10th International Conference on Cryptococcus and Cryptococcosis

摘要 该提案要求部分支持第10届国际隐球菌和隐球菌病会议 （ICCC）将于2017年3月26日至30日在巴西伊瓜苏举行。新型隐球菌是一种环境 在当今世界，这种微生物已成为越来越多的免疫功能低下患者的主要威胁。 最近，CDC估计全世界每年将有超过100万例新的隐球菌病病例发生在患者中， 与艾滋病，其中超过一半的人感染隐球菌病死亡的感染（1，2）。可怕的是，在此期间 在过去的几年里，隐球菌病已经出现在加拿大的温哥华岛（3，4）和太平洋西北部。 US（5-7）是免疫功能正常受试者的重要疾病。这些流行病学数据强调了 让这种真菌继续出现在意想不到的地理和临床环境中。 这次会议的广泛和长期目标是汇集世界领先的研究人员在这方面 迅速扩大的领域，以促进跨学科的讨论，研究和临床合作，以提高我们的 了解隐球菌和隐球菌病的致病机制。 这次会议的具体目标是召集其专门知识涵盖联合国系统内关键领域的主要专家， 这一领域，以及早期的职业生涯和初级研究人员，学生和博士后。我们预计将接待200名 参加这次会议。该计划将分为14个会议，涵盖不同的属性， 病原体的特性以及宿主的易感性和免疫力，强调是什么使一个正常的主机 突然对这种疾病易感重要的是，会议将充分报道当前和新的 治疗策略和一个特殊的论坛，以解决与不同的临床背景， 世界各地的临床医生都在操作。一般情况下，每次口头会议将包括4个演讲：3个演讲（20分钟） 随后是该领域领导人的5分钟讨论和从摘要中选择的1个演讲（10分钟）， 讨论初级研究人员、研究生和博士后研究员的摘要将包括在 被选中做口头陈述的人。会议将举办两次海报会议，让所有与会者 积极参与这些主题。不会有并发会话。我们将尽一切努力鼓励 研究生和博士后的参与，我们将看到妇女、少数民族和 残疾人。将根据需要提供托儿服务。 第10届ICCC意义重大，因为它关注的是一种重要的传染病， 免疫功能低下和免疫功能正常的人，汇集了国际研究的成员， 研究隐球菌病的人该应用程序的健康相关性是直接和转化的： 所产生的讨论和潜在的新合作也将确定重要的基础科学问题 为开发新的预防和治疗策略开辟新的途径。

ABSTRACT This proposal requests partial support for the 10th International Conference on Cryptococcus and Cryptococcosis (ICCC) to be held in Foz do Iguazu, Brazil, March 26-30, 2017. Cryptococcus neoformans is an environmental organism that has become a major threat to a growing number of immunocompromised patients in today's world. Recently, the CDC estimated more than 1 million new cases/year of cryptococcosis will occur worldwide in patients with AIDS, with more than half of those affected by cryptococcosis dying of the infection (1, 2). Frighteningly, during the last few years, cryptococcosis has emerged in the Vancouver Island, Canada (3, 4) and Pacific Northwest of the US (5-7) as an important disease in immunocompetent subjects. These epidemiological data underscore the potential for this fungus to continue to emerge in unexpected geographic and clinical settings. The broad and long-term goal of this conference is to bring together the world's leading researchers in this rapidly expanding field to foster cross-disciplinary discussions, research, and clinical collaborations to enhance our understanding of the mechanisms of pathogenicity of Cryptococcus and cryptococcosis. The specific aims of this meeting will be to convene leading experts whose expertise covers critical areas within this field, as well as early career and junior investigators, students, and postdocs. We anticipate hosting 200 participants for this conference. The program will be structured into 14 sessions covering the diverse properties and characteristics of the pathogen as well as host susceptibility and immunity, emphasizing what makes a normal host suddenly susceptible to this disease. Importantly, the Conference will provide ample coverage of current and novel therapeutic strategies and a special forum to address clinical issues related to diverse clinical backgrounds within which clinicians from around the world operate. In general, each oral session will consist of 4 talks: 3 talks (20 min) followed by a 5-min discussion by leaders in the field and 1 talk selected from the abstracts (10 min) with a 5-min discussion. Abstracts from junior investigators, graduate students, and postdoctoral fellows will be included among those selected for oral presentation. The Conference will host 2 poster sessions which will permit all participants to actively contribute to these topics. There will be no concurrent sessions. Every effort will be made to encourage participation by graduate students and postdocs and we will see parity with respect to women, minorities, and persons with disabilities. Childcare will be provided as needed. The 10th ICCC is significant because focuses on an important infectious disease afflicting both immunocompromised and immunocompetent people, bringing together members of the international research community who investigate cryptococcosis. The health relatedness of this application is immediate and translational: the discussions generated and potential new collaborations will define the important basic science questions as well as forge new avenues for the development of novel prevention and treatment strategies.