Biopsychosocial Mechanisms in the Development and Progression of Periodontal Disease

牙周病发生和进展的生物心理社会机制

基本信息

  • 批准号:
    10489819
  • 负责人:
  • 金额:
    $ 2.71万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-01 至 2022-06-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY In recognition of the importance of treating whole persons, biopsychosocial approaches have long been championed. The emphasis in health and disease research, however, is in biological abnormalities. Examining diseases from psychological and socio-behavioral perspectives adds unique perspectives in understanding the etiology and course of any given disease. That is, greater understanding is needed in elucidating how and why biopsychosocial factors may precipitate the onset of disease. Periodontal disease continues to be among the most prevalent dental, oral, and craniofacial conditions across the globe. Patients with periodontal disease— especially those from underserved populations—are faced with potentially life-long symptoms that affect their overall health and quality of life. Additional work is needed to characterize the mechanisms that explain biopsychosocial relations contributing to periodontal disease. Thus, work that tackles the multidisciplinary and complex systems nature of periodontal disease is needed to help facilitate future preventative, mitigating, and restorative interventions based on biological, psychological, and socioeconomic mechanisms. During the F99 phase of this proposal, the awardee will continue through dissertation work, to examine a novel psycho- biological mechanism by exploring the role of the protein zonulin (modulator of tissue permeability) in periodontal parameters and its potential ability to explain the relation between psychological stress and periodontal disease. More specifically, the awardee will examine the relation of zonulin, as measured by serum, salivary, and gingival crevicular fluid ELISA, and periodontal disease parameters. Additionally, zonulin will be examined as a potential mediating and moderating factor in the relation between psychological stress and cytokines in periodontal examination participants. It is hypothesized that serum zonulin levels will mediate the relation between reports of psychological stress and various periodontal and inflammatory parameters (e.g., probing depth, attachment loss, IL-6 levels). In the K00 phase, the awardee will work in understanding the upstream socioeconomic (e.g., social networks) and psychological aspects (e.g., stress) of a biopsychosocial approach to understanding periodontal disease. It is hypothesized that people who report social connections with those they perceive to have poor oral health, who engage in risk behaviors (e.g. smoking, sugary diet), and who utilize dental care infrequently, will be more likely to report indicators of periodontal disease. Secondly, it is expected that poor psychological functioning will diminish social network effects. The F99 and K00 phases will utilize the training and mentorship gained as a predoctoral trainee and continuing to surround himself with mentors and in a multidisciplinary environment in his transition to the postdoctoral and early career stages of becoming an independent scholar. Thus, this award will facilitate the ability to identify novel biopsychosocial mechanisms in the development and progression of a complex oral disease through both its research and training plans.
项目摘要 由于认识到治疗整个人的重要性,生物心理社会方法长期以来一直是 冠军。然而,健康和疾病研究的重点是生物异常。检查 从心理和社会行为的角度来看疾病,增加了理解的独特视角, 病因学和任何给定疾病的过程。也就是说,在阐明如何和为什么需要更大的理解 生物、心理和社会因素可能促使疾病的发生。牙周病仍然是 地球仪上最普遍的牙齿、口腔和颅面疾病。牙周病患者- 特别是那些来自服务不足人群的人,面临着潜在的终身症状, 整体健康和生活质量。需要更多的工作来描述解释这些机制的特征。 牙周病的病因有哪些?因此,处理多学科和 需要牙周病的复杂系统性质,以帮助促进未来的预防,减轻, 基于生物、心理和社会经济机制的恢复性干预。在F99 在这一建议的阶段,获奖者将继续通过论文工作,研究一个新的心理, 通过探索蛋白质zonulin(组织通透性调节剂)在 牙周参数及其解释心理应激与牙周病关系的潜在能力 牙周病更具体地说,获奖者将研究zonulin的关系,如测量 血清、唾液和龈沟液ELISA和牙周病参数。此外,zonulin 将作为一个潜在的中介和调节因素之间的关系,心理压力 牙周检查参与者中的细胞因子。假设血清zonulin水平将介导 心理应激与牙周炎性参数关系 (e.g.,探测深度、附着丧失、IL-6水平)。在K 00阶段,获奖者将努力了解 上游社会经济(例如,社交网络)和心理方面(例如,应力) 牙周病的治疗方法据推测,那些报告 与那些他们认为口腔健康状况不佳的人的社会联系,他们从事危险行为(例如, 吸烟,含糖饮食),以及不经常使用牙科护理的人,将更有可能报告 牙周病其次,预计不良的心理功能将削弱社交网络 方面的影响. F99和K 00阶段将利用作为博士前实习生获得的培训和指导, 继续围绕自己与导师和在一个多学科的环境中,在他的过渡到 博士后和职业生涯的早期阶段,成为一个独立的学者。这一奖项将有助于 在复杂的口腔疾病的发展和进展中识别新的生物心理社会机制的能力 通过其研究和培训计划。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Food insecurity and consumption of cariogenic foods in mothers and their two-year-old children in Appalachia.
阿巴拉契亚地区母亲及其两岁儿童的粮食不安全和致龋食品的消费。
  • DOI:
    10.1111/jphd.12559
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    2.3
  • 作者:
    Bhaumik,Deesha;Wright,CaseyD;Marshall,TeresaA;Neiswanger,Katherine;McNeil,DanielW;Jones,AndrewD;Shaffer,JohnR;Marazita,MaryL;Foxman,Betsy
  • 通讯作者:
    Foxman,Betsy
Gastrointestinal distress as a potential mediator between stress and periodontal inflammation.
胃肠道不适是压力和牙周炎症之间的潜在中介。
  • DOI:
    10.1111/cdoe.12889
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    2.3
  • 作者:
    Wright,CaseyD;Heaton,Brenda;Garcia,RaulI;Leonard,MaureenM;Fasano,Alessio;McNeil,DanielW
  • 通讯作者:
    McNeil,DanielW
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Casey D Wright其他文献

