Development of B cell memory in allergic asthma

过敏性哮喘中 B 细胞记忆的发展

基本信息

  • 批准号:
    10503760
  • 负责人:
  • 金额:
    $ 45.43万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-06-15 至 2026-04-30
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract Allergic asthma is a chronic inflammatory disease of the lungs without cure. Repetitive allergen exposure in the airway leads to the generation of pathogenic immune memory and the excessive production of allergen specific IgE antibodies that mediate inflammation, airway constriction and respiratory distress in patients with allergic asthma. Memory B cells are a key component of immune memory. The phenotypic and functional heterogeneity of MBCs affords their differential antibody responses as well as impact their trafficking, tissue retention and ability to disseminate systemically. In a mouse model of allergic lung inflammation, we have observed stable lung- localized MBCs and evidence for the generation of pathogenic antibody responses in sensitized lungs. We hypothesize that after local antigen sensitization, the lung acquires immune functions reminiscent of those in secondary lymphoid tissues, capable of maintaining long-lived memory B cells as well as generating new MBCs that can recirculate and disseminate in other tissues to mediate systemic allergic inflammation. In this study, we will 1) probe the development of memory B cells (MBCs) in allergic lungs including in-depth characterization of the critical MBC subset that contributes to allergen specific IgE response, and 2) how these MBCs disseminate systemically. We will also 3) explore strategies to intercept the systemic dissemination of pathogenic MBCs to halt the progression of allergic inflammation. These studies will advance our fundamental understanding of memory B cells as well as help devise new therapeutic strategies for allergic asthma.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Yee Ling Wu其他文献

Molecular basis of complement C1r deficiency in a male African American patient with systemic lupus erythematosus
  • DOI:
    10.1016/j.molimm.2010.05.072
  • 发表时间:
    2010-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Yee Ling Wu;Blake Brookshire;Chack-Yung Yu;Frank Arnett
  • 通讯作者:
    Frank Arnett
Low gene copy-number of complement C4A, the presence of HLA-DR3, and the presence of HLA-DR2 are independent and additive risk factors for human systemic lupus erythematosus
  • DOI:
    10.1016/j.molimm.2010.05.259
  • 发表时间:
    2010-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Yee Ling Wu;Emeli Lundstrom;Chau-Ching Liu;Yan Yang;Iva Gunnarsson;Elisabet Svenungsson;Bi Zhou;Karla N. Jones;Haikady N. Nagaraja;Gloria C. Higgins;Charles Spencer;Hermine Brunner;Dan J. Birmingham;Brad H. Rovin;Betty P. Tsao;Joseph M. Ahearn;Lee A. Hebert;Leonid Padyukov;C. Yung Yu
  • 通讯作者:
    C. Yung Yu
Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract
肺驻留记忆 B 细胞维持呼吸道中的过敏性 IgE 反应
  • DOI:
    10.1016/j.immuni.2025.03.001
  • 发表时间:
    2025-04-08
  • 期刊:
  • 影响因子:
    26.300
  • 作者:
    Alexander J. Nelson;Bruna K. Tatematsu;Jordan R. Beach;Dorothy K. Sojka;Yee Ling Wu
  • 通讯作者:
    Yee Ling Wu

Yee Ling Wu的其他文献

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{{ truncateString('Yee Ling Wu', 18)}}的其他基金

Development of B cell memory in allergic asthma
过敏性哮喘中 B 细胞记忆的发展
  • 批准号:
    10642902
  • 财政年份:
    2022
  • 资助金额:
    $ 45.43万
  • 项目类别:
Investigation of memory B cell response in asthmatic lungs.
哮喘肺部记忆 B 细胞反应的研究。
  • 批准号:
    10413232
  • 财政年份:
    2021
  • 资助金额:
    $ 45.43万
  • 项目类别:
Investigation of memory B cell response in asthmatic lungs.
哮喘肺部记忆 B 细胞反应的研究。
  • 批准号:
    10303811
  • 财政年份:
    2021
  • 资助金额:
    $ 45.43万
  • 项目类别:
Studies of Antibody Diversity and Genome Stability: Regulation of Activation-Indu
抗体多样性和基因组稳定性的研究:激活诱导的调节
  • 批准号:
    8591624
  • 财政年份:
    2010
  • 资助金额:
    $ 45.43万
  • 项目类别:
Studies of Antibody Diversity and Genome Stability: Regulation of Activation-Indu
抗体多样性和基因组稳定性的研究:激活诱导的调节
  • 批准号:
    8002358
  • 财政年份:
    2010
  • 资助金额:
    $ 45.43万
  • 项目类别:
Studies of Antibody Diversity and Genome Stability: Regulation of Activation-Indu
抗体多样性和基因组稳定性的研究:激活诱导的调节
  • 批准号:
    8374091
  • 财政年份:
    2010
  • 资助金额:
    $ 45.43万
  • 项目类别:
Studies of Antibody Diversity and Genome Stability: Regulation of Activation-Indu
抗体多样性和基因组稳定性的研究:激活诱导的调节
  • 批准号:
    8125086
  • 财政年份:
    2010
  • 资助金额:
    $ 45.43万
  • 项目类别:
Studies of Antibody Diversity and Genome Stability: Regulation of Activation-Indu
抗体多样性和基因组稳定性的研究:激活诱导的调节
  • 批准号:
    8409854
  • 财政年份:
    2010
  • 资助金额:
    $ 45.43万
  • 项目类别:
Studies of Antibody Diversity and Genome Stability: Regulation of Activation-Indu
抗体多样性和基因组稳定性的研究:激活诱导的调节
  • 批准号:
    8128051
  • 财政年份:
    2010
  • 资助金额:
    $ 45.43万
  • 项目类别:

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