Behavioral Core B

项目摘要 芝加哥肌肉骨骼疼痛中心（C-COMP）的首要目标是促进和支持 研究和培训，旨在了解肌肉骨骼疼痛（MSK）的潜在机制 疾病，最终目标是更好地管理和预防它。评估疾病特异性疼痛- 在适当的风湿性和MSK临床前模型中的相关行为和其他躯体感觉变化 疾病是研究与这些疾病相关的疼痛机制的基石之一。 这些疾病是开发MSK疼痛新疗法所必需的。行为核心B将 通过提供独特的资源、世界一流的专业知识和有效的培训来支持这一目标， MSK和风湿性疾病动物模型的行为变化。我们将利用我们的联合优势 专业知识的模型骨关节炎和其他MSK疾病，我们将聘请世界一流的专家在啮齿动物 疼痛行为提供持续的指导。这种方法将支持急需的高质量研究 和培训，并将促进更广泛地使用适当的行为措施， MSK疾病临床前研究的结果。这样的服务是探索机制的前提 与MSK疾病相关的潜在疼痛，以及增加动物模型的转化效用。 最终，我们希望在正确的模型中选择正确的行为将有助于开发新的， 安全有效的止痛药。核心B中提供的行为测定已被选择用于协同 神经生物学核心C，这将进一步实现疼痛通路的机械评价。我们自己的加起来 积累的经验和建立的创新和国际领先的行为 MSK疾病的啮齿动物模型的表征为我们提供了独特的资格， 支持研究人员关于最有效的策略来评估MSK模型中的行为变化。的 核心将通过以下目标实现其目标：目标1。建立集中资源， 促进MSK疾病模型中的行为测定。我们将提供一个完整的行为分析小组， 涵盖所有类型的躯体感觉变化。核心将提供动物行为方面的实践培训 测试、定制协议、设备和测试空间。目标二。提供咨询服务， 定制的全方位服务选项，用于将行为测试应用于关节炎和MSK的临床前模型 疾病该核心将为研究设计和咨询服务提供科学指导， 将行为测试应用于MSK模型。核心将提供技术专长，使定制的，完整的- 服务行为测试选项提供给实验室，包括芝加哥以外的实验室。目标3：训练 研究社区在评估关节炎和其他MSK疾病模型的行为变化。 我们将提供面对面和虚拟培训，举办研讨会，并开发教育材料， 提高中心研究人员对如何将行为测试整合到他们的实验室的理解。

Project summary The overarching goal of the Chicago Center on Musculoskeletal Pain (C-COMP) is to foster and support research and training aimed at understanding the mechanisms underlying pain in musculoskeletal (MSK) disease, with the ultimate goal of better managing and preventing it. Assessment of disease-specific pain- related behaviors and other somatosensory changes in appropriate preclinical models of rheumatic and MSK diseases is one of the cornerstones for the study of mechanisms underlying pain associated with these diseases, necessary for the development of new therapeutics for MSK pain. The Behavioral Core B will support this goal by providing unique resources, world class expertise, and effective training to assess behavioral changes in animal models of MSK and rheumatic diseases. We will capitalize on our combined expertise in models of osteoarthritis and other MSK diseases, and we will engage world class experts in rodent pain behaviors to provide continued guidance. This approach will support much needed high-quality research and training in this field and will facilitate a more wide-spread use of appropriate behavioral measures as outcomes in preclinical studies of MSK disease. Such a service is a prerequisite for exploring mechanisms underlying pain associated with MSK diseases, and for increasing the translational utility of animal models. Ultimately, we expect that choosing the right behaviors in the right models will aid the development of novel, safe, and efficacious analgesics. The behavioral assays offered in Core B have been chosen to synergize with Neurobiology Core C, which will further enable mechanistic evaluation of pain pathways. Our own combined cumulative experience and established innovation and international leadership in the behavioral characterization of rodent models of MSK diseases provides us with unique qualifications to advise and support researchers about the most efficient strategies to evaluate behavioral changes in MSK models. The Core will achieve its objectives through the following aims: Aim 1. Establish a centralized resource to facilitate behavioral assays in MSK disease models. We will provide a full panel of behavioral assays that cover all types of somatosensory changes. The Core will provide hands-on training in animal behavioral testing, customized protocols, equipment, and testing space. Aim 2. Provide a consultation service, and a customized, full-service option for applying behavioral testing to preclinical models of arthritis and MSK disease. The Core will provide scientific guidance for the design of studies and consulting services on how to apply behavioral testing to MSK models. The Core will provide technical expertise to make customized, full- service behavioral testing options available to laboratories, including labs outside of Chicago. Aim 3. Train the research community in evaluating behavioral changes in models of arthritis and other MSK diseases. We will provide both in person and virtual training, present seminars and develop educational material to enhance Center investigators’ understanding of how to integrate behavioral testing into their laboratories.