Evaluating the Impact of Restrictive Eating Disorders on White Matter Development
评估限制性饮食失调对脑白质发育的影响
基本信息
- 批准号:10494893
- 负责人:
- 金额:$ 42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AdolescenceAffectAgeAnisotropyAnorexia NervosaAnteriorBloodBlood specimenBrainBrain regionCareer MobilityCellsCharacteristicsChildhoodClinicalClinical ResearchConsumptionControl GroupsDataData SetDevelopmentDiagnosticDietary ComponentDietary FactorsDietary intakeDietitianDiffusion Magnetic Resonance ImagingDiseaseEating DisordersEnergy IntakeFatty AcidsFatty acid glycerol estersFemaleFoodFoundationsFutureGeneral HospitalsGlucoseGoalsGrantHealthHumanImageIndividualInterventionInvestigationIronKnowledgeLeadLifeLinkLocationMacronutrients NutritionMaintenanceMalnutritionMassachusettsMeasuresMental disordersModelingMyelinNational Institute of Mental HealthNeurobiologyNutritionalOligodendrogliaOmega-3 Fatty AcidsParentsPatientsPatternPhiladelphiaPopulationPremature MortalityPreventionPrincipal InvestigatorProcessProductionPsychotic DisordersRecordsReportingResearchResearch PersonnelResearch Project GrantsResourcesSamplingSiteStagingStructureTechniquesTestingTherapeutic InterventionTimeVitamin DVitamin KVitaminsWaterWorkagedavoidant restrictive food intake disorderbrain healthclinical practicecohortconnectomecritical developmental periodcritical perioddata harmonizationdesigndietarydietary restrictiondietary supplementseffectiveness testingemerging adultgray matterimage processingimaging studyimprovedin vivoindividualized medicineinterestknowledge basemedical schoolsmyelinationneuroimagingnovelprepubertyprogramsrestrictive eatingtoolwhite matteryoung adult
项目摘要
Project Summary
In this application for a Stephen I. Katz Early Investigator Research Project Grant, the principal investigator, Dr.
Amanda E. Lyall, proposes a project that will support a new research direction for her career: the transition from
the use of neuroimaging to study psychotic disorders to the investigation of restrictive eating disorders. The over-
arching goal of this application is to comprehensively characterize the impact of restrictive eating disorders on
white matter development. This study will leverage unique access to extant neuroimaging, clinical, blood, and
dietary intake data collected under 4 parent NIMH grant mechanisms (R01MH103402; R01MH108595;
R01MH116205; K23MH125143) at the Eating Disorders Clinical Research Program at Massachusetts General
Hospital, Harvard Medical School. We will use our well-validated diffusion magnetic resonance imaging (dMRI)
harmonization framework to combine these data with 2 publicly available dMRI datasets of healthy controls: The
Philadelphia Neurodevelopmental Cohort and The Human Connectome Project – Young Adult, yielding a cohort
of harmonized imaging data spanning the period of white matter development from ages 9 to 40 years. With
these data, we will examine the trajectories of global and region-specific white matter development using
advanced dMRI analysis tools between healthy controls and individuals with restrictive eating disorders (Aim 1).
Next, we will determine the extent to which age or pubertal stage modifies the relationship between potential
white matter alterations in individuals with restrictive eating disorders and the duration of dietary restriction (Aim
2). Finally, we will evaluate the extent to which total caloric and/or specific nutritional deficiencies that arise
because of severe dietary restriction impact white matter development (Aim 3). We believe that the information
generated within this proposal will provide a critical first step in developing a knowledge base about the impact
of severe dietary restriction on brain development. This proposal will provide an opportunity to identify vulnerable
periods where therapeutic interventions may be necessary or have the most impact. Additionally, the results of
this study may also provide a foundation for future work to test the effectiveness and tolerability of novel
applications of non-invasive individualized therapies centering on improving white matter health.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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AMANDA ELLIS LYALL其他文献
AMANDA ELLIS LYALL的其他文献
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{{ truncateString('AMANDA ELLIS LYALL', 18)}}的其他基金
Neuroimaging of the Biological Correlates of Early Psychosis: A MR-PET Study
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- 批准号:
10002036 - 财政年份:2018
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$ 42万 - 项目类别:
Neuroimaging of the Biological Correlates of Early Psychosis: A MR-PET Study
早期精神病生物学相关性的神经影像学:MR-PET 研究
- 批准号:
10224843 - 财政年份:2018
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Neuroimaging of the Biological Correlates of Early Psychosis: A MR-PET Study
早期精神病生物学相关性的神经影像学:MR-PET 研究
- 批准号:
9751969 - 财政年份:2018
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Neuroimaging of the Biological Correlates of Early Psychosis: A MR-PET Study
早期精神病生物学相关性的神经影像学:MR-PET 研究
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10460419 - 财政年份:2018
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- 批准号:
9331746 - 财政年份:2016
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