RapiPath follow-on: Rapid mastitis testing through automated protocols

RapiPath 后续产品：通过自动化方案进行快速乳腺炎检测

• 批准号: 10094384
• 金额: $ 28.77万
• 依托单位: RAFT SOLUTIONS LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10094384
• 关键词: RapiPath; follow; Rapid; mastitis; testing

Clinical mastitis is one of the major causes for antimicrobial use on dairy cattle farms. There is evidence to demonstrate that on-farm tests help motivate and engage farm staff with the control of mastitis, but continuous monitoring of farm protocols and procedures is required by the herd's vet. There are now many options for on-farm mastitis diagnostics available, helping to decide which antimicrobial to use. However, the mastitis treatment protocols integrating on-farm diagnostics are rapidly changing with some data now available to demonstrate that gram-negative infections are likely to result in self-cure. Therefore, appropriate quality assurance should be considered for a successful on-farm diagnostic test.The use of diagnostics is widely recognised as a powerful tool for improving animal health, with a wide variety of diagnostic tests available using a variety of biochemical and physical techniques. However, a common challenge to most diagnostics tools used in agriculture/veterinary medicine is a lack system integration and a slow pace of diagnosis. As a result, massive inefficiencies in logistics, increased wastage, and a lack of evidence for key policy making, especially for the dairy industry exist.In this project, the consortium will build upon work completed in IUK project 105144 for the rapid target identification of mastitis pathogens capable of identifying 16 different pathogens, facilitating specific diagnosis. Delivering fast (~1hr), low-cost testing whilst maintaining excellent sensitivity/specificity. A specific innovation focuses on the combination species panel of target microorganisms included in the diagnostic, enabling the discrimination of contaminated samples and identifies the pathogens present in each sample, informing treatment decisions.By developing a novel hardware and software solution to collate and share diagnostic results, it is hoped that animal health and welfare will be improved and protected, farm productivity maximised through disease reduction and logistical barriers relating to expression of expected milk yield can be overcome.

临床乳腺炎是奶牛场抗菌剂使用的主要原因之一。有证据表明，农场测试有助于激励和吸引农场工作人员控制乳腺炎，但是群兽医需要对农场协议和程序进行持续监测。现在有很多可用于农场乳腺炎诊断的选择，有助于决定使用哪种抗菌剂。然而，整合农场诊断的乳腺炎治疗方案正在迅速与一些数据一起改变，以证明革兰氏阴性感染可能会导致自我治疗。因此，对于成功的农场诊断测试，应考虑适当的质量保证。诊断的使用被广泛认为是改善动物健康的有力工具，并使用多种生化和物理技术可用多种诊断测试。但是，对农业/兽医医学中使用的大多数诊断工具的普遍挑战是缺乏系统整合和诊断的缓慢。结果，物流中的大量效率低下，浪费增加以及缺乏关键政策制定的证据，尤其是对乳制品行业的存在。快速提供（〜1小时），低成本测试，同时保持出色的灵敏度/特异性。特定的创新侧重于诊断中包含的目标微生物组合小组组合，从而判断受污染的样品的区分，并确定每个样本中存在的病原体，从而为治疗决策提供信息。通过开发一种新颖的硬件和软件解决方案，以改善和分享诊断，并希望将动物健康和福利造成疾病，以使动物健康和诊断的形式发展，可以使动物健康的生产力促进效果，从而实现型号的作品，使其成熟效果，造型性效果效率，使得动物健康效率效果。可以克服预期的牛奶产量。