Building a multi-scale vascular atlas of the mouse lower urinary tract

摘要 GUDMAP Atlas项目的重点是男性和女性的下尿路(LUT；膀胱和尿路)。 雌性老鼠。具体目标是建立(1)小鼠LUT的3D多尺度解剖图谱 血管系统和(2)该血管系统的自主神经和感觉神经支配。生命周期的时间 选择胚胎到成体，以揭示器官结构和功能的主要变化的影响 关于血管构图。目标1的成果将填补GUDMAP和更广泛文献中的一个重大空白， 与LUT肌壁和LUT相比，LUT血管结构探查不足 上皮组织。目标2的成果将为GUDMAP和 文献，通过在血管图谱上叠加紧密相关的轴突神经丛(感觉和 自主神经)调节LUT血管功能。这些轴突大多不是起源于骨盆 Ganglia，因此向GUDMAP数据库提供与现有资源截然不同的新资源 知识库。除了发展关于血管系统的新知识外， 该项目将支持LUT在健康和疾病中作用的新假说的产生。 。

ABSTRACT This GUDMAP Atlas project is focused on the lower urinary tract (LUT; bladder and urethra) of male and female mice. The Specific Aims are to build 3D multiscale anatomical atlases of (1) the mouse LUT vasculature and (2) the autonomic and sensory innervation of this vasculature. Times of the life cycle from embryo to adult have been selected to reveal the impact of major changes in organ structure and function on vascular patterning. The outcomes of Aim 1 will fill a major gap in GUDMAP and the broader literature, where LUT vascular structures have been under-explored in comparison with LUT muscle wall and epithelium. The outcomes of Aim 2 will provide a second important dimension to GUDMAP and the literature, by superimposing on the vascular atlases the closely associated axonal plexuses (sensory and autonomic) that regulate LUT vascular function. Most of these axon classes do not originate from pelvic ganglia, so provide to the GUDMAP database new resources that are quite distinct from the existing knowledge base. In addition to developing new knowledge on the vascular system, the outcomes of the project will support generation of new hypotheses on LUT function in health and disease. .