CAP-IT CRI U54 ADMINISTRATIVE CORE

CAP-IT CRI U54 管理核心

• 批准号: 10505676
• 负责人: Steven M Lipkin
• 金额: $ 11.71万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10505676
• 关键词: American Association of Cancer Research; American Society of Clinical Oncology; Automobile Driving; Award; Cancer Center; Cancer Research Project; Clinical; Clinical Trials; Collaborations; Contracts; Dana-Farber Cancer Institute; Database Management Systems; Databases; Division of Cancer Prevention; Doctor of Philosophy; Emerging Technologies; Ensure; Evaluation; Genetic Databases; Genomics; Goals; Health Insurance Portability and Accountability Act; Hereditary Nonpolyposis Colorectal Neoplasms; IACUC; Immune Targeting; Immunooncology; Immunoprevention; Individual; Institute of Medicine (U.S.); Institutional Review Boards; International; Journals; Lead; Leadership; Malignant neoplasm of lung; Medicine; Mission; National Cancer Institute; Patients; Prevention Research; Productivity; Program Research Project Grants; RNA; RNA vaccine; Research; Research Personnel; Research Project Grants; Resource Sharing; Role; Site; Time; Translating; Translations; Vaccines; Validation; archive data; cancer prevention; cancer risk; clinical translation; data archive; data management; data sharing; editorial; experience; individualized prevention; meetings; member; pre-clinical; programs; targeted agent; tumor immunology; working group

Admin Core: Project Summary/Abstract A significant overall goal of CAP-IT is to identify and validate immunologically targeted agents for precision prevention of individuals with increased cancer risk. The CAP-IT Center for RNA Immunoprevention (CRI) Administrative Core (AC) mission is to ensure that research project/Core teams maintain focus on this overall goal. The AC will rapidly perform administrative functions that would otherwise serve as rate-limiting bottlenecks, including IRB/IACUC regulatory compliance and the establishment of MTA/DTAs between multiple project sites. The AC will integrate CRI U54 into the CAP-IT network and drive intra-network as well as international collaborations. To ensure CRI's scientific rigor and excellence, we have assembled a scientifically and administratively outstanding CRI External Advisory Board, including the 2021 Lasker Award winner Dr. Drew Weissman (U. Penn). The AC shall also seamlessly integrate genomic databases and emerging technology as shared resources (such as liponanoparticle RNA vaccines and immunopeptidomics) with the CAP-IT U24 DRCC. 1

Admin Core：admin CAP-IT的一个重要总体目标是识别和验证免疫靶向药物的精确性 预防癌症风险增加的个体。CAP-IT RNA免疫预防中心（CRI） 行政核心（AC）的使命是确保研究项目/核心团队保持对这一整体的关注 目标. AC将快速执行管理功能，否则这些功能将成为限速瓶颈， 包括IRB/IACUC监管合规性和多个项目地点之间MTA/DTA的建立。 AC将把CRI U 54集成到CAP-IT网络中，并推动网络内部以及国际 合作。为了确保CRI的科学严谨性和卓越性，我们组织了一个科学和 行政上杰出的CRI外部顾问委员会，包括2021年拉斯克奖赢家德鲁博士 韦斯曼（U. Penn）。AC还应无缝集成基因组数据库和新兴技术， 与CAP-IT U24 DRCC共享资源（如脂质纳米颗粒RNA疫苗和免疫肽组学）。 1