Biostatistics, Epidemiology, and Research Design Core

生物统计、流行病学和研究设计(BERD)核心的目标是支持NNE-CTR核心 和研究人员在适当使用方法学和计算密集型方法以及 为他们的研究提供技术支持。自NNE-CTR获得资金以来的四年多时间里，BERD核心已经 投入大量资源和人员来建设我们的计算和数据基础设施， 支持和促进生物医学研究人员之间的合作研究的主要目标是 新英格兰北部的机构。我们的成功使我们能够参与大型的国家倡议 例如N3C和Recover，以及许多全州和地区性的合作。关键要素之一 我们的成功在于我们数据科学能力的发展，这些能力使协作 参与这些大型项目所需的数据共享。然而，我们的主要任务--和力量--是 我们支持、教育、促进和培训临床研究人员和基础科学家的能力 在转化性研究周期的所有阶段和所有阶段成功的临床和转化性研究 作为一个调查员的职业生涯。这项工作的一个关键部分是我们的临床和 翻译研究导航团队，这对我们各级临床研究人员的支持至关重要， 尤其是那些资历较浅的人。他们为每件事提供的宝贵的指导和资源 从概念化到研究设计、统计和调查方法、伦理培训，等等 对于临床研究人员的参与和成功来说是必不可少的。事实上，独一无二的 我们实施的创新研究导航模式非常成功，以至于有几个临床 MaineHealth的部门和服务线已经聘请了他们自己的研究导航员，我们有 支持并帮助培训我们制定的最佳做法。该模型的重点是构建 多学科团队由杰出的基础科学家和感兴趣、敬业的临床医生组成，他们分享 这些想法，从而确定共同的研究兴趣。它使机构内部和机构间都能够 我们两个医疗保健组织内部和之间的合作。作为一个自然的副产品和延伸 研究导航模型，我们将在接下来的时间里开发和提供CTR Research Design Studio课程 资助期。此外，我们将加强临床、研究和管理数据的整合，继续 参与国家倡议，如N3C和RECOVER，提供更多关于使用 在N3C飞地的Palantir平台和飞地的分析工具，并提供外联和培训 分析人员和调查人员使用ATLAS网络界面等工具访问我们的OMOP数据， 以及使用R和SHINY开发仪表板。我们将扩大合作，为以下领域带来更多机会 调查人员并与其他核心合作，提供技术支持，以推动成功的研究。

The goal of The Biostatistics, Epidemiology, and Research Design (BERD) Core is to support NNE-CTR Cores and investigators in the appropriate use of methodologies and computationally-intensive approaches and technologies for their studies. In the four-plus years since the NNE-CTR was funded, the BERD Core has invested considerable resources and personnel in building out our computational and data infrastructures, with a major goal of supporting and facilitating collaborative research among investigators at the biomedical institutions of northern New England. Our success has enabled our participation in large national initiatives such as N3C and RECOVER, as well as numerous state-wide and regional collaborations. A critical element of our success has been the development of our data science capabilities that have enabled the collaborative data sharing needed to participate in these large projects. However, our primary mandate -- and strength -- is our ability to support, educate, facilitate, and train clinical investigators and basic scientists in carrying out successful clinical and translational research at all stages of the translational research cycle and at all stages of an investigator's career. A key piece of this effort has been the continued development of our Clinical and Translational Research Navigation team, which is critical to the support of our clinical investigators at all levels, but particularly those who are more junior. The valuable guidance and resources they provide on everything from conceptualization to study design, statistical and survey methods, ethics training, and beyond is fundamentally necessary for the engagement and success of clinical investigators. In fact, the unique and innovative Research Navigation model we implemented has been so successful that several of the clinical departments and service lines at MaineHealth have hired their own research navigators, whom we have supported and helped to train in the best practices we developed. The model focuses on building multidisciplinary teams composed of outstanding basic scientists and interested, engaged clinicians who share ideas and thereby identify common research interests. It has enabled both intra- and inter-institutional collaboration within and between our two healthcare organizations. As a natural outgrowth and extension of the Research Navigation model, we will develop and offer CTR Research Design Studio sessions in this next funding period. Further, we will enhance the integration of clinical, research, and administrative data, continue to participate in national initiatives such as N3C and RECOVER, provide more intensive training in use of the Palantir platform in the N3C Enclave and the analytic tools in the Enclave, and provide outreach and training to analysts and investigators on the use of tools, such as the ATLAS web interface for accessing our OMOP data, and dashboard development using R and SHINY. We will expand collaborations to bring more opportunities to investigators and work with the other Cores to provide technical support to spur successful research.