Exposure to volatile organic compounds and glycemic dysregulation among oil spill cleanup workers

溢油清理工人接触挥发性有机化合物和血糖失调

基本信息

  • 批准号:
    10520015
  • 负责人:
  • 金额:
    $ 4.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-12-01 至 2023-11-30
  • 项目状态:
    已结题

项目摘要

Project Abstract Diabetes, the clinical manifestation of glycemic dysregulation, leads to devastating complications as well as high medical costs for both the individual and society. Diabetes is increasing in prevalence and is disproportionately high among certain minority populations, and particularly among those of low socioeconomic status within those populations. Limited evidence suggests a role of environmental factors in the etiology of glycemic dysregulation and highlights the need for further research to better understand these relationships. Exposure to the BTEX-H (benzene, toluene, ethylbenzene, xylenes, and hexane) mixture is ubiquitous and is associated with glycemic dysregulation in epidemiologic and toxicological studies, but there are clear gaps in the literature. One gap is in the assessment and analysis of exposures; previous work primarily addresses the BTEX-H chemicals singly, and not all of the BTEX-H chemicals have been investigated as such. In contrast the BTEX-H chemicals are often experienced jointly and must be analyzed accordingly. Additionally, previous work has not incorporated individuals with large magnitude and varied exposures, making it difficult to isolate exposure effects. The proposed research will address these gaps by analyzing these associations in a well- characterized, prospective cohort of oil-spill workers with a wide range of exposures using mixtures analysis methods. The goals of this proposal are a) to examine real-world exposure effects of BTEX-H mixtures on incident diabetes up to 10 years post-exposure among a cohort of oil spill workers, b) to determine racial/ethnic and socioeconomic category specific exposure burden, outcome burden, and BTEX-H mixture to clinical diabetes associations, and c) to examine the effect of BTEX-H mixture exposure on glycemic dysregulation by relating the mixture to i) glycosylated hemoglobin levels and ii) change in glycosylated hemoglobin levels between two time points up to 5 years apart. My training plan will allow me to further develop the skills necessary to complete the proposed research and to pursue a successful career as an independent researcher. These skills are a) to become fluent in exposure mixtures theory and analysis methods; b) to develop skills in operationalizing socioeconomic and racial disparities processes in quantitative research; c) to further develop skills necessary for a strong scientific career by refining my written communication, expanding my professional network for collaboration, and further evolving my presentation strategies; and d) to obtain additional training in the responsible conduct of research, especially in the context of disaster and environmental epidemiology research. This training will propel me toward my goal of studying long-term health outcomes at the intersection of disasters, environmental exposures, and social disparities processes.
项目摘要 糖尿病,血糖失调的临床表现,导致毁灭性的并发症,以及 对个人和社会来说,医疗费用都很高。糖尿病的患病率正在上升, 在某些少数群体中,特别是在社会经济地位低下的少数群体中, 在这些人群中的地位。有限的证据表明,环境因素的作用,在病因 血糖失调,并强调需要进一步的研究,以更好地了解这些关系。 暴露于BTEX-H(苯、甲苯、二甲苯、二甲苯和己烷)混合物是普遍存在的, 在流行病学和毒理学研究中与血糖失调有关,但在 文学作品一个差距是在评估和分析暴露方面;以前的工作主要涉及 BTEX-H化学品单独使用,而不是所有的BTEX-H化学品都进行了研究。相比之下 BTEX-H化学品通常是共同经历的,必须进行相应的分析。此外,以前的工作 并没有纳入具有大规模和不同暴露的个人,因此难以隔离 暴露效应拟议的研究将通过分析这些关联来解决这些差距- 使用混合物分析的具有广泛暴露范围的溢油工人的特征性、前瞻性队列 方法.本提案的目标是:a)检查BTEX-H混合物对以下人群的真实暴露影响: 在一组石油泄漏工人中,暴露后10年内发生糖尿病,B)以确定种族/民族 和社会经济类别的特定暴露负担,结果负担,以及BTEX-H混合物对临床 糖尿病协会,和c)检查BTEX-H混合物暴露对血糖失调的影响, 将混合物与i)糖化血红蛋白水平和ii)糖化血红蛋白水平的变化相关联 在两个时间点之间,间隔长达5年。 我的培训计划将使我能够进一步发展完成拟议研究所需的技能, 作为一名独立的研究人员追求成功的职业生涯。这些技能是a)在接触中变得流利 混合物理论和分析方法; B)发展操作社会经济和种族 在定量研究中的差距过程; c)进一步发展必要的技能,以加强科学研究 通过完善我的书面交流,扩大我的专业合作网络,并进一步 发展我的演讲策略;以及d)在负责任的研究行为方面获得额外的培训, 特别是在灾害和环境流行病学研究方面。这次训练会让我 我的目标是研究在灾害、环境和自然灾害的交叉点上的长期健康结果, 暴露和社会差异过程。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Hanna Jardel其他文献

Hanna Jardel的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Hanna Jardel', 18)}}的其他基金

Exposure to volatile organic compounds and glycemic dysregulation among oil spill cleanup workers
溢油清理工人接触挥发性有机化合物和血糖失调
  • 批准号:
    10312459
  • 财政年份:
    2021
  • 资助金额:
    $ 4.01万
  • 项目类别:

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 4.01万
  • 项目类别:
    Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 4.01万
  • 项目类别:
    Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 4.01万
  • 项目类别:
    Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 4.01万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 4.01万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 4.01万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 4.01万
  • 项目类别:
    Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
  • 批准号:
    2301846
  • 财政年份:
    2023
  • 资助金额:
    $ 4.01万
  • 项目类别:
    Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 4.01万
  • 项目类别:
    Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
  • 批准号:
    23K16076
  • 财政年份:
    2023
  • 资助金额:
    $ 4.01万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了