CRST COVID-19 - Wayakta He

标题：CRST COVID-19 Wayakta He？(Are你对COVID有什么防范？）PI：E.埃尔代伊 项目摘要 严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）的持续并发大流行 来自电子烟和二手烟的感染和毒性暴露已经 对美国少数民族社区的毁灭性打击，而不是由于普遍的 由于缺乏免疫力，有证据表明，COVID-19疾病的负担不成比例地受到了 种族/少数民族和低收入社区。这种最明显和最新的健康差距可能是由于 各种心理社会压力源源于结构性不平等，使有色人种和/或 社会经济地位低，包括美洲印第安人/阿拉斯加原住民社区， SARS-CoV-2感染的收缩和COVID-19疾病的严重程度。最近的一份文献表明， 总体COVID-19诊断与年轻人使用电子烟有关。然而，这项研究并没有看到 特别是在年轻一代的美国印第安人和阿拉斯加原住民（AI/AN），以及其他因素如何在 部落社区影响疾病易感性。本提案是针对“建立机制， 环境健康科学中的时间敏感研究机会“，RFA-ES-19-011。目标1将 在夏延地区采用基于社区的社会经济和环境压力源数据收集 南达科他州的苏族河部落（CRST）社区进行部落调查， 构成在300个参与CRST家庭中收集的CRST SARS-CoV-2感染流行率， 600名不同的参与者代表了广泛的年龄范围（18-89岁）。小说与时代的发展- 在持续的CRSRT流行期间，关于社会因素和环境毒物的敏感数据将扩大 根据目标2，通过捕捉详细的个人行为（即vaping），压力源，部落住房，并通过测量 可能影响COVID-19疾病易感性、严重程度和免疫反应的环境健康因素。 将进行详细的免疫学评估（总伊加、病毒特异性IgG和IgM阳性和皮质醇） 通过非侵入性的唾液取样。这些措施将帮助我们评估风险之间的关联 Aim 1调查数据和RT-PCR证实SARS-CoV-2病毒感染流行的因素。基于 被动空气监测，我们将能够评估空气中暴露于氮之间的关联， 二氧化物和空气中的尼古丁，增加了对SARS-CoV-2感染的易感性， 病毒特异性IgM增加，保护性IgG应答降低。我们将协助CRST COVID-19 指挥中心通过产生社区驱动的，有针对性的COVID-19，公共卫生素养， 获取基于人群的感染易感性风险和特异性免疫应答数据。我们的假设是 CRST社区成员中SARS-CoV-2感染的增加与电子烟有关， 室内二手烟，社会经济地位较低，家庭使用的热源类型，大 多代同堂的家庭（一个家庭中有3.4人以上），居住在多单元的部落住宅区。

Title: CRST COVID-19 Wayakta He? (Are you on guard against COVID?) PI: E. Erdei Project Summary Ongoing concurrent pandemics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections and toxic exposures originated from electronic cigarette (e-cig) and secondhand smoke had taken devastating tolls on minority communities in the U.S. Rather than being “the great equalizer” due to universal lack of immunity, evidence has shown that the burden of COVID-19 disease has been disproportionately felt by racial/ethnic minority and low-income communities. This stark and most current health disparity is likely due to a variety of psychosocial stressors stemming from structural inequalities that place individuals of color and/or low socioeconomic status, including American Indian/Alaska Native communities at greater risk for the contraction of SARS-CoV-2 infection and severity of COVID-19 disease. A recent literature showed that overall COVID-19 diagnosis was associated with youth use of e-cigarettes. However, that study did not look specifically at younger generation of American Indian and Alaskan Native (AI/AN), and how other factors within tribal communities affect disease susceptibility. This proposal is submitted in response to "Mechanism for Time-Sensitive Research Opportunities in Environmental Health Sciences ", RFA-ES-19-011. Aim 1 will employ a community-based data collection of socioeconomic and environmental stressors in the Cheyenne River Sioux Tribal (CRST) communities in South Dakota by administering a tribal-specific survey, which will constitute the CRST SARS-CoV-2 infection prevalence collected in 300 participating CRST households with 600 distinct participants representing a wide-range of ages (18-89 yrs). The development of novel and time - sensitive data during the ongoing CRSRT pandemic on social factors and environmental toxicants will expand under Aim 2 by capturing detailed personal behaviors (i.e. vaping), stressors, Tribal housing, and by measuring environmental health factors that may impact COVID-19 disease susceptibility, severity and immune response. Detailed immunological assessment (total IgA, viral-specific IgG & IgM positivities and cortisol) will be carried out by using non-invasive saliva sampling. These measures will help us to assess the association between risk factors from Aim 1 survey data and RT-PCR confirmed SARS-CoV-2 viral infection prevalence. Based on passive air monitoring we will be able to evaluate the association between airborne exposures to nitrogen dioxide and airborne nicotine in the homes with increased susceptibility for SARS-CoV-2 infections and increased viral-specific IgM and decreased protective IgG response. We will assist CRST COVID-19 Command Center by generating a community-driven, COVID-19 targeted, public health literacy, and by capturing population-based infection susceptibility risks and specific immune response data. Our hypothesis is that increased SARS-CoV-2 infections among CRST community members are associated with vaping and indoor secondhand smoke, lower socioeconomic status, the type of heating sources used in homes, large multigenerational households (>3.4 people in one home), and living in multi-unit Tribal housing complexes.