NeuroDev Kenya: characterizing the epidemiology and etiology of developmental disorders on the Kenyan Coast

项目摘要/摘要 NeuroDev肯尼亚数据集将提供一个前所未有的机会来研究糖尿病的病因学 在东非开发神经发育障碍(NDDS)，并创造具有国际价值的研究资源。它 将是非洲农村地区第一个具有深刻表型和遗传特征的大规模NDD收集 提供信息，所有数据和材料都将向公众开放。在本申请中，我们建议 对NeuroDev肯尼亚的遗传和表型数据进行广泛的分析，从该奖项的 第二年。分析将利用KEMRI的丰富环境，并将与我们的 拟议的能力建设活动(目标3)。通过我们的能力建设活动，我们将提供有组织的 在遗传学和遗传数据分析方面的培训，决定是否引入淋巴母细胞系(LCL) 协议进入NeuroDev肯尼亚，并决定如何从道德上包括患有ID的成年人。我们将分享所有数据 (例如，表型、基因类型)和材料(例如，来自血液的DNA，可能是LCLS)。我们会 还通过国际财团和正式确定的新的非洲NDD研究网络分享成果 通过这个奖项(目标4)。

Project Summary/Abstract The NeuroDev Kenya data set will provide an unprecedented opportunity to study the etiology of neurodevelopmental disorders (NDDs) in East Africa, and create a research resource of international value. It will be the first large-scale NDD collection in a rural African setting that is deeply phenotyped and genetically informative, and all data and materials will be made publicly available. In this application, we propose to conduct extensive analysis of NeuroDev Kenya’s genetic and phenotypic data, beginning in the award’s second year. The analyses will leverage the rich environment at KEMRI and will be intertwined with our proposed capacity building activities (Aim 3). Through our capacity building activities, we will provide structured training in genetics and genetic data analysis, determine whether to introduce a lymphoblastic cell line (LCL) protocol into NeuroDev Kenya, and determine how to ethically include adults with ID. We will share all data (e.g. phenotypes, genotypes), and materials (e.g. DNA from blood, possibly LCLs) through the NIH. We will also share outputs through international consortia and a new African NDD Research Network formalized through this award (Aim 4).