Building a multi-scale vascular atlas of the mouse lower urinary tract

摘要 该GUDMAP Atlas项目的重点是男性和女性的下尿路（LUT;膀胱和尿道）， 雌性老鼠具体目标是构建（1）小鼠LUT的3D多尺度解剖图谱 （2）该脉管系统的自主神经和感觉神经支配。生命周期的时间从 选择胚胎到成体来揭示器官结构和功能的主要变化的影响 关于血管模式目标1的成果将填补GUDMAP和更广泛文献中的一个重大空白， 其中与LUT肌肉壁相比，LUT血管结构未被充分探索， 上皮目标2的成果将为全球城市发展管理和评估方案提供第二个重要方面， 文献中，通过在血管图谱上叠加密切相关的轴突丛（感觉和 自主），调节LUT血管功能。这些轴突类别中的大多数并不起源于骨盆 ganglia，因此向GUDMAP数据库提供与现有资源截然不同的新资源 知识库除了发展关于血管系统的新知识外， 该项目将支持产生关于LUT在健康和疾病中的功能的新假设。 .

ABSTRACT This GUDMAP Atlas project is focused on the lower urinary tract (LUT; bladder and urethra) of male and female mice. The Specific Aims are to build 3D multiscale anatomical atlases of (1) the mouse LUT vasculature and (2) the autonomic and sensory innervation of this vasculature. Times of the life cycle from embryo to adult have been selected to reveal the impact of major changes in organ structure and function on vascular patterning. The outcomes of Aim 1 will fill a major gap in GUDMAP and the broader literature, where LUT vascular structures have been under-explored in comparison with LUT muscle wall and epithelium. The outcomes of Aim 2 will provide a second important dimension to GUDMAP and the literature, by superimposing on the vascular atlases the closely associated axonal plexuses (sensory and autonomic) that regulate LUT vascular function. Most of these axon classes do not originate from pelvic ganglia, so provide to the GUDMAP database new resources that are quite distinct from the existing knowledge base. In addition to developing new knowledge on the vascular system, the outcomes of the project will support generation of new hypotheses on LUT function in health and disease. .