PLASTICITY OF CORTICAL ENSEMBLE CONNECTIVITY IN VISUAL LEARNING
PLASTICITY OF CORTICAL ENSEMBLE CONNECTIVITY IN VISUAL LEARNING
批准号:
10490276
负责人:
William Andrew Stoy
金额:
$6.98万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-09-16 至 2024-09-15
关键词:
AddressAlgorithmsAmblyopiaBehaviorBlindnessBrainCalciumCellsChronicDataDiscriminationDiseaseEconomicsElectrodesElectrophysiology (science)ExhibitsFinancial compensationHumanImageIn VitroIndividualInterventionLeadLearningLinkMapsMeasuresMethodologyModalityMotionMusNeuronsNeurophysiology - biologic functionOcular ProsthesisOpticsPatternPopulationPropertyProsthesisReproducibilityRewardsRoboticsSensoryStimulusStructureStructure-Activity RelationshipSynapsesSynaptic plasticityTechniquesTechnologyTestingTimeVisionVision DisordersVisualVisual CortexVisual PerceptionVisual system structureVocabularyWorkarea striataeffective therapyin vivoneocorticalnovel therapeuticsoptogeneticspatch clamppostsynapticpresynapticrelating to nervous systemresponsesensory inputspatiotemporaltooltwo-photonvision developmentvisual informationvisual learningvisual processvisual processingvisual stimulus
中文摘要
视觉是一种重要的感官形式,我们依靠它来浏览世界并了解我们的生活。
四周视觉系统障碍导致严重的人际交往障碍和经济困难。
不幸虽然在描述视觉的细胞基础方面已经取得了很大进展,
人们对处理视觉信息的大脑回路的连通性知之甚少,
我们知道这种连通性是如何随时间变化的。我建议利用尖端的机器人和
光学技术,以澄清神经元集合(细胞的共同活动组)是如何连接在
初级视觉皮层(V1),即产生视觉感知的新皮层区域。V1展览中的合奏
活动模式与可再现的空间和时间结构,定义功能词汇
大脑皮层微电路最近的研究表明,合奏的激活是必要的,
足够的视觉感知。赫布假说认为,神经元反复
随着时间的推移,共同活动(合奏)可能比彼此更强烈的突触连接。
到群体之外的神经元。我将开发一个高通量的工具来测试这个赫布假说
使用机器人电生理学和全息技术,
光遗传学刺激(Aim 1)。然后,我将描述皮层的功能和结构变化,
用慢性双光子钙离子成像研究小鼠视觉学习过程中的微电路
视觉皮质,与突触可塑性和学习的赫布假说有关(目的2)。成功
完成目前的项目将建立一个整体活动和活动之间的结构联系,
大脑在视觉学习过程中,产生对视觉更完整的理解的进展
这是解决失明有效治疗方案缺乏问题的先决条件。
英文摘要
Vision is a critical sensory modality that we depend on to navigate through the world and understand our
surroundings. Disorders of the visual system lead to severe interpersonal deficits and to economic
immiseration. Although much progress has been made describing the cellular basis of visual perception,
little is known about the connectivity of brain circuits that process visual information, and even less is
known about how this connectivity changes over time. I propose to leverage cutting-edge robotic and
optical technologies to clarify how neuronal ensembles (coactive groups of cells) are connected in the
primary visual cortex (V1), the neocortical region where visual perception arises. Ensembles in V1 exhibit
activity patterns with reproducible spatial and temporal structures which define the functional vocabulary
of cortical microcircuits. It has been recently shown that the activation of ensembles is necessary and
sufficient for visual perception. The Hebbian hypothesis suggests that neurons that are repeatedly
coactive over time (ensembles) are likely to be more strongly synaptically connected to one another than
to neurons outside of the ensemble. I will develop a high-throughput tool to test this Hebbian hypothesis
of preferential synaptic connectivity within ensembles using robotic electrophysiology and holographic
optogenetic stimulation (Aim 1). I will then describe the functional and structural changes of cortical
microcircuits during visual learning using chronic two-photon calcium imaging of neurons in the mouse
visual cortex, in relation to the Hebbian hypothesis of synaptic plasticity and learning (Aim 2). Successful
completion the current project will establish a structural link between ensemble activity and the activity of
the brain during visual learning, yielding inroads towards a more complete understanding of visual
processing, a prerequisite to addressing the dearth of effective treatment options for blindness.
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PLASTICITY OF CORTICAL ENSEMBLE CONNECTIVITY IN VISUAL LEARNING
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批准号:10313069
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项目类别:
-
资助金额:$6.64万
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财政年份:2021
-
负责人:William Andrew Stoy
-
依托单位:
PLASTICITY OF CORTICAL ENSEMBLE CONNECTIVITY IN VISUAL LEARNING
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批准号:10693279
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项目类别:
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资助金额:$7.38万
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财政年份:2021
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负责人:William Andrew Stoy
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依托单位:
海外基金