Molecular Regulation of B cells and T cells in Human SLE

人类 SLE 中 B 细胞和 T 细胞的分子调控

• 批准号: 10493525
• 负责人: Ignacio E. Sanz
• 金额: $ 8.88万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10493525
• 关键词: Antigens; Antitumor Response; Autoantigens; Autoimmune; Autoimmune Diseases; Autoimmune Responses; Autoimmunity; B cell differentiation; B-Cell Development; B-Lymphocytes; Biological Markers; CD8-Positive T-Lymphocytes; Cancer Patient; Categories; Cell physiology; Cells; Chronic; Clinical; Clinical Protocols; Clinical Research; Collaborations; Committee Members; Comparative Study; Development; Diagnosis; Disease; Effector Cell; Epigenetic Process; Evolution; Funding; Genetic Predisposition to Disease; Goals; Heterogeneity; Human; Immune; Immune checkpoint inhibitor; Immune response; Immunologics; Individual; Knowledge; Lead; Leadership; Location; Lupus; Maintenance; Mission; Molecular; Onset of illness; Outcome; PD-1 blockade; Pathogenesis; Pathogenicity; Pathway interactions; Patients; Physicians; Pilot Projects; Population; Process; Regulation; Resources; Scientist; Systemic Lupus Erythematosus; T-Lymphocyte; Translating; Universities; Virus Diseases; Work; arm; autoreactive B cell; base; clinical development; design; epigenetic regulation; epigenome; exhaustion; experience; immunogenic; imprint; innovation; novel; operation; personalized medicine; programs; response; self-renewal; stem; stem-like cell

Abstract The Emory ACE Fund Management Core (EAFMC) at Emory University proposes to manage on behalf of the ACE network two funds. The first will be the Clinical Project Fund, which will support all of the Clinical Projects (ClinProj) within the ACE. The second will be the Collaborative Research Fund (CRF). The CRF will provide funding support for the Collaborative Projects of the ACE, as well as additional studies that are added for achieving the ACE research agenda. It is estimated from the RFA that the AFMC will manage $3.2M in direct costs associated with these projects and that these will occur through about 100 consortium agreements emanating from up to 50 different sites. It will accomplish this through the following aims: (1) Establishing an effective administrative structure and operating unit, (2) developing plans to effectively produce and execute budgets and consortium agreements, (3) establish templates for the ClinProj and CRP budget agreements, (4) develop procedures to pay invoices and resolve problems; and (5) develop procedures for accountability, communication, and reporting to the ACE Steering committee and NIAID.

摘要 埃默里大学的埃默里ACE基金管理核心(EAFMC)建议管理 代表ACE网络的两只基金。第一个是临床项目基金，它将支持 ACE内的所有临床项目(ClinProj)。第二个将是协作型 研究基金(CRF)。合作研究基金将为合作项目提供资助 ACE，以及为实现ACE研究议程而增加的其他研究。它是 根据RFA估计，AFMC将管理与这些项目相关的320万美元的直接成本 这些项目将通过UP产生的大约100个财团协议进行 到50个不同的地点。它将通过以下目标实现这一目标：(1)建立有效的 管理结构和运营单位，(2)制定计划，有效地生产和运营 执行预算和联合体协议，(3)为ClinProj和CRP建立模板 预算协议，(4)制定支付发票和解决问题的程序；和(5) 制定向ACE指导负责、沟通和报告的程序 委员会和NIAID。