A Chemo-Mimetic Platform to Reprogram Metalloenzymes for Non-Natural Biocatalytic C-H Functionalization Reactions
用于非天然生物催化 C-H 功能化反应的金属酶重编程化学模拟平台
基本信息
- 批准号:10501566
- 负责人:
- 金额:$ 30.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:AnabolismBiochemicalBiochemistryBiologicalBiologyCatalysisChemicalsCollectionComputer ModelsDevelopmentEnzymesEvolutionGeneticHydrogen BondingKnowledgeMethodsMolecularOrganic SynthesisProcessProtein EngineeringProteinsReactionResearchSystemcatalystchemical synthesisdrug developmentdrug discoverydrug synthesisfunctional groupmetalloenzymemethod developmentmimeticsnovel therapeuticssmall moleculetool
项目摘要
Abstract/Summary
The development of methods for molecule construction and functionalization has expedited the drug
development process during the past decades. To this end, enzymatic C–H functionalization represents a
powerful approach to enable rapid molecular construction. Harnessing the ubiquitous C–H bonds in organic
molecules and genetic tunability of protein catalysts, enzymatic C–H functionalization provides sustainable
strategies to effect chemical transformations with high selectivity and efficiency. Despite significant advances,
the reaction scope of current enzymatic C–H functionalization is restricted to chemical reactivities acquired
through natural evolution. This limitation hampers the applications of enzymes for drug development as many
medicinally important chemical motifs are rarely present or even completely absent in biology. To expand the
chemical space of biosynthesis, we herein aim to develop new biocatalytic systems by repurposing
metalloenzymes for C–H functionalization reactions currently not present in biology. By integrating protein
engineering, computational modeling, organic synthesis, and biochemical and inorganic spectroscopic
analysis, we will create collections of metalloenzyme catalysts that can directly functionalize inert C(sp3)–H
bonds to install biomedically relevant chemical moieties. We envision that the enzymes we create will not
only provide powerful genetically encoded tools for numerous synthetic and biological applications, but will
also offer a fertile ground to enrich our fundamental knowledge of biochemistry and enzymatic catalysis
抽象/总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Xiongyi Huang', 18)}}的其他基金
A Chemo-Mimetic Platform to Reprogram Metalloenzymes for Non-Natural Biocatalytic C-H Functionalization Reactions
用于非天然生物催化 C-H 功能化反应的金属酶重编程化学模拟平台
- 批准号:
10661833 - 财政年份:2022
- 资助金额:
$ 30.96万 - 项目类别:
Expanding the chemistry of life: New enzymatic platforms for synthesis of bioactive organofluorines
扩展生命的化学:用于合成生物活性有机氟的新酶平台
- 批准号:
9751918 - 财政年份:2018
- 资助金额:
$ 30.96万 - 项目类别:
Expanding the chemistry of life: New enzymatic platforms for synthesis of bioactive organofluorines
扩展生命化学:用于合成生物活性有机氟的新酶平台
- 批准号:
10308388 - 财政年份:2018
- 资助金额:
$ 30.96万 - 项目类别:
Expanding the chemistry of life: New enzymatic platforms for synthesis of bioactive organofluorines
扩展生命化学:用于合成生物活性有机氟的新酶平台
- 批准号:
10044755 - 财政年份:2018
- 资助金额:
$ 30.96万 - 项目类别:
Expanding the chemistry of life: New enzymatic platforms for synthesis of bioactive organofluorines
扩展生命化学:用于合成生物活性有机氟的新酶平台
- 批准号:
10065508 - 财政年份:2018
- 资助金额:
$ 30.96万 - 项目类别:
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