Building a multi-scale vascular atlas of the mouse lower urinary tract
Building a multi-scale vascular atlas of the mouse lower urinary tract
批准号:
10491153
负责人:
JANET R KEAST
金额:
$32.14万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-09-30 至 2026-07-31
关键词:
3-DimensionalAddressAdultAnatomyAtlasesAxonBladderBladder ControlBlood VesselsClinicalClinical MedicineCommunitiesComplexComputer ModelsCongestiveCustomDataData CollectionDatabasesDevelopmentDiabetes MellitusDimensionsDiseaseEmbryoEnvironmentEpithelialFAIR principlesFemaleFluid BalanceFoundationsGangliaGenerationsGraphGrowthHealthImmunologic SurveillanceKnowledgeLectinLife Cycle StagesLightLiteratureLower urinary tractLymphaticMapsMethodologyMethodsMicroscopyMusMuscleNerveNerve PlexusOrganOutcomeOutputPatternPelvisPerfusionPregnancyRegulationResearchResolutionResourcesRodentSamplingSensorySourceStretchingStructureSyndromeSystemThickThree-Dimensional ImageTimeTissue EngineeringTissuesUrethraValidationVascular SystemVenousVenous systemViralVisualizationWeaningbasedesignhuman dataimmature animalknowledge basemalemulti-scale atlasnerve supplyneurovascularnovel strategiesprepubertypressurerelating to nervous systemtoolurinary bladder neck
中文摘要
摘要
GUDMAP Atlas项目的重点是男性和女性的下尿路(LUT;膀胱和尿路)。
雌性老鼠。具体目标是建立(1)小鼠LUT的3D多尺度解剖图谱
血管系统和(2)该血管系统的自主神经和感觉神经支配。生命周期的时间
选择胚胎到成体,以揭示器官结构和功能的主要变化的影响
关于血管构图。目标1的成果将填补GUDMAP和更广泛文献中的一个重大空白,
与LUT肌壁和LUT相比,LUT血管结构探查不足
上皮组织。目标2的成果将为GUDMAP和
文献,通过在血管图谱上叠加紧密相关的轴突神经丛(感觉和
自主神经)调节LUT血管功能。这些轴突大多不是起源于骨盆
Ganglia,因此向GUDMAP数据库提供与现有资源截然不同的新资源
知识库。除了发展关于血管系统的新知识外,
该项目将支持LUT在健康和疾病中作用的新假说的产生。
。
英文摘要
ABSTRACT
This GUDMAP Atlas project is focused on the lower urinary tract (LUT; bladder and urethra) of male and
female mice. The Specific Aims are to build 3D multiscale anatomical atlases of (1) the mouse LUT
vasculature and (2) the autonomic and sensory innervation of this vasculature. Times of the life cycle from
embryo to adult have been selected to reveal the impact of major changes in organ structure and function
on vascular patterning. The outcomes of Aim 1 will fill a major gap in GUDMAP and the broader literature,
where LUT vascular structures have been under-explored in comparison with LUT muscle wall and
epithelium. The outcomes of Aim 2 will provide a second important dimension to GUDMAP and the
literature, by superimposing on the vascular atlases the closely associated axonal plexuses (sensory and
autonomic) that regulate LUT vascular function. Most of these axon classes do not originate from pelvic
ganglia, so provide to the GUDMAP database new resources that are quite distinct from the existing
knowledge base. In addition to developing new knowledge on the vascular system, the outcomes of the
project will support generation of new hypotheses on LUT function in health and disease.
.
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Building a multi-scale vascular atlas of the mouse lower urinary tract
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批准号:10673913
-
项目类别:
-
资助金额:$32.14万
-
财政年份:2021
-
负责人:JANET R KEAST
-
依托单位:
Building a multi-scale vascular atlas of the mouse lower urinary tract
-
批准号:10355551
-
项目类别:
-
资助金额:$31.98万
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财政年份:2021
-
负责人:JANET R KEAST
-
依托单位:
Understanding functional connectivity of sensory and motor pathways to specific regions of the lower urinary tract.
-
批准号:10211366
-
项目类别:
-
资助金额:$108.77万
-
财政年份:2016
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负责人:JANET R KEAST
-
依托单位:
Understanding functional connectivity of sensory and motor pathways to specific regions of the lower urinary tract.
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批准号:9532342
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项目类别:
-
资助金额:$45.29万
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财政年份:2016
-
负责人:JANET R KEAST
-
依托单位:
Understanding functional connectivity of sensory and motor pathways to specific regions of the lower urinary tract.
-
批准号:9920329
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项目类别:
-
资助金额:$9.72万
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财政年份:2016
-
负责人:JANET R KEAST
-
依托单位:
Understanding functional connectivity of sensory and motor pathways to specific regions of the lower urinary tract.
-
批准号:10410796
-
项目类别:
-
资助金额:$147.47万
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财政年份:2016
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负责人:JANET R KEAST
-
依托单位:
Molecular and spatial mapping of bladder nociceptors during development and matur
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批准号:8635404
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项目类别:
-
资助金额:$19.4万
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财政年份:2013
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负责人:JANET R KEAST
-
依托单位:
High resolution mapping of lower urinary tract innervation during development
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批准号:8543627
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项目类别:
-
资助金额:$15.39万
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财政年份:2011
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负责人:JANET R KEAST
-
依托单位:
High resolution mapping of lower urinary tract innervation during development
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批准号:8730770
-
项目类别:
-
资助金额:$10.8万
-
财政年份:2011
-
负责人:JANET R KEAST
-
依托单位:
High resolution mapping of lower urinary tract innervation during development
-
批准号:8411358
-
项目类别:
-
资助金额:$13.77万
-
财政年份:2011
-
负责人:JANET R KEAST
-
依托单位:
High resolution mapping of lower urinary tract innervation during development
-
批准号:8334381
-
项目类别:
-
资助金额:$18.35万
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财政年份:2011
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负责人:JANET R KEAST
-
依托单位:
Effects of estrogens on bladder pain
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批准号:6965200
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项目类别:
-
资助金额:$18.45万
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财政年份:2005
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负责人:JANET R KEAST
-
依托单位:
Effects of estrogens on bladder pain
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批准号:7462440
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项目类别:
-
资助金额:$17.14万
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财政年份:2005
-
负责人:JANET R KEAST
-
依托单位:
Effects of estrogens on bladder pain
-
批准号:7653626
-
项目类别:
-
资助金额:$17.14万
-
财政年份:2005
-
负责人:JANET R KEAST
-
依托单位:
Effects of estrogens on bladder pain
-
批准号:7257213
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项目类别:
-
资助金额:$17.49万
-
财政年份:2005
-
负责人:JANET R KEAST
-
依托单位:
Effects of estrogens on bladder pain
-
批准号:7106395
-
项目类别:
-
资助金额:$18.02万
-
财政年份:2005
-
负责人:JANET R KEAST
-
依托单位:
海外基金