Biostatistics and Bioinformatics Shared Resource

生物统计学和生物信息学共享资源

• 批准号: 10595758
• 负责人: Jeffrey M. Switchenko
• 金额: $ 19.87万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-07 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10595758
• 关键词: Address; Attention; Awareness; Basic Science; Big Data; Bioinformatics; Bioinformatics Shared Resource; Biological Markers; Biometry; Cancer Center Support Grant; Clinical; Clinical Data; Clinical Protocols; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Collaborations; Consultations; Data; Data Analyses; Databases; Educational workshop; Ensure; Faculty; Funding; Goals; Grant; Head and Neck Cancer; Institutes; Investigation; Journals; Knowledge; Laboratories; Leadership; Malignant Neoplasms; Malignant neoplasm of lung; Manuscripts; Methodology; Methods; Mission; Molecular; Monitor; Observational Study; Pathway Analysis; Peer Review Grants; Phase I Clinical Trials; Play; Population; Population Sciences; Population Study; Positioning Attribute; Preparation; Protocols documentation; Public Health Schools; Publications; Quality Control; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Retrospective Studies; Role; Safety; Sample Size; Science; Services; Site; Statistical Data Interpretation; Statistical Methods; Summary Reports; System; Time; Training; Translating; Translational Research; Universities; analytical method; anticancer research; base; biomarker discovery; career; clinical application; data management; data quality; design; improved; meeting abstracts; member; mindfulness; novel; novel anticancer drug; phase 1 study; preclinical study; programs; surveillance data; translational study; trial design; user-friendly

BIOSTATISTICAL AND BIOINFORMATICS SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Winship Biostatistics and Bioinformatics Shared Resource (BBISR) offers services and collaboration in clinical, laboratory, population, and molecular cancer study design and analysis. BBISR is defined by a TEAMbased approach to support cancer investigators, in which BBISR faculty and staff are Thoughtfully Engaged to obtain Accurate results, while being Mindfully aware of their role in this cancer research and the deadlines for their execution. The overall goal of BBISR is to provide outstanding statistical and analytical support to Winship’s basic, translational, and clinical research. This is accomplished by ensuring the use of appropriate study design and analytical methods by Winship members for their research projects. BBISR has established a user-friendly online service request system that allows for timely support and tracking of SR utilization, and leverages existing Emory University-wide expertise to meet Winship member needs. It supports Winship researchers specifically by: designing trials with attention to feasibility, sample size, and biomarker analysis; data analysis and preparation of study summary reports; assistance with manuscript preparation for sections relevant to statistical design and methods; and review of proposals in Winship’s Clinical and Translational Research Committee (CTRC). BBISR staff members are integrated within Winship’s research programs and throughout Emory University, including the Rollins School of Public Health. BBISR staff and faculty members have strong expertise in phase I clinical trial designs, retrospective study designs and analysis, clinical bioinformatics, pathways and network analysis, fusion analysis, and analysis of “Big Data” in the form of both molecular and cancer surveillance data. BBISR has supported several high-impact publications and played key roles in all the team-science projects that have been conducted at Winship during this funding period. BBISR supported Winship team science projects including the Head and Neck Cancer SPORE, a program project application for lung cancer (resubmission in September 2016), a developing Lung Cancer SPORE application (to be submitted in September 2016), and institutional clinical trials, including phase I studies. In addition, original research conducted by BBISR members have resulted in important methodological advances in the design and conduct of phase I clinical trials. Overall, BBISR supported 115 core investigators in Winship programs during this funding period, collaborations which have resulted in 216 publications and 50 peer-reviewed grants funded. Utilization of BBISR has grown steadily over the present funding period by membership of all four Winship programs and BBISR is well positioned to support Winship’s ongoing and planned research projects.

生物统计和生物信息学共享资源 项目概要/摘要 Winship 生物统计和生物信息学共享资源 (BBISR) 提供以下方面的服务和协作： 临床、实验室、人群和分子癌症研究设计和分析。 BBISR 是通过基于团队的方法来支持癌症研究人员的，其中 BBISR 教职员工深思熟虑地参与 获得准确的结果，同时注意他们在这项癌症研究中的作用以及最后期限 他们的处决。 BBISR 的总体目标是为 Winship 提供出色的统计和分析支持 基础、转化和临床研究。这是通过确保使用适当的研究设计来实现的 以及 Winship 成员对其研究项目的分析方法。 BBISR 建立了一个用户友好的 在线服务请求系统，可以及时支持和跟踪 SR 利用率，并利用现有的 埃默里大学的专业知识可满足 Winship 会员的需求。它专门支持Winship研究人员 通过：设计试验时注意可行性、样本量和生物标志物分析；数据分析和 准备研究总结报告；协助准备与统计相关的部分的稿件 设计和方法；并审查 Winship 临床和转化研究委员会的提案 （CTRC）。 BBISR 工作人员融入 Winship 的研究项目和整个埃默里大学 大学，包括罗林斯公共卫生学院。 BBISR 员工和教职人员拥有丰富的专业知识 I 期临床试验设计、回顾性研究设计和分析、临床生物信息学、路径和 分子和癌症监测形式的网络分析、融合分析和“大数据”分析 数据。 BBISR 支持了几份高影响力的出版物，并在所有团队科学项目中发挥了关键作用 在此资助期间，Winship 进行了这些研究。 BBISR 支持 Winship 团队科学项目 包括头颈癌 SPORE，一项针对肺癌的计划项目申请（于 2019 年重新提交） 2016 年 9 月），正在开发的肺癌 SPORE 申请（将于 2016 年 9 月提交），以及 机构临床试验，包括 I 期研究。此外，BBISR 成员进行的原创研究 在 I 期临床试验的设计和实施方面取得了重要的方法学进展。全面的， BBISR 在此资助期间为 Winship 项目的 115 名核心研究人员提供了支持，合作 已发表 216 篇出版物并获得 50 项同行评审资助。 BBISR 的利用率稳步增长 在目前的资助期内，所有四个 Winship 计划的成员都获得了资金，BBISR 处于有利地位 支持 Winship 正在进行和计划中的研究项目。