Healthy Brain and Child Development National Consortium Data Coordinating Center

项目摘要 具有里程碑意义的健康大脑和儿童发育（HBCD）研究将提供代表性的参考数据 科学界的资源，使前所未有的调查神经发育和影响 环境，遗传和生物因素对大脑和行为健康和发育轨迹的影响 从婴儿期到童年。通过这项研究，健康的大脑和儿童发展国家 六溴环十二烷-NC联合会将招募和保留一个由7，500名孕妇组成的社会人口统计学上多样化的队列 来自美国24个地点，跟踪这些家庭和他们的孩子度过生命的第一个十年。儿童 将接受严格的数据收集，包括神经影像学，神经生理学，行为和 认知评估和生物标本的收集通过一个平衡的协议开发的领域领先的 专家利用其多学科小组的实质性互补经验和专门知识， 利用多种针对特定人群的技术创新，健康大脑和儿童发展国家计划 联盟数据协调中心（HDCC）将提供数据的领导、管理和监督 收集，质量控制，策展，处理，管理，共享和分析，以促进和支持 六溴环十二烷国家中心的活动，并确保其成功。包括开发和实施一个优化的， 最先进的MRI方案首次在所有三家主要供应商的婴儿/幼儿中协调一致， 利用扫描仪技术的最新创新，具有特定年龄的结构，微观结构，定量， 功能和光谱序列。还详细介绍了一个有针对性的脑电图协议与一个领域领先的 开发EEG的自动化处理管道，提供创新的衍生措施。数据和 项目管理将通过一个与高吞吐量网络连接的集中跟踪和分发平台进行， 计算骨干网，它克服了商业上可用的系统的限制， 处理来自大型多中心研究的多模态数据。将支持高性能计算 通过独特的方式访问现场领先的资源组合。详细的程序概述了安全 收集、管理和分析个人身份信息（PII）数据，包括灵活的方法 旨在适应不同站点的电子健康记录系统的异质性。最后，实质性 针对六溴环十二烷的数据探索和分析门户网站（DEAP 2.0）的增强将产生一个关键工具 向经过认证的用户提供数据访问，同时推广可重复统计分析方面的最佳做法， 提供灵活的计算而无需下载受限访问数据。这个领域的结果- HDCC资源的领先组合将是一个最先进的、规模无与伦比的纵向数据集 它提供了对影响儿童健康，大脑， 和行为发展，并在未来几十年内塑造研究，临床护理和公共政策。

PROJECT SUMMARY The landmark Healthy Brain and Child Development (HBCD) study will provide a representative reference data resource to the scientific community enabling unprecedented investigation of neurodevelopment and the impact of environmental, genetic, and biological factors on brain and behavioral health and developmental trajectories from infancy through childhood. Through this study, the Healthy Brain and Child Development National Consortium (HBCD-NC) will recruit and retain a sociodemographically diverse cohort of 7,500 pregnant women from 24 sites across the U.S. and follow these families and their children through the first decade of life. Children will undergo rigorous data collection across modalities including neuroimaging, neurophysiology, behavioral and cognitive assessments, and collection of biospecimens via a balanced protocol developed by field-leading experts. Building upon the substantive complementary experience and expertise of its multidisciplinary team and leveraging multiple population-specific technical innovations, the Healthy Brain and Child Development National Consortium Data Coordinating Center (HDCC) will provide the leadership, management, and oversight of data collection, quality control, curation, processing, management, sharing, and analytics to facilitate and support the activities of the HBCD-NC and ensure its success. Included is development and implementation of an optimized, state-of-the-art MRI protocol harmonized for the first time in infants/toddlers across all three major vendors which leverages the latest innovations in scanner technology with age-specific structural, microstructural, quantitative, functional, and spectroscopy sequences. Also detailed is a targeted EEG protocol linked with a field-leading automated processing pipeline for developmental EEG which provides innovative derivative measures. Data and project management will occur through a centralized tracking and distribution platform linked to a high-throughput compute backbone which overcomes limits of commercially-available systems for management and integrated processing of multimodality data from large, multi-site studies. High performance computing will be supported through unique access to a combination of field-leading resources. Detailed procedures are outlined for secure collection, management, and analysis of personally identifiable information (PII) data, including flexible methods designed to accommodate heterogeneity in electronic health record systems across sites. Finally, substantive HBCD-specific enhancements to the Data Exploration and Analysis Portal (DEAP 2.0) will produce a crucial tool for data access to authenticated users while promoting best practices in reproducible statistical analysis and providing flexible computation without the need to download restricted-access data. The result of this field- leading combination of HDCC resources will be a state-of-the-art, longitudinal data set of unparalleled scale which provides deep understanding of the biological and environmental factors that affect a child’s health, brain, and behavioral development and shapes research, clinical care, and public policy for decades to come.