BLRD Research Career Scientist Award Application
BLRD 研究职业科学家奖申请
基本信息
- 批准号:10514630
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-10-01 至 2025-09-30
- 项目状态:未结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeAdrenal Cortex HormonesAnimal ModelAntifungal AgentsAntifungal TherapyAspergillus fumigatusAutoimmune DiseasesAwardBiological AssayBrainCD4 Positive T LymphocytesCandida albicansCell CountCellsCeramidesCessation of lifeClinicClinicalCollaborationsCommunicable DiseasesCommunitiesContainmentCryptococcal MeningitisCryptococcosisCryptococcusCryptococcus neoformansDependenceDevelopmentDiseaseDrug DesignDrug FormulationsDrug resistanceEducational process of instructingEffectivenessEnsureEnvironmentEnzymesExposure toFacultyFungal VaccinesGeneral PopulationGlucosylceramidesGoalsGranulomaGrowthHIVHandHost DefenseImmune EvasionImmune systemImmunityImmunocompromised HostIndustryInfectionInjectionsInositolIntegration Host FactorsInterventionInvestigationKnowledgeLaboratoriesLipidsLungMalignant NeoplasmsMediatingMedicalMedical centerMolecularMorbidity - disease rateMycosesOrgan TransplantationOrganismPathogenesisPathogenicityPathway interactionsPatientsPharmaceutical ChemistryPharmaceutical PreparationsPhenotypePhysiciansPopulationPostdoctoral FellowPredispositionPreventiveProcessResearchResearch PersonnelResistanceSPHK1 enzymeScientistServicesSourceSouth CarolinaSpecificitySphingolipidsSphingomyelinsSpinal CordStructureStudentsSubstance abuse problemSymptomsTechnologyTestingThe science of MycologyTherapeuticTherapeutic immunosuppressionToxic effectToxicologyTrainingUniversitiesVeteransVirulenceWorkcareerchemotherapycross reactivitydesignexperiencefungushigh throughput screeningimmunoregulationinhibitorinterestmicrobialmicroorganism interactionmilitary servicemortalitymultiple sclerosis treatmentnovelnovel therapeutic interventionnovel therapeuticsopportunistic pathogenpatient populationresearch and developmentsmall moleculesphingomyelin synthasesphingosine 1-phosphatetherapeutically effective
项目摘要
ABSTRACT
I am an Infectious Diseases physician-scientist with over 28 years of experience in medical mycology.
During my career, I have been working in the clinic and at the bench, teaching and training many
students, post-docs and junior faculty at Duke University, the Medical University of South Carolina,
and now at Stony Brook University and at the Northport VA Medical Center. My overall career goal is
to bring a new antifungal in the clinic, and I am closer than ever with MicroRid Technologies Inc., a
start-up company I co-founded for the research and development of new antifungal drugs.
My laboratory pioneered the studies on lipid-mediated infectious diseases. My lab and my co-workers
reached such a high visibility in this field that we are continuously contacted for consultant work by
investigators from all over the world for lipid analysis in their favorite organisms. My studies have
mostly focused on fungal infections, particularly invasive fungal infections, because they are on the
rise in our Veterans and in our non-Veterans populations. As we live longer thanks to many benefits of
chemo- and immunosuppressive-therapies and organ transplantations, we are also facing a rise of
invasive fungal infectious diseases. Current antifungals are either fungistatic, toxic, with narrow
spectrum of activity or they become resistant. New treatment strategies are needed. In addition to
develop a new class of antifungal agents, the studies in my laboratory are also crucial to the
understanding of the host mechanisms required for fungal containment versus fungal dissemination
and disease. For these studies, I partnered with many collaborators at the VA medical centers, at
various Universities, and at the industry setting, establishing fruitful and successful collaborations. The
VA RCS award will allow our group to continue this great work and will provide stability to fulfill the
current goals and to start new research directions. The RCS Award will also allow me to broaden my
collaborative research even further, particularly with the VA physicians involved in the MVP,
enhancing my research clinical enterprise, and to continue my service to the scientific community at
the VA and beyond.
摘要
我是一名传染病内科医生兼科学家,在医学真菌学方面有超过28年的经验。
在我的职业生涯中,我一直在诊所和替补席上工作,教授和培训了许多
杜克大学、南卡罗来纳医科大学的学生、博士后和初级教职员工,
现在在石溪大学和诺斯波特退伍军人医学中心。我的总体职业目标是
将一种新的抗真菌药物带到临床上,我比以往任何时候都更接近MicroRid Technologies Inc.,一家
我与人共同创立了一家研究和开发新型抗真菌药物的初创公司。
我的实验室开创了脂质介导的传染病研究的先河。我的实验室和我的同事
在该领域达到如此高的知名度,以至于我们不断被联系以进行咨询工作
来自世界各地的研究人员对他们最喜欢的生物体进行脂质分析。我的研究已经
主要集中在真菌感染,特别是侵袭性真菌感染,因为它们在
退伍军人和非退伍军人人数的增加。因为我们活得更长,这要归功于
化疗和免疫抑制疗法以及器官移植,我们也面临着越来越多的
侵袭性真菌传染病。目前的抗真菌药物要么有抑菌作用,要么有毒,
否则它们就会产生抵抗力。需要新的治疗策略。除了……之外
开发一类新的抗真菌药物,我实验室的研究对
了解真菌遏制与真菌传播所需的宿主机制
和疾病。在这些研究中,我与退伍军人管理局医疗中心的许多合作者合作,网址为
在不同的大学和行业建立了卓有成效的成功合作。这个
弗吉尼亚RCS奖将使我们的团队继续这项伟大的工作,并将提供稳定,以实现
目前的目标,并开始新的研究方向。RCS奖还将使我能够扩大我的
进一步的合作研究,特别是与参与MVP的退伍军人管理局医生合作,
加强我的临床研究事业,并继续为科学界服务,
退伍军人事务部和更远的地方。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Maurizio Del Poeta其他文献
Maurizio Del Poeta的其他文献
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{{ truncateString('Maurizio Del Poeta', 18)}}的其他基金
10th International Conference on Cryptococcus and Cryptococcosis
第十届隐球菌和隐球菌病国际会议
- 批准号:
9343418 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Role of host sphingolipids against fungal infections
宿主鞘脂对抗真菌感染的作用
- 批准号:
10427149 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Role of host sphingolipids against fungal infections
宿主鞘脂对抗真菌感染的作用
- 批准号:
10554304 - 财政年份:2015
- 资助金额:
-- - 项目类别: