Molecular Regulation of B cells and T cells in Human SLE

人类 SLE 中 B 细胞和 T 细胞的分子调控

• 批准号: 10493525
• 负责人: Ignacio E. Sanz
• 金额: $ 8.88万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10493525
• 关键词: Antigens; Antitumor Response; Autoantigens; Autoimmune; Autoimmune Diseases; Autoimmune Responses; Autoimmunity; B cell differentiation; B-Cell Development; B-Lymphocytes; Biological Markers; CD8-Positive T-Lymphocytes; Cancer Patient; Categories; Cell physiology; Cells; Chronic; Clinical; Clinical Protocols; Clinical Research; Collaborations; Committee Members; Comparative Study; Development; Diagnosis; Disease; Effector Cell; Epigenetic Process; Evolution; Funding; Genetic Predisposition to Disease; Goals; Heterogeneity; Human; Immune; Immune checkpoint inhibitor; Immune response; Immunologics; Individual; Knowledge; Lead; Leadership; Location; Lupus; Maintenance; Mission; Molecular; Onset of illness; Outcome; PD-1 blockade; Pathogenesis; Pathogenicity; Pathway interactions; Patients; Physicians; Pilot Projects; Population; Process; Regulation; Resources; Scientist; Systemic Lupus Erythematosus; T-Lymphocyte; Translating; Universities; Virus Diseases; Work; arm; autoreactive B cell; base; clinical development; design; epigenetic regulation; epigenome; exhaustion; experience; immunogenic; imprint; innovation; novel; operation; personalized medicine; programs; response; self-renewal; stem; stem-like cell

Abstract The Emory ACE Fund Management Core (EAFMC) at Emory University proposes to manage on behalf of the ACE network two funds. The first will be the Clinical Project Fund, which will support all of the Clinical Projects (ClinProj) within the ACE. The second will be the Collaborative Research Fund (CRF). The CRF will provide funding support for the Collaborative Projects of the ACE, as well as additional studies that are added for achieving the ACE research agenda. It is estimated from the RFA that the AFMC will manage $3.2M in direct costs associated with these projects and that these will occur through about 100 consortium agreements emanating from up to 50 different sites. It will accomplish this through the following aims: (1) Establishing an effective administrative structure and operating unit, (2) developing plans to effectively produce and execute budgets and consortium agreements, (3) establish templates for the ClinProj and CRP budget agreements, (4) develop procedures to pay invoices and resolve problems; and (5) develop procedures for accountability, communication, and reporting to the ACE Steering committee and NIAID.

摘要