Administration and statistical/bioinformatics core

项目摘要 该计划项目补助金（PPG）建议探索衰老的重要，基本方面， 导致大脑功能在衰老过程中丧失。这种大脑功能的丧失，通常被称为 阿尔茨海默氏病（AD）和相关痴呆（ADRD）给人们带来了巨大的情感和经济负担 对美国和全世界的公民。核心A将组织和协调整个PPG， 对科学目标的成功至关重要。核心研究将由PPG主要研究者Judith领导 坎皮西和丽莎埃勒比。它将为项目规划小组提供基本职能，这些职能将通过以下方式执行： 七个相互关联的具体目标。这些目标包括促进 项目（项目1-3）和其他核心（核心B-D），组织项目和核心之间的定期会议 科学咨询委员会（SAB）的工作人员和成员，将对 PPG的科学和行政进展。核心A还将提供 支持和监督，负责与国家老龄化研究所（NIA）沟通，包括 提交进度报告和讨论任何新的或改变的科学方向。此外，核心A 将促进和组织SAB成员的培训和旅行，重要的是， PPG（学生，博士后研究员，关键支持人员）。最后，核心A将提供统一的高级 通过专门的硬件、软件和人员为整个PPG提供统计和生物信息支持 由巴克学院的教员大卫弗曼监督。通过这些目标和服务，核心A将提供 关键的中央行政和科学支持的PPG，这将优化其科学的成功， 目标。

PROJECT SUMMARY This program project grant (PPG) proposes to explore important, fundamental aspects of aging that can result in the loss of brain function that occurs during aging. This loss of brain function, often termed Alzheimer's disease (AD) and related dementias (ADRD), imposes enormous emotional and financial burdens on citizens of the United States, and worldwide. Core A will organize and coordinate the entire PPG, and will be crucial for the success of its scientific goals. The Core will be led by the PPG Principal Investigators Judith Campisi and Lisa Ellerby. It will provide essential functions to the PPG, which will be implemented through seven interlinked specific aims. These aims include facilitating communication and collaboration among the Projects (Projects 1-3) and other Cores (Cores B-D), organizing regular meetings among the Project and Core personnel and members of the Scientific Advisory Board (SAB), which will provide critical assessments of the scientific and administrative progress of the PPG. Core A will also provide budgetary and administrative support and oversight, be responsible for communicating with the National Institute on Aging (NIA), including submission of progress reports and discussions of any new or altered scientific directions. In addition, Core A will facilitate and organize training and travel for SAB members and, importantly, for junior participants in the PPG (students, postdoctoral fellows, critical support personnel). Finally, Core A will provide unified high-level statistical and bioinformatic support to the entire PPG through dedicated hardware, software and personnel overseen by Buck faculty member David Furman. Through these aims and services, Core A will provide critical central administrative and scientific support to the PPG, which will optimize the success of its scientific aims.