Enhancement to Leak Free Non-Invasive Ventilation Mask for Infectious Patients

项目总结/摘要 大量患有COVID-19和SARS等传染性呼吸道疾病的患者需要呼吸道护理。 支持.通过面罩进行无创正压通气（NPPV）是许多患者的适当治疗方法。 可以比插管带来更好的结果。此外，用于NPPV的设备（如 CPAP机器）广泛使用，使NPPV非常适合应对疫情和流行病。 不幸的是，NPPV口罩通过传播受污染的气溶胶增加了疾病传播的风险 从面罩密封处泄漏。这使卫生保健工作者和其他患者面临更大的风险， 阻碍控制传染病爆发的努力。该计划的目标是开发一个 创新的NPPV患者接口，消除了污染的气溶胶通过面罩密封泄漏。 我们建议加强Creare的新型无泄漏面罩技术，使其更容易使用，更实用 在重症监护室里我们的设备将具有成本效益，并很容易与现有的CPAP机器广泛集成 在医院使用。这将使NPPV疗法在保护健康的同时广泛用于感染性患者 护理人员和其他病人。这项技术将成为治疗患者的关键工具，同时防止 传染性呼吸道疾病在医院环境中的传播。在第一阶段，我们将展示 我们通过建立和测试实验室原型来增强技术的可行性。

PROJECT SUMMARY/ABSTRACT A large number of patients with infectious respiratory diseases such as COVID-19 and SARS require respiratory support. Noninvasive Positive Pressure Ventilation (NPPV) via a mask is an appropriate treatment for many patients that can lead to better outcomes than intubation. Additionally, the equipment used for NPPV (such as CPAP machines) is widely available, making NPPV well suited for responding to outbreaks and pandemics. Unfortunately, NPPV masks increase the risk of disease transmission by spreading contaminated aerosols leaking from the mask seal. This exposes health care workers and other patients to increased risk and can hamper efforts to contain outbreaks of infectious diseases. The objective of this program is to develop an innovative NPPV patient interface that eliminates the leakage of contaminated aerosols through the mask seal. We propose to enhance Creare's novel leak-free mask technology to make it easier and more practical to use in a critical care setting. Our device will be cost effective and integrate easily with existing CPAP machines widely used in hospitals. This will enable widespread use of NPPV therapy on infectious patients while protecting health care workers and other patients. This technology will be a critical tool for treating patients while preventing the spreading of infectious respiratory diseases in a hospital setting. In the Phase I program, we will demonstrate the viability of our enhanced technology through building and testing laboratory prototypes.