NeuroDev Kenya: characterizing the epidemiology and etiology of developmental disorders on the Kenyan Coast

项目概要/摘要 NeuroDev Kenya 数据集将为研究病因提供前所未有的机会 东非的神经发育障碍（NDD），并创造具有国际价值的研究资源。它 将是非洲农村地区第一个大规模的 NDD 收集，该收集具有深刻的表型和遗传特征 信息丰富，所有数据和材料都将公开。在本申请中，我们建议 从奖项颁发开始，对 NeuroDev Kenya 的遗传和表型数据进行广泛的分析 第二年。这些分析将利用 KEMRI 的丰富环境，并将与我们的 拟议的能力建设活动（目标 3）。通过我们的能力建设活动，我们将提供结构化的 遗传学和遗传数据分析方面的培训，确定是否引入淋巴细胞系（LCL） 肯尼亚 NeuroDev 协议，并确定如何以合乎道德的方式将患有智力障碍的成年人纳入其中。我们将共享所有数据 （例如表型、基因型）和材料（例如血液中的 DNA，可能是 LCL）通过 NIH。我们会 还通过国际财团和正式成立的新非洲 NDD 研究网络分享成果 通过这个奖项（目标 4）。

Project Summary/Abstract The NeuroDev Kenya data set will provide an unprecedented opportunity to study the etiology of neurodevelopmental disorders (NDDs) in East Africa, and create a research resource of international value. It will be the first large-scale NDD collection in a rural African setting that is deeply phenotyped and genetically informative, and all data and materials will be made publicly available. In this application, we propose to conduct extensive analysis of NeuroDev Kenya’s genetic and phenotypic data, beginning in the award’s second year. The analyses will leverage the rich environment at KEMRI and will be intertwined with our proposed capacity building activities (Aim 3). Through our capacity building activities, we will provide structured training in genetics and genetic data analysis, determine whether to introduce a lymphoblastic cell line (LCL) protocol into NeuroDev Kenya, and determine how to ethically include adults with ID. We will share all data (e.g. phenotypes, genotypes), and materials (e.g. DNA from blood, possibly LCLs) through the NIH. We will also share outputs through international consortia and a new African NDD Research Network formalized through this award (Aim 4).