Biostatistics and Bioinformatics Core (BBC)

项目摘要 生物统计学和生物信息学核心(共享资源) 联合领导：埃里克·A·罗斯博士(联席领导)HC：Konstantinos Krampis博士(联合领导) 生物统计和生物信息学核心(BBC)的目标是加强对癌症健康差异的研究 费城、新泽西和纽约市的非洲裔、亚裔和拉丁裔美国人社区服务不足 通过提供实验设计、生物统计学、生物信息学、基因组学、临床癌症遗传学、 混合方法研究、机器学习和人工智能。BBC成员的选择是基于 他们在定量科学、定性研究、高性能计算和软件方面拥有丰富的专业知识 开发、实验室研究和临床癌症遗传学。它的成员提供了创造 创新的方法和系统来解决快速变化中出现的新问题和新技术 科学环境。BBC的活动将利用在当前 资金周期，以加快未来，高质量的癌症差异研究在整个TUfcc/HC癌症 伙伴关系。这种高度互动的核心将在研究设计/执行的所有阶段发挥基础作用，以及所有 合作项目和核心将与BBC互动。生物统计学和生物统计学的具体目标 核心是：(1)在严谨的实验和研究设计中提供专家咨询，包括研究 建议书的开发。(2)通过对研究结果的适当分析，支持U54支持的研究 定量、混合方法和计算方法，内部开发的或当前在 菲尔德。协助调查人员解释和列报结果，并撰写统计和 手稿的生物信息学组成部分。(3)发展新型机器学习/人工智能(ML/AI) 通过增强从多组数据中提取知识来促进癌症差异研究的算法 资源。为癌症应用提供最新ML/AI研究工具方面的培训。(4)提供专家临床服务 癌症遗传学咨询，以及经济高效、高通量的基因组和表观遗传学服务，以满足关键 分子实验室所需的拟议研究项目以及未来由U54支持的研究。 维护用于收集、存储和分析U54产生的数据的计算基础设施- 支持调查。通过提供不同的专业知识、信息学和实验室工具，BBC将 支持该伙伴关系的使命，即在未得到充分服务和代表不足的人群中促进癌症公平 种族/少数族裔人口，同时打破代表少数族裔(URM)不足的系统性障碍 通过研究培训、支持和基础设施帮助实现 城市轨道交通调查员和实习生的职业生涯。

Project Summary Biostatistics and Bioinformatics Core (Shared Resource) TUFCCC: Eric A. Ross, PhD (Co-Leader) HC: Konstantinos Krampis, PhD (Co-Leader) The goal of the Biostatistics and Bioinformatics Core (BBC) is to enhance cancer health disparities research in underserved African-, Asian- and Latinx American communities in Philadelphia, New Jersey and New York City by providing expertise in experimental design, biostatistics, bioinformatics, genomics, clinical cancer genetics, mixed methods research, machine learning and artificial intelligence. BBC members were selected based on their substantial expertise in quantitative science, qualitative research, high performance computing and software development, laboratory investigations and clinical cancer genetics. Its members provide the capacity to create innovative methods and systems to address new problems and technologies that surface in a rapidly changing scientific environment. BBC activities will leverage the collaborations and tools developed during the current funding cycle to accelerate future, high-quality cancer disparities research throughout the TUFCCC/HC Cancer Partnership. This highly interactive Core will play fundamental roles in all phases of study design/execution, and all Partnership projects and cores will interact with the BBC. The specific goals of the Biostatistics and Biostatistics Core are to: (1) Provide expert consultation in the rigorous design of experiments and studies, including research proposal development. (2) Support U54-supported research by analyzing study results with appropriate quantitative, mixed methods, and computing approaches developed in-house or current best practices in the field. Assist investigators with the interpretation and presentation of results, and the writing of statistical and bioinformatics components of manuscripts. (3) Develop novel Machine Learning/Artificial Intelligence (ML/AI) algorithms to facilitate cancer disparities research by enhancing knowledge extraction from multi-omic data resources. Provide training in the latest ML/AI research tools for cancer applications. (4) Provide expert clinical cancer genetics advice, and cost-effective, high-throughput genomic and epigenetic services to meet the critical molecular laboratory needs of the proposed research projects as well as future U54-supported investigations. Maintain the computational infrastructure for the collection, storage and analysis of data generated by U54- supported investigations. By providing diverse expertise, and informatics and laboratory tools, the BBC will support the Partnership’s mission of advancing cancer equity among underserved and underrepresented racial/ethnic minority populations, while breaking systemic barriers that under-represented minorities (URM) encounter in the research workforce through research training, support and infrastructure that helps enable the careers of URM investigators and trainees.