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IGF::OT::IGF TESTING OF COMBINATION IMMUNO AND CHEMOPREVENTION STRATEGIES FOR LYNCH SYNDROME GASTROINTESTINAL CANCER

IGF::OT::IGF TESTING OF COMBINATION IMMUNO AND CHEMOPREVENTION STRATEGIES FOR LYNCH SYNDROME GASTROINTESTINAL CANCER
IGF::OT::林奇综合征胃肠癌免疫和化学预防联合策略的 IGF 测试
批准号：
9443551
负责人：
Steven M Lipkin
金额：
$15.13万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
项目状态：
已结题
起止时间：
2015-09-24 至 2017-09-23
来源：
https://reporter.nih.gov/project-details/9443551
关键词：
ChemopreventionClinicalDevelopmentHereditary Nonpolyposis Colorectal NeoplasmsImmunotherapyMalignant neoplasm of gastrointestinal tractPeptide VaccinesPre-Clinical ModelTestingVaccinesmutantnovel vaccinessmall molecule

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中文摘要
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英文摘要
Recent progress has been made in clinical immunotherapy of gastrointestinal cancers associated with Lynch Syndrome using frame-shift mutant peptide vaccines. Further development of such strategies requires preclinical models for testing of next generation vaccines and combination strategies with small-molecules that may synergize with or augment the vaccine effects.
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