CRST COVID-19 - Wayakta He

标题：CRST新冠肺炎Wayakta他？(你对新冠肺炎有戒备吗？)派：E.Erdei 项目摘要 持续同时流行的严重急性呼吸系统综合症冠状病毒2型 由电子烟(e-cig)和二手烟引起的感染和有毒接触 美国少数族裔社区的毁灭性通行费，而不是由于普遍存在而成为“伟大的均衡器” 缺乏免疫力，有证据表明，新冠肺炎的负担已经不成比例地感受到了 种族/少数民族和低收入社区。这种明显的和目前最严重的健康差距很可能是由于 各种心理社会应激源，源于结构性不平等，将有色人种和/或 社会经济地位低，包括美洲印第安人/阿拉斯加原住民社区面临更大的 SARS-CoV-2感染与新冠肺炎严重程度的关系最近的一篇文献表明， 总体来说，新冠肺炎的诊断与年轻人使用电子烟有关。然而，这项研究并没有看起来 尤其是年轻一代的美国印第安人和阿拉斯加原住民(AI/AN)，以及 部落社区影响疾病的易感性。本提案是为响应《机制》而提出的 环境健康科学中时间敏感的研究机会“，RFA-ES-19-011。目标1将 利用基于社区的数据收集夏延族的社会经济和环境压力来源 通过管理一项部落调查，在南达科他州的苏河部落(CRST)社区，这将 构成CRST SARS-CoV-2感染流行情况的300个参与CRST家庭中 600名不同的参与者，代表不同的年龄范围(18-89岁)。小说和时间的发展- 正在进行的CRSRT大流行期间有关社会因素和环境毒物的敏感数据将扩大 在目标2下，通过捕获详细的个人行为(即蒸发)、压力源、部落住房和测量 可能影响新冠肺炎疾病易感性、严重程度和免疫反应的环境卫生因素。 将进行详细的免疫学评估(总免疫球蛋白A、病毒特异性免疫球蛋白和免疫球蛋白M阳性和皮质醇) 通过使用非侵入性唾液样本进行检测。这些措施将有助于我们评估风险之间的关联 来自AIM 1调查数据和RT-PCR的因素证实了SARS-CoV-2病毒感染的流行。基于 被动空气监测我们将能够评估空气中氮气暴露之间的联系 感染SARS-CoV-2易感性增加的家庭中的二氧化碳和空气中的尼古丁 病毒特异性IgM升高，保护性免疫球蛋白应答降低。我们将协助中国中车新冠肺炎 指挥中心通过产生以社区为导向、新冠肺炎有针对性的公共卫生素养，并通过 获取基于人群的感染易感性风险和特定的免疫反应数据。我们的假设是 CRST社区成员SARS-CoV-2感染增加与蒸发和 室内二手烟，社会经济地位较低，家庭使用的热源类型，大型 多代家庭(一户3.4人)，居住在多单元部落住宅区。

Title: CRST COVID-19 Wayakta He? (Are you on guard against COVID?) PI: E. Erdei Project Summary Ongoing concurrent pandemics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections and toxic exposures originated from electronic cigarette (e-cig) and secondhand smoke had taken devastating tolls on minority communities in the U.S. Rather than being “the great equalizer” due to universal lack of immunity, evidence has shown that the burden of COVID-19 disease has been disproportionately felt by racial/ethnic minority and low-income communities. This stark and most current health disparity is likely due to a variety of psychosocial stressors stemming from structural inequalities that place individuals of color and/or low socioeconomic status, including American Indian/Alaska Native communities at greater risk for the contraction of SARS-CoV-2 infection and severity of COVID-19 disease. A recent literature showed that overall COVID-19 diagnosis was associated with youth use of e-cigarettes. However, that study did not look specifically at younger generation of American Indian and Alaskan Native (AI/AN), and how other factors within tribal communities affect disease susceptibility. This proposal is submitted in response to "Mechanism for Time-Sensitive Research Opportunities in Environmental Health Sciences ", RFA-ES-19-011. Aim 1 will employ a community-based data collection of socioeconomic and environmental stressors in the Cheyenne River Sioux Tribal (CRST) communities in South Dakota by administering a tribal-specific survey, which will constitute the CRST SARS-CoV-2 infection prevalence collected in 300 participating CRST households with 600 distinct participants representing a wide-range of ages (18-89 yrs). The development of novel and time - sensitive data during the ongoing CRSRT pandemic on social factors and environmental toxicants will expand under Aim 2 by capturing detailed personal behaviors (i.e. vaping), stressors, Tribal housing, and by measuring environmental health factors that may impact COVID-19 disease susceptibility, severity and immune response. Detailed immunological assessment (total IgA, viral-specific IgG & IgM positivities and cortisol) will be carried out by using non-invasive saliva sampling. These measures will help us to assess the association between risk factors from Aim 1 survey data and RT-PCR confirmed SARS-CoV-2 viral infection prevalence. Based on passive air monitoring we will be able to evaluate the association between airborne exposures to nitrogen dioxide and airborne nicotine in the homes with increased susceptibility for SARS-CoV-2 infections and increased viral-specific IgM and decreased protective IgG response. We will assist CRST COVID-19 Command Center by generating a community-driven, COVID-19 targeted, public health literacy, and by capturing population-based infection susceptibility risks and specific immune response data. Our hypothesis is that increased SARS-CoV-2 infections among CRST community members are associated with vaping and indoor secondhand smoke, lower socioeconomic status, the type of heating sources used in homes, large multigenerational households (>3.4 people in one home), and living in multi-unit Tribal housing complexes.