Exposure to volatile organic compounds and glycemic dysregulation among oil spill cleanup workers

溢油清理工人接触挥发性有机化合物和血糖失调

• 批准号: 10520015
• 负责人: Hanna Jardel
• 金额: $ 4.01万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10520015
• 关键词: Address; Affect; African American population; Air; Animals; Benzene; Blood; Categories; Chemicals; Clinical; Clinical assessments; Cohort Analysis; Collaborations; Communication; Data; Development; Diabetes Mellitus; Disasters; Disease; Disparity; Environmental Epidemiology; Environmental Risk Factor; Epidemiology; Ethnic Origin; Ethnic Population; Etiology; Exposure disparity; Exposure to; Follow-Up Studies; Functional disorder; General Population; Glycosylated Hemoglobin; Glycosylated hemoglobin A; Goals; Health; Hemoglobin concentration result; Hexanes; Hispanic Americans; Human; Hydrocarbons; Individual; Investigation; Joints; Knowledge; Literature; Longitudinal Studies; Longterm Follow-up; Measurement; Medical Care Costs; Methods; Mexico; Minority Groups; Native Americans; Occupational Exposure; Occupations; Oils; Outcome; Oxidation-Reduction; Oxidative Stress; Participant; Petroleum; Population; Prevalence; Process; Prospective cohort; Race; Recording of previous events; Regulation; Research; Research Personnel; Role; Societies; Socioeconomic Status; Time; Toluene; Toxicology; Training; Work; Workplace; Writing; Xylene; career; career networking; clinical diagnosis; cohort; diabetes risk; empowerment; environmental disparity; epidemiology study; ethnic disparity; ethylbenzene; experience; follow-up; health data; indexing; lifestyle data; low socioeconomic status; marine; racial disparity; racial population; response; responsible research conduct; skills; social disparities; socioeconomic disparity; socioeconomics; spatiotemporal; theories; volatile organic compound

Project Abstract Diabetes, the clinical manifestation of glycemic dysregulation, leads to devastating complications as well as high medical costs for both the individual and society. Diabetes is increasing in prevalence and is disproportionately high among certain minority populations, and particularly among those of low socioeconomic status within those populations. Limited evidence suggests a role of environmental factors in the etiology of glycemic dysregulation and highlights the need for further research to better understand these relationships. Exposure to the BTEX-H (benzene, toluene, ethylbenzene, xylenes, and hexane) mixture is ubiquitous and is associated with glycemic dysregulation in epidemiologic and toxicological studies, but there are clear gaps in the literature. One gap is in the assessment and analysis of exposures; previous work primarily addresses the BTEX-H chemicals singly, and not all of the BTEX-H chemicals have been investigated as such. In contrast the BTEX-H chemicals are often experienced jointly and must be analyzed accordingly. Additionally, previous work has not incorporated individuals with large magnitude and varied exposures, making it difficult to isolate exposure effects. The proposed research will address these gaps by analyzing these associations in a well- characterized, prospective cohort of oil-spill workers with a wide range of exposures using mixtures analysis methods. The goals of this proposal are a) to examine real-world exposure effects of BTEX-H mixtures on incident diabetes up to 10 years post-exposure among a cohort of oil spill workers, b) to determine racial/ethnic and socioeconomic category specific exposure burden, outcome burden, and BTEX-H mixture to clinical diabetes associations, and c) to examine the effect of BTEX-H mixture exposure on glycemic dysregulation by relating the mixture to i) glycosylated hemoglobin levels and ii) change in glycosylated hemoglobin levels between two time points up to 5 years apart. My training plan will allow me to further develop the skills necessary to complete the proposed research and to pursue a successful career as an independent researcher. These skills are a) to become fluent in exposure mixtures theory and analysis methods; b) to develop skills in operationalizing socioeconomic and racial disparities processes in quantitative research; c) to further develop skills necessary for a strong scientific career by refining my written communication, expanding my professional network for collaboration, and further evolving my presentation strategies; and d) to obtain additional training in the responsible conduct of research, especially in the context of disaster and environmental epidemiology research. This training will propel me toward my goal of studying long-term health outcomes at the intersection of disasters, environmental exposures, and social disparities processes.

项目摘要 糖尿病是血糖调节失调的临床表现，它会导致毁灭性的并发症以及 个人和社会的医疗费用都很高。糖尿病的患病率正在增加，而且 在某些少数群体中，特别是在社会经济水平较低的人群中，比例过高 在这些人群中的地位。有限的证据表明环境因素在该病的病因中起到了作用 并强调了进一步研究以更好地了解这些关系的必要性。 接触BTEX-H(苯、甲苯、乙苯、二甲苯和己烷)混合物是普遍存在的，而且 在流行病学和毒理学研究中与血糖调节失调有关，但在 文学作品。一个差距是在风险暴露的评估和分析方面；以前的工作主要解决 只对苯系物-H化学品进行了调查，并不是所有的苯系物-H化学品都进行了调查。与之形成对比的是 BTEX-H化学品通常是共同经历的，必须进行相应的分析。此外，以前的工作 没有纳入大量和不同接触的个人，因此很难分离出来 曝光效果。拟议的研究将通过分析这些关联来解决这些差距- 使用混合物分析确定具有广泛暴露范围的漏油工人的特征、预期队列 方法：研究方法。这项建议的目标是a)检查BTEX-H混合物在 在石油泄漏工人队列中暴露后长达10年的事件糖尿病，b)确定种族/民族 以及社会经济类别特定暴露负担、结果负担和苯系物-H混合物对临床的影响 糖尿病关系，以及c)研究苯系物-H混合物暴露对血糖调节失调的影响 该混合物与i)糖化血红蛋白水平和ii)糖化血红蛋白水平的变化有关 在两个时间点之间，相隔长达5年。 我的培训计划将使我能够进一步发展完成拟议研究所需的技能，并 追求作为一名独立研究人员的成功职业生涯。这些技能是a)在曝光时变得流利 混合理论和分析方法；b)培养运用社会经济和种族的技能 定量研究中的差异过程；c)进一步发展强大的科学研究所需的技能 通过完善我的书面交流，扩展我的专业协作网络，以及进一步 发展我的演示策略；以及d)获得负责任的研究指导方面的额外培训， 特别是在灾害和环境流行病学研究的背景下。这次训练会给我带来动力 朝着我的目标是研究灾难、环境和环境交汇处的长期健康结果 曝光率和社会差距进程。