Administration and statistical/bioinformatics core

项目总结 该计划项目赠款(PPG)建议探索老龄化的重要、基本方面，这些方面可以 会导致在衰老过程中大脑功能的丧失。这种大脑功能的丧失，通常被称为 阿尔茨海默病(AD)和相关痴呆(ADRD)会给人带来巨大的情感和经济负担 针对美国和世界各地的公民。核心A将组织和协调整个PPG，并将 对其科学目标的成功至关重要。核心将由PPG首席调查员朱迪思领导 坎皮西和丽莎·埃勒比。它将为PPG提供基本职能，这将通过以下方式实施 七个相互关联的具体目标。这些目标包括促进 项目(项目1-3)和其他核心(核心B-D)，组织项目和核心之间的定期会议 科学咨询委员会(SAB)的人员和成员，该委员会将对 PPG的科学和管理进步。核心A还将提供预算和行政 支持和监督，负责与国家老龄研究所(NIA)的沟通，包括 提交任何新的或更改的科学方向的进展报告和讨论。此外，核心A 将促进和组织SAB成员的培训和旅行，更重要的是，为参加 PPG(学生、博士后研究员、关键支持人员)。最后，核心A将提供统一的高水平 通过专门的硬件、软件和人员为整个PPG提供统计和生物信息支持 由巴克教职员工大卫·福尔曼监督。通过这些目标和服务，Core A将提供 向PPG提供关键的中央行政和科学支持，这将优化其科学研究的成功 目标。

PROJECT SUMMARY This program project grant (PPG) proposes to explore important, fundamental aspects of aging that can result in the loss of brain function that occurs during aging. This loss of brain function, often termed Alzheimer's disease (AD) and related dementias (ADRD), imposes enormous emotional and financial burdens on citizens of the United States, and worldwide. Core A will organize and coordinate the entire PPG, and will be crucial for the success of its scientific goals. The Core will be led by the PPG Principal Investigators Judith Campisi and Lisa Ellerby. It will provide essential functions to the PPG, which will be implemented through seven interlinked specific aims. These aims include facilitating communication and collaboration among the Projects (Projects 1-3) and other Cores (Cores B-D), organizing regular meetings among the Project and Core personnel and members of the Scientific Advisory Board (SAB), which will provide critical assessments of the scientific and administrative progress of the PPG. Core A will also provide budgetary and administrative support and oversight, be responsible for communicating with the National Institute on Aging (NIA), including submission of progress reports and discussions of any new or altered scientific directions. In addition, Core A will facilitate and organize training and travel for SAB members and, importantly, for junior participants in the PPG (students, postdoctoral fellows, critical support personnel). Finally, Core A will provide unified high-level statistical and bioinformatic support to the entire PPG through dedicated hardware, software and personnel overseen by Buck faculty member David Furman. Through these aims and services, Core A will provide critical central administrative and scientific support to the PPG, which will optimize the success of its scientific aims.