Casey D Wright的其他文献

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{{ truncateString('Casey D Wright', 18)}}的其他基金

Biopsychosocial Mechanisms in the Development and Progression of Periodontal Disease
牙周病发生和进展的生物心理社会机制
  • 批准号:
    10156101
  • 财政年份:
    2021
  • 资助金额:
    $ 2.71万
  • 项目类别:
Biopsychosocial Mechanisms in the Development and Progression of Periodontal Disease
牙周病发生和进展的生物心理社会机制
  • 批准号:
    10414737
  • 财政年份:
    2021
  • 资助金额:
    $ 2.71万
  • 项目类别:
MEMBRANE IMPERMEABLE ALPHA1-ADRENERGIC RECEPTOR
膜不可渗透的 α1 肾上腺素受体
  • 批准号:
    8360555
  • 财政年份:
    2011
  • 资助金额:
    $ 2.71万
  • 项目类别:
Nuclear alpha1-Adrenergic Receptor Signaling in Adult Mouse Cardiace Myocytes
成年小鼠心肌细胞核 α1 肾上腺素能受体信号转导
  • 批准号:
    7545980
  • 财政年份:
    2009
  • 资助金额:
    $ 2.71万
  • 项目类别:
Nuclear alpha1-Adrenergic Receptor Signaling in Adult Mouse Cardiace Myocytes
成年小鼠心肌细胞核 α1 肾上腺素能受体信号转导
  • 批准号:
    8012838
  • 财政年份:
    2009
  • 资助金额:
    $ 2.71万
  • 项目类别:
Nuclear alpha1-Adrenergic Receptor Signaling in Adult Mouse Cardiace Myocytes
成年小鼠心肌细胞核 α1 肾上腺素能受体信号转导
  • 批准号:
    7688524
  • 财政年份:
    2009
  • 资助金额:
    $ 2.71万
  • 项目类别:

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激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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