A minimally Invasive surgical platform aGainst paNcreatIc and biliary Tract cancErs using cold atmospheric PLASMA

使用冷大气等离子体治疗胰腺癌和胆道癌的微创手术平台

• 批准号: 10106237
• 金额: $ 21.85万
• 依托单位: SYNNOUS LIMITED
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10106237
• 关键词: minimally; Invasive; surgical; platform; aGainst

Cancer is one of the major causes of death in Europe. Pancreatic (PC) and biliary tract (BTC) cancer are rare gastrointestinal adenocarcinomas with an increasing incidence particularly among the elderly and women in an ageing European population, and a poor prognosis poses major clinical challenges and public health burden. Cold atmospheric pressure plasma (CAP) has shown potential regressing various cancer types in the laboratory setting. Owing to their properties, CAP is a unique source of high concentrations of reactive radicals, electrons, ions, UV etc. that may induce various effects in living tissue. CAP has shown selectivity in where cancer cells are treated with minimal effect to healthy ones; this renders plasma suitable to treat carcinomas in very sensitive areas or organs where an unmet need to minimise damage/side-effects exists. CAP can be delivered through dielectric tubes of variable length, which makes it ideal for minimally invasive and precise laparoscopic and endoscopic operations. Despite the great promise and potential of this concept, there is no single laparoscopic or endoscopic medical platform in the market today based on CAP to treat carcinomas. This project proposes a novel solution using cutting-edge plasma technology, in-silico models, and a system-level approach. It will combine plasma with tumour multiscale simulations and will take input from pre-surgery diagnostics for in-silico model initialisation and CAP operational window determination. The developed technology will be demonstrated through in-vivo experiments, while the foundations for clinical trials and market introduction for CAP-based care of PC/BTCs will be laid out in this project.

癌症是欧洲死亡的主要原因之一。胰腺（PC）和胆道（BTC）癌症是罕见的胃肠道腺癌，尤其是欧洲老龄化的老年人和妇女的发病率越来越高，预后较差会带来重大的临床挑战和公共卫生负担。冷大气压等离子体（CAP）显示了实验室环境中各种癌症类型的潜在消退。由于其特性，CAP是高浓度的反应性自由基，电子，离子，紫外线等的独特来源，可能会在生物组织中引起各种影​​响。 CAP在对健康的癌细胞中对癌细胞的治疗中的选择性最小。这使血浆适合于在非常敏感的区域或器官中治疗癌，在这些区域或器官中需要最大程度地减少损害/副作用。盖可以通过可变长度的介电管传递，这使其非常适合微创和精确的腹腔镜和内窥镜操作。尽管这个概念具有很大的希望和潜力，但根据治疗癌的CAP，当今市场上没有单一的腹腔镜或内窥镜医疗平台。该项目提出了一种新的解决方案，使用尖端的等离子技术，内部模型和系统级别的方法。它将将血浆与肿瘤多尺度模拟相结合，并将从术前诊断中的输入中进行内部模型初始化和CAP操作窗口测定。该项目将通过体内实验来证明开发的技术，而临床试验和市场介绍基于PC/BTC的CAP护理的基础将在该项目中阐明。