UMN Udall Imaging Core

摘要 明尼苏达大学(UMN)Udall成像核心，由Noam Harel博士领导，总部设在该大学 明尼苏达州享誉国际的磁共振研究中心(CMRR)将收购State- 为项目和催化剂中的所有对象提供最先进的高分辨率磁共振成像。UMN Udall的总主题 中心是开发基于电路的深部脑刺激(DBS)治疗帕金森氏病(PD)的新型疗法。 作为所有三个拟议项目的基础，Catalyst项目并与 支持这一主题，成像核心的总体目标是使用高级成像功能直接 DBS手术的解剖靶点可视化以及提供精确的位置和方向 植入后靶区内的个别刺激电极接触。 成像核心将结合几种尖端的MRI技术，包括高分辨率T1/T2和 磁化率加权成像(SWI)。还将对脑白质进行弥散加权成像(DWI) 用于创建目标区域和相关网络的特定于患者的解剖模型的气管造影术。至 补充静态解剖连通性信息，我们将使用 基于电路的认知功能/非运动区的静息状态和基于任务的功能磁共振(FMRI)数据。 对于项目1、2和Catalyst，PD患者将在7T MRI系统上使用由 我们在CMRR的团队。此外，在将植入Medtronic Percept的PD患者的子集中 系统中，将在3T磁共振系统上收集DBS-fMRI刺激的功能图。对于项目3，非人类 灵长类动物(HAP)将在新安装的第一台10.5T磁共振扫描仪上进行扫描，这也是CMRR的。 对于每个PD患者和每个NHP，成像核心将在DBS之前获取高分辨率MRI数据 术后进行头颅CT扫描。图像将被融合以提供全面的解剖 DBS目标的模型以及每个目标内各个DBS联系人的准确位置。 成像核心将提供患者特定的解剖模型，术后DBS导联的精确定位， 和丘脑底核(STN)和苍白球内段(GPI)的分隔 功能子区域。这些图像将提供无与伦比的解剖特征 个人的。由成像核心Will开发的特定于对象的解剖和功能连接模型 提供对完成UMN Udall中心的每个项目至关重要的数据。

ABSTRACT The University of Minnesota (UMN) Udall Imaging Core, led by Noam Harel, Ph.D. and based at the University of Minnesota’s internationally renowned Center for Magnetic Resonance Research (CMRR), will acquire state- of-the-art, high-resolution MRI for all subjects in the Projects and Catalyst. The overall theme of the UMN Udall Center is to develop novel, circuit based deep brain stimulation (DBS) therapies for Parkinson’s disease (PD). As a foundation for all three proposed projects, the Catalyst project and in collaboration with the other cores in support of this theme, the overall goal of the Imaging Core is to use advanced imaging capabilities for direct visualization of anatomical targets for DBS surgery as well as provide the precise location and orientation of individual stimulating electrode contacts within the target post-implantation. The Imaging Core will combine several cutting-edge MRI techniques, including high resolution T1/T2s and susceptibility weighted images (SWI). Diffusion weighted imaging (DWI) will also be acquired for white-matter tractography to create patient-specific anatomical models of the target region and associated networks. To complement the static anatomical connectivity information, we will create functional connectivity maps using resting-state and task based functional MRI (fMRI) data of circuit-based cognitive function/non-motor regions. For Projects 1, 2 and the Catalyst, PD patients will be scanned on a 7 T MRI system using tools developed by our team at the CMRR. In addition, in a subset of PD patients that will be implanted with the Medtronic Percept system, functional maps of DBS-fMRI stimulation will be collected on a 3T MRI system. For Project 3, non-human primates (NHPs) will be scanned on the newly installed, first of its kind, 10.5 T MRI scanner, also at the CMRR. For each PD patient and each NHP, the Imaging Core will acquire high-resolution MRI data prior to DBS implantation and a head CT scan after surgery. Images will be fused to provide a comprehensive anatomical model of the DBS target and the precise location of individual DBS contacts within each target. The Imaging Core will provide patient-specific anatomical models, precise post-surgery DBS lead localization, and parcellation of the subthalamic nucleus (STN) and internal segment of the globus pallidus (GPi) to their functional sub-regions. These images will provide unparalleled anatomical characterization specific to each individual. Subject specific models of anatomical and functional connectivity developed by the Imaging Core will provide data that is vital for the completion of each project in the UMN Udall Center.