Developing research training in Zambia to address the epidemic of cardiovascular disease and mental illness amongst HIV infected populations.

在赞比亚开展研究培训，以解决艾滋病毒感染人群中心血管疾病和精神疾病的流行问题。

• 批准号: 10482380
• 负责人: Carolyn Bolton
• 金额: $ 3.05万
• 依托单位: CENTRE FOR INFECTIOUS DISEASE RESEARCH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10482380
• 关键词: Address; Aging; COVID-19 outbreak; Cardiovascular Diseases; Caring; Collaborations; Comprehensive Health Care; Congestive Heart Failure; Country; Data; Diabetes Mellitus; Enrollment; Epidemic; Funding; Goals; Grant; HIV; HIV-1; Health; Heart Diseases; Improve Access; Indigenous; Individual; Institution; Investments; Life Expectancy; Medical; Mental Health; Mental disorders; Morbidity - disease rate; Myocardial Infarction; Persons; Population; Prevalence; Principal Investigator; Research; Research Personnel; Research Training; Resource-limited setting; Risk Factors; SARS-CoV-2 infection; Services; Specificity; Training; Training Programs; Universities; Washington; Woman; Zambia; antiretroviral therapy; authority; care providers; comorbidity; dissemination strategy; hypertensive heart disease; implementation strategy; low and middle-income countries; men; mortality; treatment program

Project Summary/Abstract: The overarching goal of this D71 planning grant is to develop a D43 research-training program in cardiac disease and mental illness amongst HIV infected individuals enrolled in the National HIV Care and Treatment Program in Zambia. In 2018, 1.2 million people in Zambia were living with HIV1. In 2016, life expectancy for men was 60 years and for women 64 years, a considerable increase from 49.4 years in 2012, partly due to improved access to antiretroviral treatment (ART). 2 However, despite the considerable increase in life expectancy, mortality amongst the HIV infected population remains significant. Non-communicable diseases (NCDs), in particular cardio-vascular disease (incorporating hypertensive heart disease, myocardial infarction and congestive cardiac failure), aging and mental illness are increasingly responsible for high morbidity and mortality in low- and middle- income countries (LMICs) such as Zambia. CIDRZ, an indigenous research organization in Zambia, has been leading the efforts to establish and maintain high quality, comprehensive care for HIV infected individuals across the country. The significant investment into HIV services (including PEPFAR) have resulted in a cadre of well trained, skilled and confident HIV care providers and clinicians. However, the specificity of their training has meant that there is a dearth of trained researchers and investigators to identify the relevant research questions and also a shortage of competent and trained clinicians to deal with significant co- morbidities including diabetes, cardiovascular disease, aging and, of note, mental health issues. More recently, these gains are being eroded by the outbreak of SARS-CoV-2 infection whose impact on HIV-infected individuals particularly in our resource constrained setting remains unknown. CIDRZ, in collaboration with Washington University in St. Louis, proposes to partner with the University of Zambia, the University of Lusaka, Levy Mwanawasa Medical University, the Ministry of Health, and the National Health Research Authority to establish a training platform for ongoing high-quality HIV/ NCD research. We are requesting funding under this D71 to prepare for, and ultimately construct, a D43 that would aim to: 1. Increase the pool of qualified, competent researchers and principal investigators; 2. Increase and enhance locally-generated NCDs prevalence and risk factor data amongst HIV infected individuals; 3. develop dissemination and implementation strategies and 4. Develop collaborations with other research institutions and universities both locally and within the sub-region to leverage off current capacity and enhance the research capability.

项目摘要/摘要：这项D71规划拨款的首要目标是开发一个 D43艾滋病毒感染者的心脏病和精神疾病研究培训方案 在赞比亚参加国家艾滋病毒护理和治疗计划的个人。2018年， 赞比亚有120万人感染了HIV1。2016年，男性预期寿命为60岁。 女性为年，较2012年的49.4年大幅增加，部分原因是 改善获得抗逆转录病毒治疗的机会(抗逆转录病毒治疗)。然而，尽管有相当大的 尽管预期寿命增加了，但艾滋病毒感染者的死亡率仍然很高。 非传染性疾病，特别是心血管疾病(包括 高血压心脏病、心肌梗死和充血性心力衰竭)、衰老和 精神疾病日益成为中低收入人群高发病率和高死亡率的原因。 收入国家(LMIC)，如赞比亚。CIDRZ，一个本土的研究组织 赞比亚一直在带头努力建立和保持高质量、全面 关爱全国范围内的艾滋病毒感染者。对艾滋病毒的重大投资 服务(包括紧急救援)培养了一支训练有素、技术娴熟、自信满满的干部队伍 艾滋病毒护理提供者和临床医生。然而，他们训练的特殊性意味着 缺乏训练有素的研究人员和调查人员来确定相关研究 问题，以及缺乏有能力和训练有素的临床医生来处理重大的联合 疾病包括糖尿病、心血管疾病、老龄化以及值得注意的精神健康 问题。最近，这些成果正在被SARS-CoV-2感染的爆发所侵蚀 它对艾滋病毒感染者的影响，特别是在我们资源有限的情况下 仍然不为人知。CIDRZ与圣路易斯华盛顿大学合作，提出 与赞比亚大学、卢萨卡大学、利维·姆瓦纳瓦萨医学院合作 大学、卫生部和国家卫生研究局建立一个 正在进行的高质量艾滋病毒/非传染性疾病研究的培训平台。我们正在申请拨款。 此D71用于准备并最终构建D43，其目标是：1.增加池 合格、称职的研究人员和首席调查人员；2.增加和加强 艾滋病毒感染者中本地产生的非传染性疾病流行率和危险因素数据； 制定传播和实施战略；4.发展与其他人的合作 当地和次区域内的研究机构和大学利用 现有能力，增强研究能力。