ARISTOTELES - Applying ARtificial Intelligence to Define clinical trajectorieS for personalized predicTiOn and early deTEctiOn of comorbidiTy and muLtimorbidiTy pattErnS
亚里士多德 - 应用人工智能定义临床轨迹,以实现个性化预测以及合并症和多发病模式的早期检测
基本信息
- 批准号:10103153
- 负责人:
- 金额:$ 20.37万
- 依托单位:
- 依托单位国家:英国
- 项目类别:EU-Funded
- 财政年份:2023
- 资助国家:英国
- 起止时间:2023 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The ARISTOTELES project aimsto build a multinational harmonized data platform to develop and implement novel artificial intelligence (AI) approaches for management of complex diseases, where progression and manifestations of comorbidities are via multiple interacting pathways. We aim to apply our novel approach to a population of great need due to atrial fibrillation (AF), but our outputs can be extended to other complex diseases with multimorbidity. By integrating AIs into clinical practice, our platform will form a backbone for acceptable, responsible, and respectful uses of patient/participant data to develop and validate novel trustworthy AI tools for morepersonalized risk assessment and management. This represents a paradigm shift in AF treatment, moving from a focus on individual risk factors and selected outcomes (eg. stroke) to a holistic approach, underpinning timely diagnostic and therapeutic interventions to reduce disease progression, disability, hospitalizations and mortality, as well as improve patient adherence to lifestyle modifications, medications, and other treatment regimens. ARISTOTELES will be delivered through 8 inter-linking work-packages (WPs): WP1 is study management/coordination. WP2 provides the ethical/legal requirements for the development of a trustworthy AI. WP3 addressesstakeholder understanding of AI, needs assessment, and engagement in all the phases of the AI development. In WP4, granular data on genotype and phenotype characteristics, are harmonized from different datasets into a common platform. In WP5, AI algorithms/tools are developed and connected to an interactive output interface for patients and clinicians. In WP6, we test the AI tool developed in WP5 in a clinical trial simulation (in silico trial). In WP7 a multicenter randomized trial runs across multiple countries including both primary care and secondary care. WP7 and WP8 drive the clinical implementation and dissemination of results.
ARISTOTELES项目旨在建立一个多国协调数据平台,以开发和实施用于复杂疾病管理的新型人工智能(AI)方法,其中合并症的进展和表现是通过多种相互作用的途径进行的。我们的目标是将我们的新方法应用于因房颤(AF)而有巨大需求的人群,但我们的输出可以扩展到其他复杂的疾病。通过将人工智能集成到临床实践中,我们的平台将形成一个可接受的,负责任的和尊重的使用患者/参与者数据的支柱,以开发和验证新颖的值得信赖的人工智能工具,用于更个性化的风险评估和管理。这代表了AF治疗的范式转变,从关注个体风险因素和选定结局(例如,中风)的治疗方法,支持及时的诊断和治疗干预,以减少疾病进展、残疾、住院和死亡,以及提高患者对生活方式改变、药物和其他治疗方案的依从性。ARISTOTELES将通过8个相互关联的工作包(WP)交付:WP 1是研究管理/协调。WP 2为开发可信赖的AI提供了道德/法律的要求。WP 3解决了利益相关者对AI的理解,需求评估以及参与AI开发的所有阶段。在WP 4中,关于基因型和表型特征的粒度数据从不同的数据集统一到一个通用平台中。在WP 5中,开发了AI算法/工具,并将其连接到患者和临床医生的交互式输出界面。在WP 6中,我们在临床试验模拟(计算机模拟试验)中测试了WP 5中开发的AI工具。在WP 7中,一项多中心随机试验在多个国家进行,包括初级保健和二级保健。WP7和WP8推动临床实施和结果传播。
项目成果
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其他文献
Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
- DOI:
10.1002/cam4.5377 - 发表时间:
2023-03 - 期刊:
- 影响因子:4
- 作者:
- 通讯作者:
Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
在自我监管的环境中,儿童和青少年在电视上接触不健康食品和饮料广告的情况存在差异。
- DOI:
10.1186/s12889-023-15027-w - 发表时间:
2023-03-23 - 期刊:
- 影响因子:4.5
- 作者:
- 通讯作者:
The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
类风湿性关节炎与估计心肺健康降低之间的关联是由身体症状和负面情绪介导的:一项横断面研究。
- DOI:
10.1007/s10067-023-06584-x - 发表时间:
2023-07 - 期刊:
- 影响因子:3.4
- 作者:
- 通讯作者:
ElasticBLAST: accelerating sequence search via cloud computing.
ElasticBLAST:通过云计算加速序列搜索。
- DOI:
10.1186/s12859-023-05245-9 - 发表时间:
2023-03-26 - 期刊:
- 影响因子:3
- 作者:
- 通讯作者:
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
使用通过嵌段共聚物自组装制造的 2D 金纳米结构阵列放大 EQCM-D 检测细胞外囊泡。
- DOI:
10.1039/d2nh00424k - 发表时间:
2023-03-27 - 期刊:
- 影响因子:9.7
- 作者:
- 通讯作者:
的其他文献
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{{ truncateString('', 18)}}的其他基金
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2901954 - 财政年份:2028
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Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
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2896097 - 财政年份:2027
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可以在颗粒材料中游动的机器人
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2780268 - 财政年份:2027
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$ 20.37万 - 项目类别:
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Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
- 批准号:
2908918 - 财政年份:2027
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Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
- 批准号:
2908693 - 财政年份:2027
- 资助金额:
$ 20.37万 - 项目类别:
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Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
- 批准号:
2908917 - 财政年份:2027
- 资助金额:
$ 20.37万 - 项目类别:
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Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
- 批准号:
2879438 - 财政年份:2027
- 资助金额:
$ 20.37万 - 项目类别:
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Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
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2890513 - 财政年份:2027
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CDT year 1 so TBC in Oct 2024
CDT 第 1 年,预计 2024 年 10 月
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Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
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