Building a multi-scale vascular atlas of the mouse lower urinary tract

建立小鼠下尿路多尺度血管图谱

基本信息

  • 批准号:
    10491153
  • 负责人:
  • 金额:
    $ 32.14万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-30 至 2026-07-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT This GUDMAP Atlas project is focused on the lower urinary tract (LUT; bladder and urethra) of male and female mice. The Specific Aims are to build 3D multiscale anatomical atlases of (1) the mouse LUT vasculature and (2) the autonomic and sensory innervation of this vasculature. Times of the life cycle from embryo to adult have been selected to reveal the impact of major changes in organ structure and function on vascular patterning. The outcomes of Aim 1 will fill a major gap in GUDMAP and the broader literature, where LUT vascular structures have been under-explored in comparison with LUT muscle wall and epithelium. The outcomes of Aim 2 will provide a second important dimension to GUDMAP and the literature, by superimposing on the vascular atlases the closely associated axonal plexuses (sensory and autonomic) that regulate LUT vascular function. Most of these axon classes do not originate from pelvic ganglia, so provide to the GUDMAP database new resources that are quite distinct from the existing knowledge base. In addition to developing new knowledge on the vascular system, the outcomes of the project will support generation of new hypotheses on LUT function in health and disease. .
摘要

项目成果

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JANET R KEAST其他文献

JANET R KEAST的其他文献

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{{ truncateString('JANET R KEAST', 18)}}的其他基金

Building a multi-scale vascular atlas of the mouse lower urinary tract
建立小鼠下尿路多尺度血管图谱
  • 批准号:
    10673913
  • 财政年份:
    2021
  • 资助金额:
    $ 32.14万
  • 项目类别:
Building a multi-scale vascular atlas of the mouse lower urinary tract
建立小鼠下尿路多尺度血管图谱
  • 批准号:
    10355551
  • 财政年份:
    2021
  • 资助金额:
    $ 32.14万
  • 项目类别:
Understanding functional connectivity of sensory and motor pathways to specific regions of the lower urinary tract.
了解感觉和运动通路与下尿路特定区域的功能连接。
  • 批准号:
    10211366
  • 财政年份:
    2016
  • 资助金额:
    $ 32.14万
  • 项目类别:
Understanding functional connectivity of sensory and motor pathways to specific regions of the lower urinary tract.
了解感觉和运动通路与下尿路特定区域的功能连接。
  • 批准号:
    9532342
  • 财政年份:
    2016
  • 资助金额:
    $ 32.14万
  • 项目类别:
Understanding functional connectivity of sensory and motor pathways to specific regions of the lower urinary tract.
了解感觉和运动通路与下尿路特定区域的功能连接。
  • 批准号:
    9920329
  • 财政年份:
    2016
  • 资助金额:
    $ 32.14万
  • 项目类别:
Understanding functional connectivity of sensory and motor pathways to specific regions of the lower urinary tract.
了解感觉和运动通路与下尿路特定区域的功能连接。
  • 批准号:
    10410796
  • 财政年份:
    2016
  • 资助金额:
    $ 32.14万
  • 项目类别:
Molecular and spatial mapping of bladder nociceptors during development and matur
膀胱伤害感受器在发育和成熟过程中的分子和空间图谱
  • 批准号:
    8635404
  • 财政年份:
    2013
  • 资助金额:
    $ 32.14万
  • 项目类别:
High resolution mapping of lower urinary tract innervation during development
发育过程中下尿路神经支配的高分辨率绘图
  • 批准号:
    8543627
  • 财政年份:
    2011
  • 资助金额:
    $ 32.14万
  • 项目类别:
High resolution mapping of lower urinary tract innervation during development
发育过程中下尿路神经支配的高分辨率绘图
  • 批准号:
    8730770
  • 财政年份:
    2011
  • 资助金额:
    $ 32.14万
  • 项目类别:
High resolution mapping of lower urinary tract innervation during development
发育过程中下尿路神经支配的高分辨率绘图
  • 批准号:
    8411358
  • 财政年份:
    2011
  • 资助金额:
    $ 32.14万
  • 项目类别:

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