SBIR TOPIC 415: Design and Construction of a Novel Electron Brachytherapy Source Driven by a Laser Plasma Accelerator
SBIR TOPIC 415: Design and Construction of a Novel Electron Brachytherapy Source Driven by a Laser Plasma Accelerator
批准号:
10496713
负责人:
STEVE GOURLAY
金额:
$39.98万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-09-16 至 2022-06-15
关键词:
Alpha ParticlesBrachytherapyCancer ControlDataDevelopmentDevicesDoseDose-RateElectron BeamElectronsExternal Beam Radiation TherapyFast NeutronsFiberFreedomGamma RaysHigh-Dose Rate BrachytherapyIsotopesLasersMedicalMiniaturizationOpticsPhysicsPhysiologic pulseProcessRadiation OncologyRadiation therapyRadioactiveRadioisotopesRoentgen RaysSmall Business Innovation Research GrantSourceStructureSystemTechnologyTherapeuticTimeTissuesTranslatingbasecancer sitecancer therapyclinical practiceclinically relevantdesigndesign and constructiondosimetryflexibilityimprovednoveloperationoptical fiberparticleplasma acceleratorprogramstime usetooltreatment optimizationtreatment planningtwo-photon
中文摘要
A.背景信息
英文摘要
A. Background Information
The long-term objective of this proposal is to advance the treatment of cancer using laser plasma
accelerator physics breakthroughs at LBNL to build a miniature electron accelerator as a variable Xrays
source with clinically relevant dose-rates of ~0.7 Gy/min and energies between 0.25 – 5 MeV.
This electronic particle brachytherapy source is powered by a commercial, laser system, operating up
to 1000 Hz and 7 W of average power. The flexibility of the laser driver allows treatment with
radioisotope-free operation and variable x-ray energy on a pulse-by-pulse basis. This confers extra
degrees of freedom for the treatment planning process thus providing the clinician the ability to
improve the dose delivery. Unwanted dose to nearby healthy tissue and critical structures is reduced.
This proposal brings a world-class team together: LBNL in laser plasma accelerators and optical
fiber-based delivery systems, Woodtoga to translate the technology into clinically relevant products
with expertise in bonding and the creation of miniature X-ray devices, and Varian Medical Systems as
the commercial partner. Integrating the technology with clinical practice, treatment planning, into a
radiation oncology platform transforming the field of brachytherapy.
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