A CT-Based Multiparametric Imaging Biomarker for Assessment of Pediatric Interstitial Lung Disease
基于 CT 的多参数成像生物标志物,用于评估小儿间质性肺疾病
基本信息
- 批准号:10484592
- 负责人:
- 金额:$ 24.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-10 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdoptionAdultAffectAlgorithmsApplications GrantsCharacteristicsChildChildhoodClassificationClinicalClinical ResearchCollaborationsComputer softwareConsumptionData SetDatabasesDevelopmentDiagnosisDiffuseDiseaseDyspneaEarly DiagnosisEvaluationFundingGoalsGrantHypoxemiaImageImaging technologyIndustryInfantInterstitial Lung DiseasesInterventionInvestmentsLearningLifeLos AngelesLungLung diseasesMedical DeviceMedical ImagingMicrotomyModelingMorbidity - disease rateOutcomePatientsPatternPediatric HospitalsPediatric ResearchPediatricsPhasePhysiciansPopulationPrognosisProgressive DiseaseRadiology SpecialtyReaderResearchResearch PersonnelScanningSensitivity and SpecificitySeverity of illnessStandardizationStructureSurvivorsSystemSystems AnalysisTechnologyTeenagersTestingTextureTimeTrainingTranslatingValidationVisualX-Ray Computed Tomographyaccurate diagnosisbasecare outcomeschest computed tomographyclinical research sitecostdata repositorydeep learningdeep learning algorithmdeep learning modeldisorder controlimaging biomarkerimprovedlung basal segmentlung imagingmortalitymultiparametric imagingpatient stratificationresearch clinical testingrespiratorysafety netstandard of caretransfer learningtreatment response
项目摘要
PROJECT SUMMARY
Childhood (diffuse) interstitial lung diseases affects infants, children, and teens and
manifests as dyspnea, hypoxemia, and respiratory compromise resulting in high
morbidity and mortality or life-long sequelae for survivors. Despite improvements in the
understanding of and interventions for pediatric diffuse lung disease in the past 15
years, the current standard-of-care for confirmation and characterization of chILD by
thin-section chest computed tomography (CT) has had limited progress through visual
assessments that are inherently subjective and suffer from inter-reader variability in
defining the specific characteristic findings. This can limit accurate diagnosis of early
and progressive disease and translates to a more time-consuming and burdensome
clinical evaluation. An automated and objective approach to quantify common
radiological lung CT patterns observed in ILDs specifically in pediatrics would provide
more reliable information and reduce costs by standardizing and streamlining image-
based assessment.
In this grant proposal, Imbio Inc., an industry leader in developing, commercializing, and
achieving regulatory approval of imaging biomarker software, proposes to develop a
fully-automated software application for quantifying lung CT textures. The collaboration
leverages the clinical and research expertise at the Children’s Hospital Los Angeles
(CHLA) which is a large, safety-net pediatric hospital. The specific aims are 1) to
develop a data repository of chest CT scans in subjects with pediatric diffuse lung
disease and control subjects along with expert annotations of radiologic textures and 2)
develop and validate an integrated pediatric/adult deep-learning-based algorithm to
quantify radiological lung textures (i.e., DeepLTA). Upon completion of the aims, the
final algorithm will have broad applicability and generalizability to detect parenchymal
CT textures in both adult and pediatric ILDs. This will enable a Phase II submission and
integration of this software to enhance pediatric access to state-of-the-art quantitative
medical imaging analysis for improved prognosis, diagnosis, and therapy response
assessment in pediatric interstitial lung disease.
项目摘要
儿童(弥漫性)间质性肺病影响婴儿、儿童和青少年,
表现为呼吸困难、低氧血症和呼吸损害,导致高
发病率和死亡率或幸存者的终身后遗症。尽管在这方面有所改善,
过去15年对小儿弥漫性肺病的认识和干预
年,通过以下方法确认和表征儿童的现行护理标准
薄层胸部计算机断层扫描(CT)通过视觉的进展有限,
评估本身是主观的,并受到读者之间的差异,
定义特定的特征发现。这可能会限制早期诊断的准确性。
和进行性疾病,并转化为更耗时和负担
临床评价一种自动化和客观的方法来量化常见的
在ILD中观察到的放射学肺部CT模式,特别是在儿科中,
通过标准化和简化图像,获得更可靠的信息并降低成本-
基于评估。
在这项拨款提案中,英比奥公司,在开发、商业化和
实现成像生物标志物软件的监管批准,建议开发一个
用于量化肺部CT纹理的全自动软件应用程序。协作
利用洛杉矶儿童医院的临床和研究专长,
(CHLA)是一家大型的安全网儿科医院。具体目标是:(1)
开发儿科弥漫性肺受试者胸部CT扫描数据库
疾病和对照受试者沿着放射学纹理的专家注释,以及2)
开发并验证基于深度学习的集成儿科/成人算法,
量化放射性肺纹理(即,DeepLTA)。在完成目标后,
最终的算法将具有广泛的适用性和普适性,以检测实质
成人和儿童ILD的CT纹理。这将使第二阶段提交和
集成该软件以增强儿科获得最先进的定量分析的能力
用于改善预后、诊断和治疗反应的医学成像分析
评估小儿间质性肺疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Kai David Ludwig其他文献
Kai David Ludwig的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Standard Grant
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 24.9万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 24.9万 - 项目类别:
Grant-in-Aid for Scientific Research (C)