TBEL Admin Core

行政核心--摘要 行政核心(AC)将为三国提供所有行政和通信支持 胰腺癌TBEL(Tri-PACT)中心调查人员，并形成多产的中心“枢纽” NCI tbel社区内的互动。我们三公约中心提案的标题是“肿瘤” 微环境串扰导致胰腺癌的早期损害“，我们的中心包括三个 机构-UT MD Anderson癌症中心(UTMDACC)、密歇根大学(UMich)和约翰霍普金斯大学 大学(JHU)合作和整合的U54致力于研究早期胰腺肿瘤。三合一- Pact Center AC将由总体联系PI、Anirban Maitra博士和联合PI Marina Pasca di Magliano博士领导， 并被安置在UTMDACC的谢赫·艾哈迈德胰腺癌研究中心。空调将会是 由一名具有多名调查员拨款经验的博士级核心管理员提供支持。更进一步，余博士 UTMDACC生物统计学临时主席兼教授沈将提供全面的统计 为三方协定中心提供支助，并将由一名高级统计分析员协助。Maitra医生和AC已经 在监督和参与多名调查员资助方面拥有丰富的经验，其中包括 NCI U01、P01和P50资助金。咨询委员会的总体目标将是：(A)监测研究进展和 提供稳定和持续的领导力，以促进以下方面的集成、沟通和协作 参与三个拟议项目和共享资源核心的Tri-Pact中心调查人员 (多尺度计算肿瘤学研究核心或M-CORE)，以及(B)确保与 同时资助的其他Tbel U54站点和Tbel CDMC，通过正式和非正式合作 在Tbel保护伞下的努力。咨询委员会将利用两家公司广泛的研究专长 内部咨询委员会(IAB)和外部咨询委员会(EAB)在关键决策步骤中的作用 当前拟议项目的研究方向发生了变化。审计委员会将确保财政管理，包括 人员、预算和工作监督，有助于组织虚拟和面对面的正在进行的工作 为Tri-Pact中心调查人员举行会议，参与手稿准备，并提供联邦授权的 向NCI提交进展和其他报告。咨询委员会将协助私人侦查员和三地协定调查员出席会议。 参加半年一次的TBEL财团会议，并确保我们参与其他网络活动，包括 Tbel工作组、跨网络协作以及在Tbel内外传播成果 社区。协调委员会将作为TBEL CDMC的联络人，确保TriPACT中心的移交- 根据适当的转让协议生成的数据和材料。协调委员会还将确保及时 与NCI项目总监进行沟通和协商，以确定是否遵守或偏离规定 规划目标。最后但并非最不重要的一点是，AC还将提高对胰腺癌的早期认识 通过面向公众的网站和出版物在社区进行病变研究和宣传。

ADMINISTRATIVE CORE - Abstract The Administrative Core (AC) will provide all of the administrative and communications support to the Tri-State Pancreatic Adenocarcinoma TBEL (Tri-PACT) Center investigators, and form the central “hub” for productive interactions within the NCI TBEL community. The title of our Tri-PACT Center proposal is “Tumor Microenvironment Crosstalk Drives Early Lesions in Pancreatic Cancer”, and our Center incorporates three institutions – UT MD Anderson cancer Center (UTMDACC), University of Michigan (UMich) and Johns Hopkins University (JHU) in a collaborative and integrated U54 endeavor to study early pancreatic neoplasia. The Tri- PACT Center AC will be led by overall Contact PI, Dr. Anirban Maitra, and Co-PI Dr. Marina Pasca di Magliano, and housed within the Sheikh Ahmed Center for Pancreatic Cancer Research at UTMDACC. The AC will be supported by a PhD-level Core Administrator with experience with multi-investigator grants. Further, Dr. Yu Shen, Professor and Chair ad interim of Biostatistics at UTMDACC, will provide comprehensive statistical support for the Tri-PACT Center and will be assisted by a senior statistical analyst. Dr. Maitra and the AC have considerable experience in overseeing and participating in multi-investigator grants that include programmatic NCI U01, P01 and P50 Grants. The overall goals of the AC will be (a) to monitor research progress and to provide stable and continuous leadership that advances integration, communication, and collaboration among the Tri-PACT Center investigators participating in the three proposed projects and shared resource core (Multiscale Computational Oncology Research Core or M-CORE), and (b) to ensure productive interactions with other concurrently funded TBEL U54 sites and the TBEL CDMC, through formal and informal collaborative endeavors under the TBEL umbrella. The AC will leverage the wide-ranging research expertise of both the Internal Advisory Board (IAB) and the External Advisory Board (EAB) in critical decision-making steps, such as changes in research directions of currently proposed projects. The AC will ensure fiscal management, including personnel, budgets, and effort oversight, facilitate organization of virtual and in-person work-in-progress meetings for Tri-PACT center investigators, engage in manuscript preparation, and provide federally mandated progress and other reports to the NCI. The AC will facilitate attendance for the PIs and Tri-PACT investigators to the semi-annual TBEL consortium meetings, and ensure our participation in other network activities, including TBEL working groups, trans-network collaborations, and dissemination of results within and beyond the TBEL community. The AC will serve as a liaison with the TBEL CDMC in ensuring the transfer of TriPACT Center- generated data and materials under appropriate transfer agreements. The AC will also ensure timely communication and consultation with the NCI Program Directors for both adherence and deviations from stated programmatic goals. Last but not the least, the AC will also enhance awareness of pancreatic cancer early lesion research and advocacy in the community through public-facing websites and and publications.