Ultra-fast cerebral blood flow imaging for quantifying brain dynamics

用于量化大脑动态的超快速脑血流成像

• 批准号: 10481324
• 负责人: Jia Guo
• 金额: $ 62.33万
• 依托单位: UNIVERSITY OF CALIFORNIA RIVERSIDE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-08 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10481324
• 关键词: Aging; Blood; Brain; Brain region; Cerebrovascular Circulation; Cerebrum; Complex; Coupled; Detection; Development; Disease; Functional Magnetic Resonance Imaging; Goals; Health; Human; Image; Imaging Device; Individual; Label; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Metabolism; Methods; Modeling; Neurosciences; Neurosciences Research; Noise; Oxygen; Pattern; Performance; Physiologic pulse; Physiological; Relaxation; Rest; Signal Transduction; Site; Time; United States National Institutes of Health; Work; arterial spin labeling; base; blood flow measurement; blood oxygen level dependent; brain parenchyma; brain tissue; cerebral blood volume; connectome; design; hemodynamics; imaging modality; improved; metabolic rate; novel; quantitative imaging; relating to nervous system; response; temporal measurement

Abstract/Project Summary Blood oxygenation level dependent (BOLD) fMRI is widely used in neuroscience studies. Technical advancement in the recently years has enabled BOLD signals to be acquired at sub-second temporal resolution, opening a new window for examining functional dynamics of the human brain, e.g. resting- state fMRI. The BOLD signal originates from the mismatch between cerebral blood flow (CBF) and metabolism changes, and is complex; it serves as an indirect measure of neural activities. A direct observation of CBF changes can provide information that is more closely coupled to neural activities. Arterial spin labeling (ASL) fMRI measures CBF changes noninvasively and quantitatively, therefore may provide valuable dynamic information that is not readily measured with BOLD alone. Currently the existing ASL fMRI methods are limited by low temporal resolution and signal-to-noise ratio (SNR), mainly due to acquisition delays required for the labeled blood to reach the brain tissue. Velocity- selective (VS) ASL shows promises in reducing the delays, but the existing labeling strategies are not optimal for imaging CBF at high temporal resolution, such as below 2 s, or do not have sufficient coverage of the brain. In this proof-of-concept development project, we propose a completely new VS labeling strategy to overcome the problems of existing labeling methods, aiming for functional CBF measurements with substantially increased temporal resolution (~ 1.5 s), SNR efficiency and a good coverage. The ultra-fast and quantitative CBF imaging method developed in this project should help advance our understanding of brain dynamics under healthy and diseased conditions, and may be an imaging tool of choice for individual comparison and/or longitudinal studies.

摘要/项目摘要 血氧水平依赖(BOLD)功能磁共振成像广泛应用于神经科学研究。技术 近年来的进步使得能够在亚秒级的时间内获取大胆的信号 分辨率，为研究人脑的功能动力学打开了一个新的窗口，例如休息- 州功能性核磁共振检查。BOLD信号源于脑血流量(CBF)和 新陈代谢的变化是复杂的；它是神经活动的间接衡量标准。一位直接的 观察脑血流量的变化可以提供与神经活动更密切相关的信息。 动脉自旋标记(Asl)功能磁共振成像无创性和定量地测量了脑血流量的变化。 可能会提供有价值的动态信息，而这些信息不容易仅用粗体来衡量。目前 现有的ASL fMRI方法受时间分辨率和信噪比(SNR)低的限制， 主要是由于标记血液到达脑组织所需的采集延迟。速度- 选择性(VS)ASL在减少延迟方面表现出了希望，但现有的标签策略并不是 最适合在高时间分辨率下成像脑血流，如S 2以下，或没有足够的 大脑的覆盖面。在这个概念验证开发项目中，我们提出了一个全新的VS 针对功能性CBF的标记策略，克服现有标记方法存在的问题 测量结果具有较大的时间分辨率(~1.5%S)，信噪比效率高，效果良好 覆盖范围。本项目开发的超快速定量脑血流成像方法将有助于 促进我们对健康和疾病条件下的大脑动力学的理解，并可能是一种 个人比较和/或纵向研究的首选成像工具。

项目成果

Robust dual-module velocity-selective arterial spin labeling (dm-VSASL) with velocity-selective saturation and inversion.

具有速度选择性饱和度和反转的稳健双模型速度选择性动脉自旋标记（DM-VSASL）。

• DOI: 10.1002/mrm.29513
• 发表时间: 2023-03
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: Guo, Jia

Recent Technical Developments in ASL: A Review of the State of the Art.

• DOI: 10.1002/mrm.29381
• 发表时间: 2022-11
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: Hernandez-Garcia, Luis;Aramendia-Vidaurreta, Veronica;Bolar, Divya S.;Dai, Weiying;Fernandez-Seara, Maria A.;Guo, Jia;Madhuranthakam, Ananth J.;Mutsaerts, Henk;Petr, Jan;Qin, Qin;Schollenberger, Jonas;Suzuki, Yuriko;Taso, Manuel;Thomas, David L.;van Osch, Matthias J. P.;Woods, Joseph;Yan, Lirong;Wang, Ze;Zhao, Li;Zhao, Moss Y.;Okell, Thomas W.
• 通讯作者: Okell, Thomas W.

Optimizing background suppression for dual-module velocity-selective arterial spin labeling: Without using additional background-suppression pulses.

优化双模块速度选择性动脉自旋标记的背景抑制：不使用额外的背景抑制脉冲。

• DOI: 10.1002/mrm.29995
• 发表时间: 2024
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Guo,Jia