Biopsychosocial Mechanisms in the Development and Progression of Periodontal Disease

牙周病发生和进展的生物心理社会机制

• 批准号: 10489819
• 负责人: Casey D Wright
• 金额: $ 2.71万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10489819
• 关键词: Adult; Affect; Age; Attitude; Award; Bacteria; Behavioral; Biological; Biological Factors; Biological Models; Clinical; Complex; Data; Dental; Dental Care; Dentistry; Development; Diagnostic; Diet; Disease; Environment; Enzyme-Linked Immunosorbent Assay; Etiology; Focal Infection; Frequencies; Future; Genetic Predisposition to Disease; Gingiva; Gingival Crevicular Fluid; Goals; Gram-Negative Bacteria; Health; Health behavior; Healthcare; Human; Immune response; Immunology; Individual; Inflammatory; Inflammatory Response; Interleukin-6; Intervention; Lead; Life; Maintenance; Measures; Mediating; Mentors; Mentorship; Modeling; Mouth Diseases; Mucous Membrane; Nature; Onset of illness; Oral; Oral health; Participant; Pathway Analysis; Patient Self-Report; Patients; Periodontal Diseases; Periodontic specialty; Periodontium; Permeability; Personal Satisfaction; Persons; Phase; Physiological; Population; Population Distributions; Porphyromonas gingivalis; Postdoctoral Fellow; Process; Proteins; Psychological Factors; Psychological Stress; Psychology; Quality of life; Reporting; Research; Research Training; Risk Behaviors; Risk Factors; Role; Salivary; Science; Scientist; Serum; Smoking; Social Behavior; Social Environment; Social Network; Socioeconomic Factors; Socioeconomic Status; Stress; Symptoms; System; Time; Tissues; Training; Translating; Underserved Population; Work; base; biopsychosocial; biopsychosocial factor; career; craniofacial; cytokine; disorder prevention; disorder risk; experience; improved; multidisciplinary; novel; novel marker; person centered; pre-doctoral; psychobiologic; psychologic; psychosocial; response; scaling and root planing; social; social culture; social epidemiology; socioeconomics; zonulin

PROJECT SUMMARY In recognition of the importance of treating whole persons, biopsychosocial approaches have long been championed. The emphasis in health and disease research, however, is in biological abnormalities. Examining diseases from psychological and socio-behavioral perspectives adds unique perspectives in understanding the etiology and course of any given disease. That is, greater understanding is needed in elucidating how and why biopsychosocial factors may precipitate the onset of disease. Periodontal disease continues to be among the most prevalent dental, oral, and craniofacial conditions across the globe. Patients with periodontal disease— especially those from underserved populations—are faced with potentially life-long symptoms that affect their overall health and quality of life. Additional work is needed to characterize the mechanisms that explain biopsychosocial relations contributing to periodontal disease. Thus, work that tackles the multidisciplinary and complex systems nature of periodontal disease is needed to help facilitate future preventative, mitigating, and restorative interventions based on biological, psychological, and socioeconomic mechanisms. During the F99 phase of this proposal, the awardee will continue through dissertation work, to examine a novel psycho- biological mechanism by exploring the role of the protein zonulin (modulator of tissue permeability) in periodontal parameters and its potential ability to explain the relation between psychological stress and periodontal disease. More specifically, the awardee will examine the relation of zonulin, as measured by serum, salivary, and gingival crevicular fluid ELISA, and periodontal disease parameters. Additionally, zonulin will be examined as a potential mediating and moderating factor in the relation between psychological stress and cytokines in periodontal examination participants. It is hypothesized that serum zonulin levels will mediate the relation between reports of psychological stress and various periodontal and inflammatory parameters (e.g., probing depth, attachment loss, IL-6 levels). In the K00 phase, the awardee will work in understanding the upstream socioeconomic (e.g., social networks) and psychological aspects (e.g., stress) of a biopsychosocial approach to understanding periodontal disease. It is hypothesized that people who report social connections with those they perceive to have poor oral health, who engage in risk behaviors (e.g. smoking, sugary diet), and who utilize dental care infrequently, will be more likely to report indicators of periodontal disease. Secondly, it is expected that poor psychological functioning will diminish social network effects. The F99 and K00 phases will utilize the training and mentorship gained as a predoctoral trainee and continuing to surround himself with mentors and in a multidisciplinary environment in his transition to the postdoctoral and early career stages of becoming an independent scholar. Thus, this award will facilitate the ability to identify novel biopsychosocial mechanisms in the development and progression of a complex oral disease through both its research and training plans.

