Healthy Brain and Child Development National Consortium Data Coordinating Center

项目总结 具有里程碑意义的健康大脑和儿童发展(HBCD)研究将提供具有代表性的参考数据 为科学界提供资源，使人们能够对神经发育及其影响进行前所未有的研究 环境、遗传和生物因素对大脑和行为健康以及发育轨迹的影响 从婴儿期到儿童期。通过这项研究，健康的大脑和儿童发展国家 联合会(HBCD-NC)将招募和保留7500名孕妇的社会人口学多样性队列 来自美国各地的24个地点，跟踪这些家庭和他们的孩子度过生命的第一个十年。儿童 将接受严格的数据收集，包括神经成像、神经生理学、行为和 认知评估，并通过由领域领先的开发的平衡方案收集生物标本 专家。以其多学科团队的实质性互补经验和专门知识为基础， 利用多种针对特定人群的技术创新，健康大脑和儿童发展国家 联盟数据协调中心(HDCC)将提供对数据的领导、管理和监督 收集、质量控制、管理、处理、管理、共享和分析，以促进和支持 我们将继续支持HBCD-NC的各项活动，并确保其成功。其中包括开发和实施一个优化的、 最先进的磁共振成像方案首次在所有三家主要供应商的婴儿/幼儿身上进行了协调 利用扫描仪技术的最新创新，具有特定年龄的结构、微观结构、定量 功能和光谱序列。还详细介绍了一种定向脑电协议，该协议与领域领先的 用于发育性脑电的自动化处理流水线，提供创新的衍生措施。数据和 项目管理将通过一个集中的跟踪和分发平台链接到一个高吞吐量 克服商用管理和集成系统的限制的计算主干 处理来自大型、多站点研究的多模式数据。将支持高性能计算 通过独一无二地访问领域领先资源的组合。详细程序概述，以确保 收集、管理和分析个人身份信息(PII)数据，包括灵活的方法 旨在适应跨站点的电子健康记录系统的异构性。最后，实质性的 HBCD对数据探索和分析门户(DEAP 2.0)的特定增强将产生一个关键工具 向经过认证的用户提供数据访问，同时促进可重复统计分析的最佳做法 提供灵活的计算，而无需下载受限访问数据。这一领域的结果是- HDCC资源的领先组合将是规模无与伦比的最先进的纵向数据集 它提供了对影响儿童健康的生物和环境因素的深刻理解， 以及行为发展，并塑造未来几十年的研究、临床护理和公共政策。

PROJECT SUMMARY The landmark Healthy Brain and Child Development (HBCD) study will provide a representative reference data resource to the scientific community enabling unprecedented investigation of neurodevelopment and the impact of environmental, genetic, and biological factors on brain and behavioral health and developmental trajectories from infancy through childhood. Through this study, the Healthy Brain and Child Development National Consortium (HBCD-NC) will recruit and retain a sociodemographically diverse cohort of 7,500 pregnant women from 24 sites across the U.S. and follow these families and their children through the first decade of life. Children will undergo rigorous data collection across modalities including neuroimaging, neurophysiology, behavioral and cognitive assessments, and collection of biospecimens via a balanced protocol developed by field-leading experts. Building upon the substantive complementary experience and expertise of its multidisciplinary team and leveraging multiple population-specific technical innovations, the Healthy Brain and Child Development National Consortium Data Coordinating Center (HDCC) will provide the leadership, management, and oversight of data collection, quality control, curation, processing, management, sharing, and analytics to facilitate and support the activities of the HBCD-NC and ensure its success. Included is development and implementation of an optimized, state-of-the-art MRI protocol harmonized for the first time in infants/toddlers across all three major vendors which leverages the latest innovations in scanner technology with age-specific structural, microstructural, quantitative, functional, and spectroscopy sequences. Also detailed is a targeted EEG protocol linked with a field-leading automated processing pipeline for developmental EEG which provides innovative derivative measures. Data and project management will occur through a centralized tracking and distribution platform linked to a high-throughput compute backbone which overcomes limits of commercially-available systems for management and integrated processing of multimodality data from large, multi-site studies. High performance computing will be supported through unique access to a combination of field-leading resources. Detailed procedures are outlined for secure collection, management, and analysis of personally identifiable information (PII) data, including flexible methods designed to accommodate heterogeneity in electronic health record systems across sites. Finally, substantive HBCD-specific enhancements to the Data Exploration and Analysis Portal (DEAP 2.0) will produce a crucial tool for data access to authenticated users while promoting best practices in reproducible statistical analysis and providing flexible computation without the need to download restricted-access data. The result of this field- leading combination of HDCC resources will be a state-of-the-art, longitudinal data set of unparalleled scale which provides deep understanding of the biological and environmental factors that affect a child’s health, brain, and behavioral development and shapes research, clinical care, and public policy for decades to come.