Administrative Core

核心A摘要 管理核心的目的是监督各个实验室的管理责任 本P01中项目1、2和3概述的研究。行政核心将提供高水平的 对项目的组织支持，包括提供必要的资源、财政监督、遵守 机构和NIH指南/法规。行政核心将进一步协调定期联合 传播成果、讨论科学挑战和发现创新解决方案的会议，以推动 科学。管理核心将负责整合样本收集和临床因素的科学努力 通过(1)协调样品跟踪和(2)检索和分析项目内和项目之间的分析 与DFCI内外的机构收集所有3个项目的数据。行政核心也是 负责提交/维护与样品有关的法规文件。这个 行政核心将进一步促进重大研究成果迅速传播到科学 社区。这些活动将有助于加强丰富的科学工作在内部和之间的整合。 项目，并促进将调查结果转化为病人护理环境；反过来，启动 实验室研究来源于临床观察和在所有3个项目中获得的组织样本。总而言之， 这些项目的这一中央资源将加强调查小组之间的互动，以促进 该计划的翻译目标和愿景是将基因组、功能和临床信息整合在一起 患有里氏综合征的患者。

Core A Summary Abstract The purpose of the Administrative Core is to oversee the administrative responsibilities of the various laboratory studies outlined in the Projects 1, 2 and 3 in this P01. The Administrative Core will provide high-level organizational support for the Projects, including provision of necessary resources, fiscal oversight, adherence to institutional and NIH guidelines/regulations. The Administrative Core will further coordinate regular joint meetings to disseminate results, discuss scientific challenges, and discover innovative solutions to advance the science. The Administrative Core will serve to integrate scientific efforts for sample collection and clinical factor analysis within and between Projects through the (i) coordination of sample tracking and (ii) the retrieval and data collection for all 3 Projects with institutions both within and outside of DFCI. The Administrative Core also has responsibility for the submission/maintenance of regulatory documents related to samples. The Administrative Core will further promote the rapid dissemination of significant research findings to the scientific community. These activities will serve to enhance the integration of the rich scientific efforts within and between Projects, and foster the translation of findings to the patient care setting; and conversely, the initiation of laboratory studies stemming from clinical observations and tissue samples obtained in all 3 projects. Altogether, this central resource for the Projects will enhance interactions among the investigative teams to further the translational goals and vision of this Program for integrating genomic, functional and clinical information of patients with Richter's Syndrome.