Administrative Core

行政核心A摘要。 通过强有力的行政结构进行协调领导是 复杂的多实验室项目。对于涉及人类研究的项目来说尤其如此，因为有 必须满足的其他招聘、安全和监管方面的问题。核心A的目的是为了促进 PPG的项目在了解支持浆细胞发育和 它在疾病中的失调。为了达到这一目标，我们将继续建设和完善基础设施。 在过去的5年里，我们一直在为这个PPG的管理而发展。核心的功能 A将继续提供行政支助、组织、协调和有效管理 这一PPG的首要目标是确保所有项目的科学生产力。 核心A将由Iñaki Sanz博士(整体P.I.和项目4负责人)执导，他除了是一个世界 人类B细胞生物学的一流专家，也在指导多名研究人员方面积累了丰富的经验 过去20年的研究计划。他将得到两名招聘的专家工作人员的协助；艾米博士 Stout，具有提供行政和财务支持以及监督多中心的丰富经验 埃默里大学的项目和桑乐女士，她有15年的标本收集经验 计划，并在Emory IRB系统内进行大型临床试验。通过行政监督和 指导，我们将确保适当和及时的财政管理和有效地使用人力和财力 资源。 核心A将确保所有员工和支持人员都经过培训，并获得机构安全认证 审查委员会，以及机构动物护理和使用目的。核心A还将跟踪学习入学人数和 持续审查PI的登记情况，以确保总体患者招募目标和时间表符合 被遇见了。核心将继续通过结构化的月度提供科学协调和互动， 每季度和每年举行一次会议，并将监测项目进展情况，并协助绩效指标编制年度进展报告。 此外，还将由一个由资深免疫学家组成的外部咨询委员会提供监督 在B细胞生物学、耐受性、炎症和表观遗传学方面拥有广泛的相关专业知识。核心A将促进 PPG领导层与外部咨询委员会之间通过规划和执行 年度会议，旨在提供项目更新，讨论正在进行的和未来的研究，并实现目标 对计划整体状态的反馈。核心还将确保及时传播成果和数据 通过项目演示和出版目标进行分享。通过精简和整合行政管理 任务，并提供战略领导以及内部和外部协调，核心A将启用项目绩效指标 合作产生严谨和有影响力的科学发现，以增加我们对等离子体的了解 细胞，并对人类健康产生积极影响。 1

ADMINISTRATIVE CORE A ABSTRACT. Coordinated leadership through a strong administrative structure is an essential component of the success of complex multiple-laboratory projects. This is particularly true for projects involving human research as there are additional recruitment, safety, and regulatory concerns that must be met. The purpose of Core A is to facilitate progress of the projects of the PPG in understanding the processes that underly plasma cell development and its dysregulation in disease. To accomplish this objective, we will continue to build and refine the infrastructure that we have been developing over the previous 5 years for the administration of this PPG. The function of Core A will continue to be to provide administrative support, organization, coordination and efficient management of this PPG with the overarching goal of ensuring the scientific productivity of all projects. Core A will be directed by Dr. Iñaki Sanz (overall P.I., and Project 4 Leader), who in addition to being a world class expert on human B cell biology, has also accumulated substantial experience in directing multi-investigator research programs over the past 20 years. He will be assisted by two recruited expert staff members; Dr. Amy Stout who has extensive experience providing administrative and financial support and overseeing multi-center projects at Emory University and Ms. Sang Le who has 15 years experience overseeing specimen collection programs and enabling large clinical trials within the Emory IRB system. Through administrative oversight and guidance, we will ensure proper and timely fiscal management and efficient use of human and financial resources. Core A will make sure that all staff and support personnel are trained and accredited for safety, Institutional Review Board, and institutional animal care and use purposes. Core A will also track study enrollment and provide a continuing review of enrollment to PIs to ensure overall patient recruitment goals and timelines are being met. The Core will continue to provide scientific coordination and interaction through structured monthly, quarterly, and yearly meetings, and will monitor project progress and assist PIs with annual progress reports. Oversight will additionally be provided by an established External Advisory Board of accomplished immunologists with extensive relevant expertise in B cell biology, tolerance, inflammation and epigenetics. Core A will facilitate interactions between PPG leadership and the External Advisory Board through planning and execution of a yearly meeting designed to provide project updates, discuss ongoing and future studies, and obtain objective feedback on the overall status of the program. The core will also ensure timely dissemination of results and data sharing though project presentation and publication targets. By streamlining and consolidating administrative task and providing strategic leadership and internal and external coordination, Core A will enable the project PIs to collaboratively produce rigorous and impactful scientific findings that increase our understanding of plasma cells and positively influence human health. 1