Investigation of Social and Circadian Rhythm Dysregulation in the Development of Depression Symptoms During the Menopause Transition
更年期过渡期间抑郁症状发展中社会和昼夜节律失调的调查
基本信息
- 批准号:10507660
- 负责人:
- 金额:$ 24.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-15 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAmenorrheaAttentionBloodCircadian DysregulationCircadian RhythmsClinicalCohort StudiesDataData CollectionDepressed moodDevelopmentEcological momentary assessmentEquilibriumEstradiolEstrogensFeedbackFollicle Stimulating HormoneFrequenciesFutureGoalsHormonalHormonal ChangeHormonesInterventionInterviewInvestigationLeadLifeLife StressLinkMajor Depressive DisorderMeasuresMediatingMenopauseMenstruationMental DepressionMethodsMoodsParticipantPathway interactionsPatient Self-ReportPerimenopausePersonsPhasePlant RootsPremenopausePreventionProceduresProgesteroneProxyQuestionnairesReportingResearchRestRisk ManagementRoleSamplingSerumSignal TransductionSleepStressStressful EventSymptomsTestingTimeWomanWristactigraphyaffective disturbanceagedbehavior influencecircadianclinical developmentclinically significantcontextual factorsdepressive symptomsexperiencefollow up assessmenthigh riskimprovedindexingpsychosocialrecruitreproductivereproductive hormonesaliva samplesleep onsetsocialstressortheories
项目摘要
Project Summary
The menopausal transition is a high-risk period for the development of clinically significant depression
symptoms in women. The likelihood of depression during the transition to menopause (i.e., perimenopause) is
approximately 3 times greater relative to the pre-menopause period. There is a critical need to understand the
mechanisms of these increased depression rates to optimally inform prevention and risk-management
strategies. Circadian rhythms are altered in menopause and have been linked to depression broadly and in
menopausal women specifically. Recent research has also shown that sensitivity to fluctuations in estrogen
may be linked to depression symptoms during this reproductive transition. What has yet to be thoroughly
elucidated is 1) the degree to which altered circadian rhythms are linked to the development of depression
symptoms during the perimenopausal period and 2) whether circadian alterations are influenced purely by
hormonal changes or also by environmental dysregulation of social rhythms. The goal of this R21 proposal is
to explore simultaneously the relationship of both hormonal and social rhythm influences on circadian rhythms
in women transitioning into menopause both with (n=20) and without (n=20) clinically significant symptoms of
major depressive disorder (MDD). Baseline assessments will include clinical interview and self-report
measures of depression, a detailed interview of current stressors and their impact on daily routines, and
questionnaires about sleep, chronotype, and social rhythm regularity. Participants will also complete a blood
draw for reproductive hormones estradiol and follicle stimulating hormone. Over the course of 4 weeks,
participants will provide morning salivary samples of estradiol and progesterone every 4 days for a total of 7
samples. Participants will also wear a wrist actigraph during the study period to examine rest/activity rhythms
and participate in once daily ecological momentary assessments of mood, stress, and routines allowing for
deeper analysis of contextual factors that may affect circadian rhythms and mood. At the end of week 4,
participants will undergo a repeat blood draw and complete follow-up assessments of stress and mood. These
methods will set the stage for an R01 that will investigate the mediational role of circadian and social rhythm
disruption in the development of depression symptoms in a large and diverse sample of perimenopausal
women.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Elaine M Boland其他文献
Affective Disruption From Social Rhythm and Behavioral Approach System (BAS) Sensitivities
社交节律和行为方法系统 (BAS) 敏感性的情感干扰
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Elaine M Boland;J. Stange;D. LaBelle;Benjamin G. Shapero;R. Weiss;L. Abramson;L. Alloy - 通讯作者:
L. Alloy
ATS Core Curriculum 2017: Part I. Adult Sleep Medicine
2017 年 ATS 核心课程:第一部分:成人睡眠医学
- DOI:
10.1513/annalsats.201701-028cme - 发表时间:
2017 - 期刊:
- 影响因子:8.3
- 作者:
S. Jamil;W. Conwell;Jason T Poston;Sarah Patel;M. Billings;Elaine M Boland;P. Gehrman;Melisa R. Chang;Jennifer L Martin;Sulaiman Khadadah;M. Kaminska;Rahul Sharma;L. Wolfe;Jihane Zaza Dit Yafawi;Terese C Hammond;S. D. de Cruz;J. Balachandran;Tisha Wang - 通讯作者:
Tisha Wang
High-Risk Designs
高风险设计
- DOI:
10.1002/9781118625392.wbecp080 - 发表时间:
2015 - 期刊:
- 影响因子:5.9
- 作者:
L. Alloy;Elaine M Boland - 通讯作者:
Elaine M Boland
CBT-I is an efficacious, first‐line treatment for insomnia: Where we need to go from here. A commentary on the application of Tolin's criteria to cognitive behavioral therapy for insomnia.
