Exposure to volatile organic compounds and glycemic dysregulation among oil spill cleanup workers

溢油清理工人接触挥发性有机化合物和血糖失调

• 批准号: 10520015
• 负责人: Hanna Jardel
• 金额: $ 4.01万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10520015
• 关键词: Address; Affect; African American population; Air; Animals; Benzene; Blood; Categories; Chemicals; Clinical; Clinical assessments; Cohort Analysis; Collaborations; Communication; Data; Development; Diabetes Mellitus; Disasters; Disease; Disparity; Environmental Epidemiology; Environmental Risk Factor; Epidemiology; Ethnic Origin; Ethnic Population; Etiology; Exposure disparity; Exposure to; Follow-Up Studies; Functional disorder; General Population; Glycosylated Hemoglobin; Glycosylated hemoglobin A; Goals; Health; Hemoglobin concentration result; Hexanes; Hispanic Americans; Human; Hydrocarbons; Individual; Investigation; Joints; Knowledge; Literature; Longitudinal Studies; Longterm Follow-up; Measurement; Medical Care Costs; Methods; Mexico; Minority Groups; Native Americans; Occupational Exposure; Occupations; Oils; Outcome; Oxidation-Reduction; Oxidative Stress; Participant; Petroleum; Population; Prevalence; Process; Prospective cohort; Race; Recording of previous events; Regulation; Research; Research Personnel; Role; Societies; Socioeconomic Status; Time; Toluene; Toxicology; Training; Work; Workplace; Writing; Xylene; career; career networking; clinical diagnosis; cohort; diabetes risk; empowerment; environmental disparity; epidemiology study; ethnic disparity; ethylbenzene; experience; follow-up; health data; indexing; lifestyle data; low socioeconomic status; marine; racial disparity; racial population; response; responsible research conduct; skills; social disparities; socioeconomic disparity; socioeconomics; spatiotemporal; theories; volatile organic compound

Project Abstract Diabetes, the clinical manifestation of glycemic dysregulation, leads to devastating complications as well as high medical costs for both the individual and society. Diabetes is increasing in prevalence and is disproportionately high among certain minority populations, and particularly among those of low socioeconomic status within those populations. Limited evidence suggests a role of environmental factors in the etiology of glycemic dysregulation and highlights the need for further research to better understand these relationships. Exposure to the BTEX-H (benzene, toluene, ethylbenzene, xylenes, and hexane) mixture is ubiquitous and is associated with glycemic dysregulation in epidemiologic and toxicological studies, but there are clear gaps in the literature. One gap is in the assessment and analysis of exposures; previous work primarily addresses the BTEX-H chemicals singly, and not all of the BTEX-H chemicals have been investigated as such. In contrast the BTEX-H chemicals are often experienced jointly and must be analyzed accordingly. Additionally, previous work has not incorporated individuals with large magnitude and varied exposures, making it difficult to isolate exposure effects. The proposed research will address these gaps by analyzing these associations in a well- characterized, prospective cohort of oil-spill workers with a wide range of exposures using mixtures analysis methods. The goals of this proposal are a) to examine real-world exposure effects of BTEX-H mixtures on incident diabetes up to 10 years post-exposure among a cohort of oil spill workers, b) to determine racial/ethnic and socioeconomic category specific exposure burden, outcome burden, and BTEX-H mixture to clinical diabetes associations, and c) to examine the effect of BTEX-H mixture exposure on glycemic dysregulation by relating the mixture to i) glycosylated hemoglobin levels and ii) change in glycosylated hemoglobin levels between two time points up to 5 years apart. My training plan will allow me to further develop the skills necessary to complete the proposed research and to pursue a successful career as an independent researcher. These skills are a) to become fluent in exposure mixtures theory and analysis methods; b) to develop skills in operationalizing socioeconomic and racial disparities processes in quantitative research; c) to further develop skills necessary for a strong scientific career by refining my written communication, expanding my professional network for collaboration, and further evolving my presentation strategies; and d) to obtain additional training in the responsible conduct of research, especially in the context of disaster and environmental epidemiology research. This training will propel me toward my goal of studying long-term health outcomes at the intersection of disasters, environmental exposures, and social disparities processes.

项目摘要 糖尿病是血糖失调的临床表现，导致毁灭性并发症以及 个人和社会的医疗费用很高。糖尿病的患病率正在增加，是 在某些少数群体中，尤其是社会经济低的人群中的高度不成比例 这些人群中的状态。有限的证据表明环境因素在病因中的作用 血糖失调并强调需要进一步研究以更好地理解这些关系。 暴露于BTEX-H（苯，甲苯，乙烯苯，Xylenes和己烷）混合物无处不在，并且是 在流行病学和毒理学研究中与血糖失调有关，但是 文学。一个差距是对暴露的评估和分析；以前的工作主要解决 BTEX-H化学物质是单独研究的，并非所有BTEX-H化学物质都已被研究。相比之下 BTEX-H化学物质通常是共同经历的，必须相应地进行分析。此外，以前的工作 尚未合并大小和多样的曝光的人，因此很难分离 暴露效果。拟议的研究将通过分析这些关联来解决这些差距 使用混合物分析的，具有广泛暴露的油性工人的特征，前瞻性队列 方法。该提案的目标是a）检查BTEX-H混合物对现实世界的暴露效果 一群漏油工人的暴露后长达10年的事件糖尿病，b）确定种族/族裔 和社会经济类别特定的暴露负担，结果负担和BTEX-H混合物 糖尿病关联，c）检查BTEX-H混合物暴露对血糖失调的影响 将混合物与i）糖基化血红蛋白水平和ii）变化糖基化血红蛋白水平变化 在两个时间点之间，相距5年。 我的培训计划将使我能够进一步发展完成拟议的研究和 从事独立研究人员的成功职业。这些技能是a）流利的曝光 混合理论和分析方法； b）发展社会经济和种族的技能 定量研究中的差异过程； c）进一步发展强大科学所必需的技能 通过完善我的书面沟通，扩大我的专业网络进行协作，并进一步 发展我的演讲策略； d）为了获得负责任的研究的额外培训， 特别是在灾难和环境流行病学研究的背景下。这项培训将推动我 为了在灾难的交集中研究长期健康结果的目标 暴露和社会差异过程。