Immune Regulation of Gastric Cancer

胃癌的免疫调节

• 批准号: 10487425
• 负责人: Jonathan Busada
• 金额: $ 26.91万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10487425
• 关键词: ATAC-seq; Adrenalectomy; Cancer Etiology; Cancer Patient; Centers of Research Excellence; Cessation of life; Chromatin; Coculture Techniques; Data; Development; Environment; Epigenetic Process; Epithelial; Foundations; Funding; Funding Mechanisms; Gastric Metaplasia; Gastric mucosa; Gastritis; Genes; Glucocorticoid Receptor; Glucocorticoids; Goals; Helicobacter Infections; Helicobacter pylori; Hyperactivity; Immune; Infection; Inflammation; Inflammatory; Knockout Mice; Macrophage Activation; Malignant Neoplasms; Messenger RNA; Modeling; Molecular; Myelogenous; Pathogenicity; Pathway interactions; Physiological; Population; Problem Solving; Role; Shapes; Signal Transduction; Stimulus; Stomach; Testing; Time; Uncertainty; cancer diagnosis; carcinogenesis; cytokine; epigenome; gastric organoids; immunoregulation; macrophage; malignant stomach neoplasm; mouse model; response; single-cell RNA sequencing; transcriptome; transcriptome sequencing; tumor; tumor microenvironment

Gastric cancer is the 3rd leading cause of cancer deaths worldwide. Over 90% of gastric cancers are associated with long-term Helicobacter pylori infection. However, the infection alone has limited pathogenic effects on the gastric mucosa. Rather, the infection triggers massive gastric inflammation, which becomes increasingly hyperactive, damaging the stomach and creating the requisite environment for carcinogenesis. However, the mechanisms and pathways that regulate the onset of hyperactive inflammation are unknown.

胃癌是全球癌症死亡的第三大原因。超过90%的胃癌与长期幽门螺杆菌感染有关。然而，单独感染对胃粘膜的致病作用有限。相反，这种感染会引发大量的胃部炎症，炎症会变得越来越活跃，损害胃，为癌变创造必要的环境。然而，调节过度活跃炎症发生的机制和途径尚不清楚。