A minimally Invasive surgical platform aGainst paNcreatIc and biliary Tract cancErs using cold atmospheric PLASMA

使用冷大气等离子体治疗胰腺癌和胆道癌的微创手术平台

• 批准号: 10106237
• 金额: $ 21.85万
• 依托单位: SYNNOUS LIMITED
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10106237
• 关键词: minimally; Invasive; surgical; platform; aGainst

Cancer is one of the major causes of death in Europe. Pancreatic (PC) and biliary tract (BTC) cancer are rare gastrointestinal adenocarcinomas with an increasing incidence particularly among the elderly and women in an ageing European population, and a poor prognosis poses major clinical challenges and public health burden. Cold atmospheric pressure plasma (CAP) has shown potential regressing various cancer types in the laboratory setting. Owing to their properties, CAP is a unique source of high concentrations of reactive radicals, electrons, ions, UV etc. that may induce various effects in living tissue. CAP has shown selectivity in where cancer cells are treated with minimal effect to healthy ones; this renders plasma suitable to treat carcinomas in very sensitive areas or organs where an unmet need to minimise damage/side-effects exists. CAP can be delivered through dielectric tubes of variable length, which makes it ideal for minimally invasive and precise laparoscopic and endoscopic operations. Despite the great promise and potential of this concept, there is no single laparoscopic or endoscopic medical platform in the market today based on CAP to treat carcinomas. This project proposes a novel solution using cutting-edge plasma technology, in-silico models, and a system-level approach. It will combine plasma with tumour multiscale simulations and will take input from pre-surgery diagnostics for in-silico model initialisation and CAP operational window determination. The developed technology will be demonstrated through in-vivo experiments, while the foundations for clinical trials and market introduction for CAP-based care of PC/BTCs will be laid out in this project.

癌症是欧洲主要的死亡原因之一。胰腺癌（PC）和胆道癌（BTC）是罕见的胃肠道腺癌，其发病率不断增加，特别是在欧洲老龄化人口中的老年人和女性中，预后不良给临床带来了重大挑战和公共卫生负担。冷大气压等离子体 (CAP) 在实验室环境中显示出治愈多种癌症的潜力。由于其特性，CAP 是高浓度反应性自由基、电子、离子、紫外线等的独特来源，可能对活体组织产生各种影响。 CAP 在治疗癌细胞方面表现出选择性，对健康细胞的影响最小；这使得血浆适合治疗非常敏感区域或器官的癌症，这些区域或器官存在未满足的最小化损害/副作用的需求。 CAP 可以通过可变长度的介电管输送，这使其成为微创和精确的腹腔镜和内窥镜手术的理想选择。尽管这一概念具有巨大的前景和潜力，但目前市场上还没有基于 CAP 的单一腹腔镜或内窥镜医疗平台来治疗癌症。该项目提出了一种采用尖端等离子体技术、计算机模型和系统级方法的新颖解决方案。它将等离子体与肿瘤多尺度模拟相结合，并将从术前诊断中获取输入，用于计算机模型初始化和 CAP 操作窗口确定。所开发的技术将通过体内实验进行论证，同时该项目也将为基于 CAP 的 PC/BTC 护理的临床试验和市场推广奠定基础。