Biostatistics and Bioinformatics Core

项目总结 生物统计学和生物信息学核心(共享资源) 联合领导：埃里克·A·罗斯博士(联席领导)HC：Konstantinos Krampis博士(联合领导) 生物统计和生物信息学核心(BBC)的总体目标是促进癌症 通过提供专家实验设计，在TUfcc和HC进行差异研究， TUfcc/HC癌症的生物信息学、数据管理、基因组学和数据分析支持 合伙科学家。核心成员拥有丰富的知识和经验， 应用于癌症研究的生物统计学、生物信息学、基因组学和流行病学。这 高度互动的生物统计学家、生物信息学家、信息学家、遗传学家和 流行病学家将为所有伙伴关系项目、试点研究和核心项目提供服务，并支持未来 项目和试点研究。 生物统计和生物统计核心的具体目标是：(1)提供专家 TUfcc/HC癌症伙伴关系调查人员在严格设计 实验和研究，包括研究方案的制定、样本量的确定、 中期审查和最终审查的随机化程序、实验方法和计划 分析。(2)对TUfcc/HC癌进行统计和生物信息学分析 伙伴关系调查员使用适当的统计和计算方法以及 协助调查人员撰写手稿的统计和生物信息学部分 以及对结果的解释和陈述。(3)提供信息学工具，提升 TUfcc/HC癌症伙伴关系研究。在HC建立癌症研究能力，通过提供 人力资源中心的研究人员拥有便利数据输入、存储和检索的信息系统。(4) 提供经济高效、高质量的基因组和表观遗传学服务和专业知识 TUfcc/HC癌症伙伴关系包括NextGen测序(例如，DNA-Seq、RNA-Seq)AS 良好的细胞遗传学分析、染色体和表达微阵列解决方案。(5) 使可能是非技术用户的TUfcc/HC调查人员能够轻松访问和 通过用户管理大规模基因组数据集和运行生物信息学数据管道- 友好的Web浏览器可访问界面。 通过向研究人员提供定量和基因组学专业知识和资源，并分享 技术能力，BBC团队将支持整个TUfcc/HC癌症伙伴关系 并促进项目目标的实现和超出规定的探索性分析。

PROJECT SUMMARY Biostatistics and Bioinformatics Core (Shared Resource) TUFCCC: Eric A. Ross, PhD (Co-Leader) HC: Konstantinos Krampis, PhD (Co-Leader) The overall goal of the Biostatistics and Bioinformatics Core (BBC) is to facilitate cancer disparities research at TUFCCC and HC by providing expert experimental design, bioinformatics, data management, genomics and data analysis support to TUFCCC/HC Cancer Partnership scientists. Members of the core have substantial knowledge and experience in biostatistics, bioinformatics, genomics and epidemiology as applied to cancer research. This highly interactive group of biostatisticians, bioinformatics, informaticians, geneticists and epidemiologists will serve all Partnership projects, pilot studies and cores and support future projects and pilot studies. The specific aims of the Biostatistics and Biostatistics Core are to: (1) Provide expert consultation for TUFCCC/HC Cancer Partnership investigators in the rigorous design of experiments and studies, including research proposal development, sample size determination, randomization procedures, experimental methods and plans for interim reviews and final analysis. (2) Perform statistical and bioinformatics analyses for TUFCCC/HC Cancer Partnership investigators using appropriate statistical and computing methodologies, as well as assist investigators with the writing of statistical and bioinformatics components of manuscripts and the interpretation and presentation of results. (3) Provide Informatics tools to enhance TUFCCC/HC Cancer Partnership research. Build cancer research capacity at HC by providing HC researchers with information systems that facilitate data entry, storage and retrieval. (4) Provide cost-effective, high-quality genomic and epigenetic services and expertise for the TUFCCC/HC Cancer Partnership including NextGen sequencing (e.g., DNA-Seq, RNA-Seq) as well cytogenetic analysis, chromosome and expression microarray solutions as needed. (5) Enable TUFCCC/HC investigators who may be non-technical users to easily access and manage large-scale genomic datasets and run bioinformatics data pipelines, through a user- friendly, web-browser accessible interface. By providing quantitative and genomics expertise and resources to investigators, and sharing technical capabilities, the BBC team will support the entire TUFCCC/HC Cancer Partnership and facilitate achievement of project aims and exploratory analyses beyond those stated.