NeuroDev Kenya: characterizing the epidemiology and etiology of developmental disorders on the Kenyan Coast

项目概要/摘要 NeuroDev肯尼亚数据集将提供一个前所未有的机会来研究 神经发育障碍（NDD）在东非，并创建一个具有国际价值的研究资源。它 这将是非洲农村地区第一次大规模收集NDD， 所有数据和材料都将公开提供。在本申请中，我们建议 对NeuroDev Kenya的遗传和表型数据进行广泛分析，从该奖项的 二年这些分析将利用KEMRI丰富的环境，并与我们的 能力建设活动（目标3）。通过我们的能力建设活动，我们将提供结构化的 遗传学和遗传数据分析培训，确定是否引入淋巴母细胞系（LCL） 协议到NeuroDev肯尼亚，并确定如何在道德上包括成年人与ID。我们将分享所有数据 (e.g.表型、基因型）和材料（例如来自血液的DNA，可能是LCL）通过NIH。我们将 我还通过国际财团和正式成立的新的非洲NDD研究网络分享成果 通过这个奖项（目标4）。

Project Summary/Abstract The NeuroDev Kenya data set will provide an unprecedented opportunity to study the etiology of neurodevelopmental disorders (NDDs) in East Africa, and create a research resource of international value. It will be the first large-scale NDD collection in a rural African setting that is deeply phenotyped and genetically informative, and all data and materials will be made publicly available. In this application, we propose to conduct extensive analysis of NeuroDev Kenya’s genetic and phenotypic data, beginning in the award’s second year. The analyses will leverage the rich environment at KEMRI and will be intertwined with our proposed capacity building activities (Aim 3). Through our capacity building activities, we will provide structured training in genetics and genetic data analysis, determine whether to introduce a lymphoblastic cell line (LCL) protocol into NeuroDev Kenya, and determine how to ethically include adults with ID. We will share all data (e.g. phenotypes, genotypes), and materials (e.g. DNA from blood, possibly LCLs) through the NIH. We will also share outputs through international consortia and a new African NDD Research Network formalized through this award (Aim 4).