Investigation of Social and Circadian Rhythm Dysregulation in the Development of Depression Symptoms During the Menopause Transition

更年期过渡期间抑郁症状发展中社会和昼夜节律失调的调查

基本信息

  • 批准号:
    10507660
  • 负责人:
  • 金额:
    $ 24.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-07-15 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary The menopausal transition is a high-risk period for the development of clinically significant depression symptoms in women. The likelihood of depression during the transition to menopause (i.e., perimenopause) is approximately 3 times greater relative to the pre-menopause period. There is a critical need to understand the mechanisms of these increased depression rates to optimally inform prevention and risk-management strategies. Circadian rhythms are altered in menopause and have been linked to depression broadly and in menopausal women specifically. Recent research has also shown that sensitivity to fluctuations in estrogen may be linked to depression symptoms during this reproductive transition. What has yet to be thoroughly elucidated is 1) the degree to which altered circadian rhythms are linked to the development of depression symptoms during the perimenopausal period and 2) whether circadian alterations are influenced purely by hormonal changes or also by environmental dysregulation of social rhythms. The goal of this R21 proposal is to explore simultaneously the relationship of both hormonal and social rhythm influences on circadian rhythms in women transitioning into menopause both with (n=20) and without (n=20) clinically significant symptoms of major depressive disorder (MDD). Baseline assessments will include clinical interview and self-report measures of depression, a detailed interview of current stressors and their impact on daily routines, and questionnaires about sleep, chronotype, and social rhythm regularity. Participants will also complete a blood draw for reproductive hormones estradiol and follicle stimulating hormone. Over the course of 4 weeks, participants will provide morning salivary samples of estradiol and progesterone every 4 days for a total of 7 samples. Participants will also wear a wrist actigraph during the study period to examine rest/activity rhythms and participate in once daily ecological momentary assessments of mood, stress, and routines allowing for deeper analysis of contextual factors that may affect circadian rhythms and mood. At the end of week 4, participants will undergo a repeat blood draw and complete follow-up assessments of stress and mood. These methods will set the stage for an R01 that will investigate the mediational role of circadian and social rhythm disruption in the development of depression symptoms in a large and diverse sample of perimenopausal women.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Elaine M Boland其他文献

Affective Disruption From Social Rhythm and Behavioral Approach System (BAS) Sensitivities
社交节律和行为方法系统 (BAS) 敏感性的情感干扰
ATS Core Curriculum 2017: Part I. Adult Sleep Medicine
2017 年 ATS 核心课程:第一部分:成人睡眠医学
  • DOI:
    10.1513/annalsats.201701-028cme
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    8.3
  • 作者:
    S. Jamil;W. Conwell;Jason T Poston;Sarah Patel;M. Billings;Elaine M Boland;P. Gehrman;Melisa R. Chang;Jennifer L Martin;Sulaiman Khadadah;M. Kaminska;Rahul Sharma;L. Wolfe;Jihane Zaza Dit Yafawi;Terese C Hammond;S. D. de Cruz;J. Balachandran;Tisha Wang
  • 通讯作者:
    Tisha Wang
High-Risk Designs
高风险设计
  • DOI:
    10.1002/9781118625392.wbecp080
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    5.9
  • 作者:
    L. Alloy;Elaine M Boland
  • 通讯作者:
    Elaine M Boland
CBT-I is an efficacious, first‐line treatment for insomnia: Where we need to go from here. A commentary on the application of Tolin's criteria to cognitive behavioral therapy for insomnia.
CBT-I 是一种有效的失眠一线治疗方法:关于托林标准在失眠认知行为治疗中的应用评论。
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Erin M O'Brien;Elaine M Boland
  • 通讯作者:
    Elaine M Boland

Elaine M Boland的其他文献

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{{ truncateString('Elaine M Boland', 18)}}的其他基金

Investigation of Social and Circadian Rhythm Dysregulation in the Development of Depression Symptoms During the Menopause Transition
更年期过渡期间抑郁症状发展中社会和昼夜节律失调的调查
  • 批准号:
    10665761
  • 财政年份:
    2022
  • 资助金额:
    $ 24.38万
  • 项目类别:
The Role of Effort Discounting in the Link between Insomnia and Depression
努力折扣在失眠和抑郁之间的联系中的作用
  • 批准号:
    9349892
  • 财政年份:
    2017
  • 资助金额:
    $ 24.38万
  • 项目类别:
The Role of Effort Discounting in the Link between Insomnia and Depression
努力折扣在失眠和抑郁之间的联系中的作用
  • 批准号:
    10292892
  • 财政年份:
    2017
  • 资助金额:
    $ 24.38万
  • 项目类别:
The Role of Effort Discounting in the Link between Insomnia and Depression
努力折扣在失眠和抑郁之间的联系中的作用
  • 批准号:
    10563118
  • 财政年份:
    2017
  • 资助金额:
    $ 24.38万
  • 项目类别:

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