内的许多人类疾病的理解。

DESCRIPTION: This application seeks partial financial support for the "Thirteenth International Meeting on Ciliate Molecular Biology," which will be held as a FASEB Summer Research Conference at in Tucson Arizona from July 21-26, 2007. The meeting will bring together 120-150 scientists from a variety of countries, who employ molecular approaches to investigate diverse biological problems using ciliated protozoa as their model system. Historically, work on ciliated protozoa has led to a number of key discoveries about universal biological processes. These include the discovery of self-splicing RNA, telomerase, and chromatin remodeling by histone acetyltransferases. Recently, the study of ciliates has provided novel insights into programmed DNA deletion and chromatin remodeling during development. The availability of full genome sequences, excellent traditional and molecular genetics, and the continued development of molecular tools such as RNA interference, make ciliates excellent models for studying numerous biological processes shared with a wide variety of eukaryotic organisms, including humans. This meeting seeks to foster the efficient exchange of unpublished research results and technical advances by bringing together investigators from different fields, who are united by their use of ciliates as model organisms. The conference will include nine platform sessions, three workshops and two poster sessions. Topics of the platform sessions represent active areas of current ciliate research including Genome structure and Organization, Epigenetic Regulation of Genome Rearrangements, Genome Stability and Dynamics Cytoskeleton and Cell Motility, and Evolution and Population Biology. The workshops will be on Genomics and Postgenomics, New Tools and Ciliates in the Classroom. Similar events at past meetings were responsible for initiation and successful completion of genome sequencing projects that have been of enormous benefit to the field. The field makes every effort to promote participation by young scientists, women and minorities. To this end, funding obtained from the NIH will be used to support attendance by students, postdocs and beginning investigators. It will not be used to pay the expenses of senior investigators (including speakers) who can pay their own way. Funds are requested to pay the registration fees for 10 students or postdoctoral fellows so they may attend the 2007 FASEB Conference on Ciliate Molecular Biology. This conference brings together researchers who study a wide variety of health-related problems using single cell protozoa as a model organism. Research with these organisms has resulted in groundbreaking discoveries that have significantly advanced our understanding of a number of human diseases including cancer and diseases related to aging.