PULESA-UGANDA-Strengthening the Blood Pressure Care and Treatment cascade for Ugandans living with HIV-ImpLEmentation Strategies to SAve lives

PULESA-乌干达-加强乌干达艾滋病毒感染者的血压护理和治疗级联实施策略以拯救生命

• 批准号: 10508767
• 负责人: Chris Todd Longenecker
• 金额: $ 74.41万
• 依托单位: INFECTIOUS DISEASES RES COLLABORATION
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10508767
• 关键词: AIDS/HIV problem; Address; Adherence; Adoption; Africa South of the Sahara; Antihypertensive Agents; Awareness; Blood; Blood Pressure; Cardiovascular Diseases; Caring; Cessation of life; Chronic; Climate; Clinic; Clinical; Cluster randomized trial; Collaborations; Consolidated Framework for Implementation Research; Coronary; Cost Analysis; Cost Effectiveness Analysis; Cost effectiveness research; Data; Data Set; Development; Diagnosis; Diagnostic Equipment; Economics; Expenditure; Foundations; Goals; Gold; Government; Grant; HIV; HIV Infections; Health; Health Services; Heart; Household; Hybrids; Hypertension; Institution; International; Intervention; Investments; Knowledge; Low-Density Lipoproteins; Measurement; Methods; Modeling; Monitor; Patients; Persons; Pharmaceutical Preparations; Plant Roots; Prevention; Process; Randomized; Research Design; Resources; Risk; Service delivery model; Training; Uganda; Update; Use Effectiveness; Variant; Work; antiretroviral therapy; base; cardiovascular disorder risk; cardiovascular risk factor; comorbidity; compare effectiveness; cost; cost effective; cost effectiveness; cost-effectiveness evaluation; data format; design; disability; disability-adjusted life years; economic impact; effectiveness evaluation; effectiveness outcome; effectiveness testing; evidence base; formative assessment; human centered design; hypertension control; hypertensive; implementation cost; implementation framework; implementation outcomes; implementation science; implementation strategy; improved; incremental cost-effectiveness; innovation; low and middle-income countries; multidisciplinary; peer; peri-urban; preservation; prevent; primary outcome; process evaluation; screening; service delivery; therapy development; treatment as usual; uptake

Project Summary Chronic HIV infection is a well-established risk factor for cardiovascular disease. In sub-Saharan Africa)—a region that may account for half of the global burden of CVD attributable to HIV—hypertension is the most important driver of CVD risk. Profound barriers to effective hypertension management exist, including limited knowledge, inconsistent BP measurement, and poor access to medications. HIV care innovations such as access to no-cost antiretroviral therapy, differentiated service delivery and use of PLHIV peers in care models may improve care of comorbid conditions such as hypertension. The overarching goal of PULESA-UGANDA study is to improve the BP treatment cascade for people living with HIV (PLHIV) in urban and peri-urban Uganda in a scalable and sustainable manner. This hybrid IS Type 3 study proposes to first explore current practice, routines, barriers, and facilitators of evidence–based BP care in HIV clinical settings in Kampala and Wakiso districts (Aim 1). Then, using a human-centered design approach, a design team of key stakeholders will use data from the formative assessment to develop a multi-component implementation strategy (HTN-PLUS) to improve uptake and adherence to evidence-based BP treatments, contextually adapted to these Ugandan HIV clinics (Sub-aim 1.1). The design team will adapt differentiated service delivery models, use of hypertensive PLHIV peer champions, and methods of BP monitoring that address specific barriers and facilitators of BP care. In a stepped-wedge cluster randomized trial of 16 clinics from Kampala and Wakiso, we will determine the effectiveness of implementation strategies to improve BP cascade metrics (Aim 2). Clinics will be randomized to receive free and consistent access to diagnostic equipment and evidence-based antihypertensive drugs (HTN-BASIC) with and without the multi-component implementation strategy developed in sub-aim 1 (HTN-PLUS). The primary effectiveness outcome will be % of patients with hypertension diagnosis who are controlled (<140mmHg systolic). We hypothesize that the HTN-BASIC intervention will increase control from 25% at baseline to 35%, and that HTN-PLUS will further increase control to 40%. We will conduct an extensive mixed-methods process evaluation. We will assess scalability as our main implementation outcome, and will also assess acceptability, adoption, and implementation climate. Finally, we will evaluate the economic and financial sustainability of the integrated care strategies in a cost-effectiveness analysis from a societal perspective that will include household out-of-pocket expenditures. The primary outcome of this aim will be incremental cost per BP- controlled patient. This study will provide much needed evidence to SSA government stakeholders for a strategy to preserve the health gains of HIV treatment by preventing death and disability from CVD. Importantly, it will offer economic evidence of the scalability, sustainability, and equity of a model of HIV- hypertension management integration.

项目摘要 慢性艾滋病毒感染是心血管疾病的一个公认的危险因素。在撒哈拉以南非洲）-a 该地区可能占全球一半的心血管疾病负担归因于艾滋病毒高血压是最 CVD风险的重要驱动因素。有效的高血压管理存在深刻的障碍，包括有限的 知识，血压测量不一致，以及难以获得药物。艾滋病毒护理创新，如 获得免费抗逆转录病毒治疗、提供差别化服务以及在护理模式中使用艾滋病毒感染者同伴 可以改善对高血压等并发症的护理。普莱萨-乌干达的总体目标 一项研究旨在改善城市和城郊艾滋病毒感染者（PLHIV）的BP治疗级联 乌干达以可扩展和可持续的方式。这项混合IS 3型研究建议首先探索 HIV临床环境中循证BP护理的当前实践、常规、障碍和促进因素 在坎帕拉和Wakiso区（目标1）。然后，使用以人为本的设计方法， 主要利益相关者将利用形成性评估的数据， 实施战略（HTN-PLUS），以提高循证BP的吸收和依从性 根据乌干达这些艾滋病毒诊所的具体情况调整治疗方法（次级目标1.1）。设计团队会适应 差异化的服务提供模式，高血压PLHIV同行冠军的使用，以及BP方法 监测解决BP护理的具体障碍和促进因素。在一个随机的阶梯楔形群中， 我们将在坎帕拉和瓦基索的16个诊所进行试验，确定实施的有效性 改进BP级联度量的策略（目标2）。诊所将随机接受免费和 持续获得诊断设备和循证降压药物（HTN-BASIC）， 没有次级目标1（HTN-PLUS）中制定的多组成部分执行战略。主 有效性结果将是高血压诊断患者中控制（<140 mmHg）的百分比 收缩压）。我们假设HTN-BASIC干预将控制从基线的25%增加到35%， HTN-PLUS将进一步将控制提高到40%。我们将进行广泛的混合方法过程 评价我们将评估可扩展性作为我们的主要实施成果，还将评估可接受性， 通过和实施的气候。最后，我们将评估经济和财政的可持续性， 从社会角度进行成本效益分析的综合护理战略，包括 家庭自付支出。这一目标的主要结果将是每个BP的增量成本- 控制病人。这项研究将为SSA政府利益相关者提供急需的证据， 通过预防心血管疾病导致的死亡和残疾，保护艾滋病毒治疗的健康收益。 重要的是，它将提供经济证据，证明艾滋病毒模型的可扩展性、可持续性和公平性， 高血压管理一体化。