CBT-I 是一种有效的失眠一线治疗方法:关于托林标准在失眠认知行为治疗中的应用评论。
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
Erin M O'Brien;Elaine M Boland - 通讯作者:
Elaine M Boland
Elaine M Boland的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Elaine M Boland', 18)}}的其他基金
Investigation of Social and Circadian Rhythm Dysregulation in the Development of Depression Symptoms During the Menopause Transition
更年期过渡期间抑郁症状发展中社会和昼夜节律失调的调查
- 批准号:
10665761 - 财政年份:2022
- 资助金额:
$ 24.38万 - 项目类别:
The Role of Effort Discounting in the Link between Insomnia and Depression
努力折扣在失眠和抑郁之间的联系中的作用
- 批准号:
9349892 - 财政年份:2017
- 资助金额:
$ 24.38万 - 项目类别:
The Role of Effort Discounting in the Link between Insomnia and Depression
努力折扣在失眠和抑郁之间的联系中的作用
- 批准号:
10292892 - 财政年份:2017
- 资助金额:
$ 24.38万 - 项目类别:
The Role of Effort Discounting in the Link between Insomnia and Depression
努力折扣在失眠和抑郁之间的联系中的作用
- 批准号:
10563118 - 财政年份:2017
- 资助金额:
$ 24.38万 - 项目类别:
相似海外基金
Evolution of non-reproductive sexual behavior: Sexual receptivity during postpartum amenorrhea in bonobos
非生殖性行为的进化:倭黑猩猩产后闭经期间的性接受能力
- 批准号:
23KK0130 - 财政年份:2023
- 资助金额:
$ 24.38万 - 项目类别:
Fund for the Promotion of Joint International Research (International Collaborative Research)
Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular Health
下丘脑闭经作为心血管健康的生育状态标志
- 批准号:
10289995 - 财政年份:2021
- 资助金额:
$ 24.38万 - 项目类别:
Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular Health
下丘脑闭经作为心血管健康的生育状态标志
- 批准号:
10704785 - 财政年份:2021
- 资助金额:
$ 24.38万 - 项目类别:
Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular Health
下丘脑闭经作为心血管健康的生育状态标志
- 批准号:
10669706 - 财政年份:2021
- 资助金额:
$ 24.38万 - 项目类别:
Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular Health
下丘脑闭经作为心血管健康的生育状态标志
- 批准号:
10477353 - 财政年份:2021
- 资助金额:
$ 24.38万 - 项目类别:
Understanding the Lactational Amenorrhea Method of Contraception for Mothers of Preterm and Term Infants
了解早产儿和足月儿母亲哺乳期闭经的避孕方法
- 批准号:
9385677 - 财政年份:2017
- 资助金额:
$ 24.38万 - 项目类别:
NOREPINEPHRINE IN STRESS-INDUCED AMENORRHEA OF MACAQUES
去甲肾上腺素在压力引起的猕猴闭经中的作用
- 批准号:
8357842 - 财政年份:2011
- 资助金额:
$ 24.38万 - 项目类别:
SINGLE NUCLEOTIDE GENE POLYMORPHISMS AND FUNCTIONAL HYPOTHALAMIC AMENORRHEA
单核苷酸基因多态性与功能性下丘脑性闭经
- 批准号:
8173254 - 财政年份:2010
- 资助金额:
$ 24.38万 - 项目类别:
Norepinephrine in Stress-Induced Amenorrhea of Macaques
去甲肾上腺素在压力引起的猕猴闭经中的作用
- 批准号:
8116585 - 财政年份:2010
- 资助金额:
$ 24.38万 - 项目类别:
Norepinephrine in Stress-Induced Amenorrhea of Macaques
去甲肾上腺素在压力引起的猕猴闭经中的作用
- 批准号:
7771494 - 财政年份:2010
- 资助金额:
$ 24.38万 - 项目类别: