MEDICINAL CHEMISTRY CONSULTING SERVICES FOR NINDS' HEAL PROGRAM

承包商应为NINDS提供以下咨询支持服务： 药物化学 预计药物化学顾问将提供高级药物化学专业知识，并通过电话会议和电子邮件向NIH和LDT成员提供关于项目的反馈和指导。药物化学顾问的作用可包括但不限于以下职责和任务： ·提供有关项目里程碑、目标产品简介和测试漏斗的意见 ·就化学服务承包商为每一轮搜救提出的化学结构和工艺提供反馈 ·每周或每两周评估一次搜救数据。 ·药物化学顾问可能被要求评估药物化学化学结构的潜在可处理性(包括周围的IP空间)。具体的咨询责任将取决于个别顾问的专业知识和个别项目的需要。 ·与其他顾问、承包商和NIH工作人员合作，为药物化学项目提供建议、战略规划和管理，以促进探索性化学、Hit-to-Lead、Lead优化、IND支持和临床研究。 ·担任药物化学专家，以确定潜在的药物发现和开发挑战，并提出应对这些挑战的战略。 ·合作设计调查性研究，以支持国立卫生研究院的药物发现和开发项目。 ·陪同NIH工作人员或应NIH工作人员要求访问NINDS合同下的合同研究组织[CRO]。检查设施并讨论CRO提出的方法的适当性。向NINDS员工提交旅行报告。 ·通过电话和电子邮件促进Lead开发团队就指定的药物代谢和药代动力学工作进行讨论。 这项研究是NIH帮助结束成瘾长期(Hear)倡议的一部分，该倡议旨在加快科学解决方案，以了解疼痛的基础并加强临床疼痛管理。这是该计划的一部分，该计划为各种疼痛状况建立了新的治疗选择，以提高生活质量和减少阿片类药物依赖。该项目研究范围广泛的疼痛状况，包括慢性重叠疼痛状况、慢性肌肉骨骼疼痛、围手术期疼痛和膝骨性关节炎。

The Contractor shall provide consulting support services to the NINDS as follows: Medicinal Chemistry Medicinal chemistry consultants will be expected to provide senior-level medicinal chemistry expertise and contribute feedback and guidance on projects to the NIH and to LDT members through conference calls and by email. The role of the medicinal chemistry consultant may include but is not limited to the following responsibilities and tasks: • Offer input on project milestones, target product profiles, and testing funnels • Provide feedback on chemical structures and processes proposed by a chemistry service contractor for each round of SAR • Evaluate SAR data on a weekly or biweekly basis. • Medicinal chemistry consultant may be asked to evaluate the potential tractability (including surrounding IP space) of a chemical structure for medicinal chemistry. Specific consulting responsibilities will depend on the expertise of the individual consultant and the needs of individual projects. • In partnership with other consultants, contractors, and the NIH staff, advise, strategically plan, and manage medicinal chemistry programs to facilitate exploratory chemistry, hit-to-lead, lead optimization, IND enabling, and clinical studies. • Serve as the medicinal chemistry expert in order to identify potential drug discovery and development challenges and suggest strategies to address these challenges. • Collaborate on design of investigative studies in support of NIH drug discovery and development projects. • Accompany NIH staff or visit, at NIH staff request, Contract Research Organizations [CRO] under contract to NINDS. Inspect facilities and discuss appropriateness of CRO proposed methodology. Submit trip reports to NINDS staff. • Facilitate Lead Development Team discussions via telephone and email regarding assigned drug metabolism and pharmacokinetics efforts. This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management. It’s part of the program that establishes novel treatment options for a variety of pain conditions to improve quality of life and reduce opioid dependency. The program studies a broad range of pain conditions, including chronic overlapping pain conditions, chronic musculoskeletal pain, perioperative pain, and knee osteoarthritis.