Biostatistics Core

项目概要：生物统计学和生物信息学共享资源核心 在这项申请中，我们建议加强我们现有的梅哈里医学院/范德比尔特-英格拉姆的作用 癌症中心/田纳西州立大学癌症伙伴关系（MVTCP）生物信息学和生物统计学 共享资源核心（BBSRC）。BBSRC将支持两个完整项目和一个试点项目;详细和 为每个特定目标/子目标提供了特定的生物统计和生物信息学分析计划， 项目计算每个主要实验的样本量，以提供高功效来检测临床或 生物相关效应。对于具有高维数据分析的项目， 研究策略将用于评估数据质量，然后仅在以下情况下进行统计分析 预处理以解决质量问题。所有MVTCP研究都需要生物统计学家的BBSRC支持 和生物信息学家从这个核心分配到每个项目。BBSRC的工作人员一直在工作，并将继续 与项目负责人密切合作，确保生物统计学和生物信息学共享资源核心 为MVTCP提供最先进的统计/生物信息学支持。

PROJECT SUMMARY: BIOSTASTICS AND BIOINFORMATICS SHARED RESOURCE CORE In this application, we propose to intensify the role of our existing Meharry Medical College/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) Bioinformatics and Biostatistics Shared Resource Core (BBSRC). The BBSRC will support two full projects and one pilot project; detailed and specific biostatistical and bioinformatic analysis plans are provided for each specific aim/sub-aim within each project. Sample size for each primary experiment is computed to provide high power to detect clinically or biologically relevant effects. For projects with high-dimensional data analyses, the methods described in the Research Strategy will be applied to assess data quality and then perform statistical analysis only after preprocessing to address quality issues. BBSRC support is required for all MVTCP studies, with biostatisticians and bioinformaticians from this core assigned to each project. BBSRC personnel have worked and will continue to work closely with project leaders to ensure the Biostatistics and Bioinformatics Shared Resource Core provides state-of-the-art statistical/bioinformatic support to the MVTCP.