BLRD Research Career Scientist Award Application
BLRD 研究职业科学家奖申请
基本信息
- 批准号:10514630
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-10-01 至 2025-09-30
- 项目状态:未结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeAdrenal Cortex HormonesAnimal ModelAntifungal AgentsAntifungal TherapyAspergillus fumigatusAutoimmune DiseasesAwardBiological AssayBrainCD4 Positive T LymphocytesCandida albicansCell CountCellsCeramidesCessation of lifeClinicClinicalCollaborationsCommunicable DiseasesCommunitiesContainmentCryptococcal MeningitisCryptococcosisCryptococcusCryptococcus neoformansDependenceDevelopmentDiseaseDrug DesignDrug FormulationsDrug resistanceEducational process of instructingEffectivenessEnsureEnvironmentEnzymesExposure toFacultyFungal VaccinesGeneral PopulationGlucosylceramidesGoalsGranulomaGrowthHIVHandHost DefenseImmune EvasionImmune systemImmunityImmunocompromised HostIndustryInfectionInjectionsInositolIntegration Host FactorsInterventionInvestigationKnowledgeLaboratoriesLipidsLungMalignant NeoplasmsMediatingMedicalMedical centerMolecularMorbidity - disease rateMycosesOrgan TransplantationOrganismPathogenesisPathogenicityPathway interactionsPatientsPharmaceutical ChemistryPharmaceutical PreparationsPhenotypePhysiciansPopulationPostdoctoral FellowPredispositionPreventiveProcessResearchResearch PersonnelResistanceSPHK1 enzymeScientistServicesSourceSouth CarolinaSpecificitySphingolipidsSphingomyelinsSpinal CordStructureStudentsSubstance abuse problemSymptomsTechnologyTestingThe science of MycologyTherapeuticTherapeutic immunosuppressionToxic effectToxicologyTrainingUniversitiesVeteransVirulenceWorkcareerchemotherapycross reactivitydesignexperiencefungushigh throughput screeningimmunoregulationinhibitorinterestmicrobialmicroorganism interactionmilitary servicemortalitymultiple sclerosis treatmentnovelnovel therapeutic interventionnovel therapeuticsopportunistic pathogenpatient populationresearch and developmentsmall moleculesphingomyelin synthasesphingosine 1-phosphatetherapeutically effective
项目摘要
ABSTRACT
I am an Infectious Diseases physician-scientist with over 28 years of experience in medical mycology.
During my career, I have been working in the clinic and at the bench, teaching and training many
students, post-docs and junior faculty at Duke University, the Medical University of South Carolina,
and now at Stony Brook University and at the Northport VA Medical Center. My overall career goal is
to bring a new antifungal in the clinic, and I am closer than ever with MicroRid Technologies Inc., a
start-up company I co-founded for the research and development of new antifungal drugs.
My laboratory pioneered the studies on lipid-mediated infectious diseases. My lab and my co-workers
reached such a high visibility in this field that we are continuously contacted for consultant work by
investigators from all over the world for lipid analysis in their favorite organisms. My studies have
mostly focused on fungal infections, particularly invasive fungal infections, because they are on the
rise in our Veterans and in our non-Veterans populations. As we live longer thanks to many benefits of
chemo- and immunosuppressive-therapies and organ transplantations, we are also facing a rise of
invasive fungal infectious diseases. Current antifungals are either fungistatic, toxic, with narrow
spectrum of activity or they become resistant. New treatment strategies are needed. In addition to
develop a new class of antifungal agents, the studies in my laboratory are also crucial to the
understanding of the host mechanisms required for fungal containment versus fungal dissemination
and disease. For these studies, I partnered with many collaborators at the VA medical centers, at
various Universities, and at the industry setting, establishing fruitful and successful collaborations. The
VA RCS award will allow our group to continue this great work and will provide stability to fulfill the
current goals and to start new research directions. The RCS Award will also allow me to broaden my
collaborative research even further, particularly with the VA physicians involved in the MVP,
enhancing my research clinical enterprise, and to continue my service to the scientific community at
the VA and beyond.
摘要
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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Maurizio Del Poeta其他文献
Maurizio Del Poeta的其他文献
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{{ truncateString('Maurizio Del Poeta', 18)}}的其他基金
10th International Conference on Cryptococcus and Cryptococcosis
第十届隐球菌和隐球菌病国际会议
- 批准号:
9343418 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Role of host sphingolipids against fungal infections
宿主鞘脂对抗真菌感染的作用
- 批准号:
10427149 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Role of host sphingolipids against fungal infections
宿主鞘脂对抗真菌感染的作用
- 批准号:
10554304 - 财政年份:2015
- 资助金额:
-- - 项目类别: