Administrative Core

行政核心A摘要。 通过强有力的行政结构进行协调的领导是联合国成功的一个重要组成部分， 复杂的多实验室项目。这对于涉及人类研究的项目尤其如此， 必须满足的其他招募、安全性和监管问题。核心A的目的是促进 PPG项目在了解浆细胞发育过程中的进展， 它在疾病中的失调。为达致这个目标，我们会继续兴建和改善基础设施 我们在过去5年中一直在开发用于PPG管理的方法。核心的功能 A将继续提供行政支助、组织、协调和有效管理 该PPG的总体目标是确保所有项目的科学生产力。 核心A将由Iñaki Sanz博士指导（总体P.I.，和项目4领导人），谁除了是一个世界 他是人类B细胞生物学的一流专家，也积累了指导多研究者的丰富经验 过去20年的研究项目。他将得到两名招聘的专家工作人员的协助;艾米博士 Stout在提供行政和财务支持以及监督多中心方面拥有丰富的经验 项目和桑乐女士谁拥有15年的经验，监督标本收集 计划和埃默里IRB系统内的大型临床试验。通过行政监督， 指导，我们将确保适当和及时的财政管理和有效利用人力和财力， 资源 核心A将确保所有工作人员和支持人员都接受过安全、机构 审查委员会，以及机构动物护理和使用目的。核心A还将跟踪研究入组情况， 向PI提供入组的持续审查，以确保总体患者招募目标和时间表 被满足。该核心将继续通过每月有组织的， 此外，还将监督项目进展情况，并协助PI编写年度进展报告。 此外，由资深免疫学家组成的外部咨询委员会将提供监督 在B细胞生物学、耐受性、炎症和表观遗传学方面具有广泛的相关专业知识。核心A将促进 PPG领导层和外部咨询委员会之间的互动，通过规划和执行一个 年度会议，旨在提供项目更新，讨论正在进行的和未来的研究，并获得目标 对项目整体状况的反馈。该核心还将确保及时传播成果和数据 通过项目介绍和出版目标进行分享。通过精简和合并行政 核心A将使项目PI 合作产生严谨和有影响力的科学发现，增加我们对血浆的理解 细胞和积极影响人类健康。 1

ADMINISTRATIVE CORE A ABSTRACT. Coordinated leadership through a strong administrative structure is an essential component of the success of complex multiple-laboratory projects. This is particularly true for projects involving human research as there are additional recruitment, safety, and regulatory concerns that must be met. The purpose of Core A is to facilitate progress of the projects of the PPG in understanding the processes that underly plasma cell development and its dysregulation in disease. To accomplish this objective, we will continue to build and refine the infrastructure that we have been developing over the previous 5 years for the administration of this PPG. The function of Core A will continue to be to provide administrative support, organization, coordination and efficient management of this PPG with the overarching goal of ensuring the scientific productivity of all projects. Core A will be directed by Dr. Iñaki Sanz (overall P.I., and Project 4 Leader), who in addition to being a world class expert on human B cell biology, has also accumulated substantial experience in directing multi-investigator research programs over the past 20 years. He will be assisted by two recruited expert staff members; Dr. Amy Stout who has extensive experience providing administrative and financial support and overseeing multi-center projects at Emory University and Ms. Sang Le who has 15 years experience overseeing specimen collection programs and enabling large clinical trials within the Emory IRB system. Through administrative oversight and guidance, we will ensure proper and timely fiscal management and efficient use of human and financial resources. Core A will make sure that all staff and support personnel are trained and accredited for safety, Institutional Review Board, and institutional animal care and use purposes. Core A will also track study enrollment and provide a continuing review of enrollment to PIs to ensure overall patient recruitment goals and timelines are being met. The Core will continue to provide scientific coordination and interaction through structured monthly, quarterly, and yearly meetings, and will monitor project progress and assist PIs with annual progress reports. Oversight will additionally be provided by an established External Advisory Board of accomplished immunologists with extensive relevant expertise in B cell biology, tolerance, inflammation and epigenetics. Core A will facilitate interactions between PPG leadership and the External Advisory Board through planning and execution of a yearly meeting designed to provide project updates, discuss ongoing and future studies, and obtain objective feedback on the overall status of the program. The core will also ensure timely dissemination of results and data sharing though project presentation and publication targets. By streamlining and consolidating administrative task and providing strategic leadership and internal and external coordination, Core A will enable the project PIs to collaboratively produce rigorous and impactful scientific findings that increase our understanding of plasma cells and positively influence human health. 1