Method Core

方法核心

基本信息

项目摘要

Musculoskeletal (MSK) injuries and diseases are the leading cause of disability across the lifespan. The pathophysiology of MSK disease is complex, and clinical research requires a broad range of data types including electronic health record (EHR) data (patient characteristics, treatments, and clinical outcomes), standardized physical performance measures, bone imaging, laboratory measures, omics data (e.g. genomics, proteomics, metabolomics), patient reported outcome tools, and social determinants of health. A lack of integration of these complex ‘big data’ sources impedes access and utilization by investigators. The goal of the Indiana Center for Musculoskeletal Health-Clinical Research Center is to provide access to state-of-the-art informatics resources and technology to define and characterize MSK biology and disease genotypes; computable, molecular, functional, and clinical phenotypes; and the social factors, collectively mediating MSK health, disease and disability across the lifespan, and to develop cures. In our initial P30 funding period, we established a Musculoskeletal Informatics Methodology (MIM) Core, leveraging a large inter-organizational integrated health information exchange of EHR data to detect several computable (assessed from the EHR) MSK phenotypes, that incorporate diagnosis and other codes, medications, laboratory values and/or clinical text notes. We integrated such computable phenotypes with the measurements (physical performance and bone assessments) and associated biospecimens from the ICMH-CRC FIT Core, to support investigators in clinical study design, feasibility assessments, and translating bench discoveries to humans. In the current proposal, the MIM Core will expand our support of investigators in multi-disciplinary clinical and translational research leveraging the use of novel informatics methods and resources, to improve musculoskeletal health. The MIM Core will develop a large facile, secure Musculoskeletal Data Mart that integrates and makes ready for clinical research, data from multiple resources including: 1) EHR systems of the Indiana Network for Patient Care, using computable phenotypes to generate a cohort of more than 880,000 patients with MSK disorders, 2) community data systems information on social determinants of health and other risk factors, and 3) the full data from the FIT Core musculoskeletal phenotyping, biospecimens, and genomic data. This Data Mart will facilitate feasibility analyses, grant support, and retrospective and prospective studies to support translational research from bench to bedside and back. The MIM Core will also provide statistical support for clinical trial design, and informatics and data science approaches such as applying natural language processing to extract EHR text data, health informatics analyses of outcomes, integrative genomic analyses, and applying machine learning models to predict clinical outcomes. These new and innovative initiatives will link the researchers of the Indiana Center for Musculoskeletal Health to state-of-the-art resources, advancing musculoskeletal science to ultimately benefit public and individual health and mobility.
肌肉骨骼(MSK)损伤和疾病是一生中致残的主要原因。的

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Erik Allen Imel其他文献

Erik Allen Imel的其他文献

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{{ truncateString('Erik Allen Imel', 18)}}的其他基金

Sarcopenia: computable phenotypes and clinical outcomes.
肌肉减少症:可计算的表型和临床结果。
  • 批准号:
    10378772
  • 财政年份:
    2020
  • 资助金额:
    $ 25.92万
  • 项目类别:
Method Core
方法核心
  • 批准号:
    10707147
  • 财政年份:
    2017
  • 资助金额:
    $ 25.92万
  • 项目类别:
FGF23 in Pediatric Phosphate Physiology and X-linked Hypophosphatemic Rickets.
FGF23 在小儿磷酸盐生理学和 X 连锁低磷血症性佝偻病中的作用。
  • 批准号:
    7786171
  • 财政年份:
    2009
  • 资助金额:
    $ 25.92万
  • 项目类别:
FGF23 in Pediatric Phosphate Physiology and X-linked Hypophosphatemic Rickets.
FGF23 在小儿磷酸盐生理学和 X 连锁低磷血症性佝偻病中的作用。
  • 批准号:
    7639753
  • 财政年份:
    2009
  • 资助金额:
    $ 25.92万
  • 项目类别:
FGF23 in Pediatric Phosphate Physiology and X-linked Hypophosphatemic Rickets.
FGF23 在小儿磷酸盐生理学和 X 连锁低磷血症性佝偻病中的作用。
  • 批准号:
    8101819
  • 财政年份:
    2009
  • 资助金额:
    $ 25.92万
  • 项目类别:
FGF23 in Pediatric Phosphate Physiology and X-linked Hypophosphatemic Rickets.
FGF23 在小儿磷酸盐生理学和 X 连锁低磷血症性佝偻病中的作用。
  • 批准号:
    8289355
  • 财政年份:
    2009
  • 资助金额:
    $ 25.92万
  • 项目类别:
FGF23 in Pediatric Phosphate Physiology and X-linked Hypophosphatemic Rickets.
FGF23 在小儿磷酸盐生理学和 X 连锁低磷血症性佝偻病中的作用。
  • 批准号:
    8502242
  • 财政年份:
    2009
  • 资助金额:
    $ 25.92万
  • 项目类别:

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职业:从动态算法到快速优化并返回
  • 批准号:
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合作研究:FuSe:基于硒化铟的后端神经形态加速器
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Relationships Between Pain-Related Psychological Factors, Gait Quality, and Attention in Chronic Low Back Pain
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