项目总结 认识到治疗整个人的重要性，生物、心理和社会方法长期以来一直是 他是冠军。然而，健康和疾病研究的重点是生物异常。检视 从心理和社会行为角度看疾病增加了理解疾病的独特视角 任何特定疾病的病因和病程。也就是说，在阐明如何以及为什么这样做时，需要更多的理解。 生物、心理和社会因素可能加速疾病的发生。牙周病仍然是 全球最普遍的牙科、口腔和颅面疾病。患有牙周病的患者- 尤其是那些来自服务不足人群的人-面临着潜在的终身症状，这些症状会影响他们的 总体健康和生活质量。还需要额外的工作来表征解释 生物-心理-社会关系导致牙周病。因此，处理多学科和 牙周病的复杂系统性质需要帮助促进未来的预防、缓解和 基于生物、心理和社会经济机制的恢复性干预。在F99期间 在这个提案阶段，获奖者将继续进行论文工作，以检验一位新的精神病患者-- 通过探讨组织通透性调节因子--带状蛋白的作用探讨其生物学机制 牙周参数及其对心理应激与牙周疾病关系的潜在解释能力 牙周病。更具体地说，获奖者将检查zonlin的关系，通过 血清、唾液和牙周沟液的酶联免疫吸附试验和牙周病参数。此外，Zonlin 将被视为心理压力之间关系的一个潜在的中介和调节因素 牙周检查受试者的细胞因子水平。据推测，血清zonrin水平将在 心理应激报告与牙周及炎症参数的关系 (例如，探测深度、附着丧失、IL-6水平)。在K00阶段，获奖者将在理解中工作 上游社会经济(例如，社会网络)和心理方面(例如，压力) 了解牙周病的生物心理社会学方法。据推测，报告的人 与他们认为口腔健康状况不佳、从事危险行为的人建立社会关系(例如 吸烟、含糖饮食)，以及不经常使用牙齿护理的人，将更有可能报告 牙周病。其次，预计心理功能不佳会削弱社交网络 效果。F99和K00阶段将利用作为博士前实习生获得的培训和指导，以及 继续在导师的陪伴下，在多学科的环境中过渡到 成为独立学者的博士后和职业生涯早期阶段。因此，这一奖项将有助于 在复杂口腔的发生和发展中识别新的生物心理社会机制的能力 通过其研究和培训计划传播疾病。

项目成果

Food insecurity and consumption of cariogenic foods in mothers and their two-year-old children in Appalachia.

阿巴拉契亚地区母亲及其两岁儿童的粮食不安全和致龋食品的消费。

• DOI: 10.1111/jphd.12559
• 发表时间: 2023
• 期刊: Journal of public health dentistry
• 影响因子: 2.3
• 作者: Bhaumik,Deesha;Wright,CaseyD;Marshall,TeresaA;Neiswanger,Katherine;McNeil,DanielW;Jones,AndrewD;Shaffer,JohnR;Marazita,MaryL;Foxman,Betsy
• 通讯作者: Foxman,Betsy

Gastrointestinal distress as a potential mediator between stress and periodontal inflammation.

胃肠道不适是压力和牙周炎症之间的潜在中介。

• DOI: 10.1111/cdoe.12889
• 发表时间: 2023
• 期刊: Community dentistry and oral epidemiology
• 影响因子: 2.3
• 作者: Wright,CaseyD;Heaton,Brenda;Garcia,RaulI;Leonard,MaureenM;Fasano,Alessio;McNeil,DanielW
• 通讯作者: McNeil,DanielW