Behavioral Core B

项目总结 芝加哥肌肉骨骼疼痛中心(C-COMP)的首要目标是促进和支持 旨在了解肌肉骨骼疼痛(MSK)潜在机制的研究和培训 疾病，其最终目标是更好地管理和预防疾病。对疾病特异性疼痛的评估- 合适的风湿性和MSK临床前模型的相关行为和其他躯体感觉变化 疾病是研究与这些疾病相关的潜在疼痛机制的基石之一。 疾病，对于开发MSK疼痛的新疗法是必要的。行为核心B将 通过提供独特的资源、世界级的专业知识和有效的培训来支持这一目标 MSK和风湿病动物模型的行为学变化。我们将利用我们的联合 在骨关节炎和其他MSK疾病模型方面的专业知识，我们将聘请世界级的啮齿动物专家 为疼痛行为提供持续指导。这种方法将支持急需的高质量研究。 并将促进更广泛地使用适当的行为措施，如 MSK病的临床前研究结果。这样的服务是探索机制的先决条件 与MSK疾病相关的潜在疼痛，以及增加动物模型的翻译实用性。 最终，我们预计，在正确的模式中选择正确的行为将有助于小说的发展， 安全有效的镇痛剂。核心B中提供的行为分析已被选择为与 神经生物学核心C，这将进一步实现对疼痛路径的机械性评估。我们自己加在一起 在行为领域积累的经验、确立的创新和国际领先地位 MSK疾病啮齿动物模型的特征为我们提供了独特的资格来建议和 支持研究人员评估MSK模型中行为变化的最有效策略。这个 CORE将通过以下目标实现其目标：目标1.建立集中资源，以 促进MSK疾病模型中的行为分析。我们将提供完整的行为分析小组， 涵盖所有类型的体感变化。中心将提供动物行为方面的实践培训 测试、定制协议、设备和测试空间。目标2.提供咨询服务，并提供 定制的全方位服务选项，用于将行为测试应用于关节炎和MSK的临床前模型 疾病。该核心将为研究设计提供科学指导，并就如何 将行为测试应用于MSK模型。核心将提供技术专业知识，以定制、全面 服务行为测试选项提供给实验室，包括芝加哥以外的实验室。目标3.培训 在评估关节炎和其他MSK疾病模型的行为变化方面，研究社区。 我们将提供现场和虚拟培训，举办研讨会和开发教育材料，以 增强中心调查人员对如何将行为测试整合到他们的实验室中的理解。

Project summary The overarching goal of the Chicago Center on Musculoskeletal Pain (C-COMP) is to foster and support research and training aimed at understanding the mechanisms underlying pain in musculoskeletal (MSK) disease, with the ultimate goal of better managing and preventing it. Assessment of disease-specific pain- related behaviors and other somatosensory changes in appropriate preclinical models of rheumatic and MSK diseases is one of the cornerstones for the study of mechanisms underlying pain associated with these diseases, necessary for the development of new therapeutics for MSK pain. The Behavioral Core B will support this goal by providing unique resources, world class expertise, and effective training to assess behavioral changes in animal models of MSK and rheumatic diseases. We will capitalize on our combined expertise in models of osteoarthritis and other MSK diseases, and we will engage world class experts in rodent pain behaviors to provide continued guidance. This approach will support much needed high-quality research and training in this field and will facilitate a more wide-spread use of appropriate behavioral measures as outcomes in preclinical studies of MSK disease. Such a service is a prerequisite for exploring mechanisms underlying pain associated with MSK diseases, and for increasing the translational utility of animal models. Ultimately, we expect that choosing the right behaviors in the right models will aid the development of novel, safe, and efficacious analgesics. The behavioral assays offered in Core B have been chosen to synergize with Neurobiology Core C, which will further enable mechanistic evaluation of pain pathways. Our own combined cumulative experience and established innovation and international leadership in the behavioral characterization of rodent models of MSK diseases provides us with unique qualifications to advise and support researchers about the most efficient strategies to evaluate behavioral changes in MSK models. The Core will achieve its objectives through the following aims: Aim 1. Establish a centralized resource to facilitate behavioral assays in MSK disease models. We will provide a full panel of behavioral assays that cover all types of somatosensory changes. The Core will provide hands-on training in animal behavioral testing, customized protocols, equipment, and testing space. Aim 2. Provide a consultation service, and a customized, full-service option for applying behavioral testing to preclinical models of arthritis and MSK disease. The Core will provide scientific guidance for the design of studies and consulting services on how to apply behavioral testing to MSK models. The Core will provide technical expertise to make customized, full- service behavioral testing options available to laboratories, including labs outside of Chicago. Aim 3. Train the research community in evaluating behavioral changes in models of arthritis and other MSK diseases. We will provide both in person and virtual training, present seminars and develop educational material to enhance Center investigators’ understanding of how to integrate behavioral testing into their laboratories.