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Evaluating the Impact of Restrictive Eating Disorders on White Matter Development

评估限制性饮食失调对脑白质发育的影响

基本信息

批准号：
10494893
负责人：
AMANDA ELLIS LYALL
金额：
$ 42万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10494893
关键词：
Adolescence Affect Age Anisotropy Anorexia Nervosa Anterior Blood Blood specimen Brain Brain region Career Mobility Cells Characteristics Childhood Clinical Clinical Research Consumption Control Groups Data Data Set Development Diagnostic Dietary Component Dietary Factors Dietary intake Dietitian Diffusion Magnetic Resonance Imaging Disease Eating Disorders Energy Intake Fatty Acids Fatty acid glycerol esters Female Food Foundations Future General Hospitals Glucose Goals Grant Health Human Image Individual Intervention Investigation Iron Knowledge Lead Life Link Location Macronutrients Nutrition Maintenance Malnutrition Massachusetts Measures Mental disorders Modeling Myelin National Institute of Mental Health Neurobiology Nutritional Oligodendroglia Omega-3 Fatty Acids Parents Patients Pattern Philadelphia Population Premature Mortality Prevention Principal Investigator Process Production Psychotic Disorders Records Reporting Research Research Personnel Research Project Grants Resources Sampling Site Staging Structure Techniques Testing Therapeutic Intervention Time Vitamin D Vitamin K Vitamins Water Work aged avoidant restrictive food intake disorder brain health clinical practice cohort connectome critical developmental period critical period data harmonization design dietary dietary restriction dietary supplements effectiveness testing emerging adult gray matter image processing imaging study improved in vivo individualized medicine interest knowledge base medical schools myelination neuroimaging novel prepuberty programs restrictive eating tool white matter young adult

项目摘要

Project Summary In this application for a Stephen I. Katz Early Investigator Research Project Grant, the principal investigator, Dr. Amanda E. Lyall, proposes a project that will support a new research direction for her career: the transition from the use of neuroimaging to study psychotic disorders to the investigation of restrictive eating disorders. The over- arching goal of this application is to comprehensively characterize the impact of restrictive eating disorders on white matter development. This study will leverage unique access to extant neuroimaging, clinical, blood, and dietary intake data collected under 4 parent NIMH grant mechanisms (R01MH103402; R01MH108595; R01MH116205; K23MH125143) at the Eating Disorders Clinical Research Program at Massachusetts General Hospital, Harvard Medical School. We will use our well-validated diffusion magnetic resonance imaging (dMRI) harmonization framework to combine these data with 2 publicly available dMRI datasets of healthy controls: The Philadelphia Neurodevelopmental Cohort and The Human Connectome Project – Young Adult, yielding a cohort of harmonized imaging data spanning the period of white matter development from ages 9 to 40 years. With these data, we will examine the trajectories of global and region-specific white matter development using advanced dMRI analysis tools between healthy controls and individuals with restrictive eating disorders (Aim 1). Next, we will determine the extent to which age or pubertal stage modifies the relationship between potential white matter alterations in individuals with restrictive eating disorders and the duration of dietary restriction (Aim 2). Finally, we will evaluate the extent to which total caloric and/or specific nutritional deficiencies that arise because of severe dietary restriction impact white matter development (Aim 3). We believe that the information generated within this proposal will provide a critical first step in developing a knowledge base about the impact of severe dietary restriction on brain development. This proposal will provide an opportunity to identify vulnerable periods where therapeutic interventions may be necessary or have the most impact. Additionally, the results of this study may also provide a foundation for future work to test the effectiveness and tolerability of novel applications of non-invasive individualized therapies centering on improving white matter health.

项目总结