TBEL Admin Core

行政核心-摘要 行政核心（AC）将为三国提供所有行政和通信支持。 胰腺癌TBEL（Tri-PACT）中心的研究人员，并形成了生产的中心“枢纽” NCI TBEL社区内的互动。我们的Tri-PACT中心提案的标题是“肿瘤 微环境串扰驱动胰腺癌的早期病变”，我们的中心包括三个 机构- UT MD安德森癌症中心（UTMDACC），密歇根大学（UMich）和约翰霍普金斯 在一个合作和综合的U 54奋进研究早期胰腺肿瘤。三- PACT中心AC将由总联系PI Anirban Maitra博士和Co-PI Marina Pasca di Magliano博士领导， 并被安置在UTMDACC的谢赫艾哈迈德胰腺癌研究中心。AC将 由一位具有多研究者赠款经验的博士级核心管理员提供支持。此外，Yu博士 沈教授，UTMDACC生物统计学临时主席，将提供全面的统计数据， 该办公室将为《打击跨国有组织犯罪公约》三方中心提供支助，并将由一名高级统计分析员提供协助。梅特拉医生和AC 在监督和参与包括方案在内的多名研究者赠款方面具有丰富的经验 NCI U 01、P01和P50赠款。咨询委员会的总体目标是：（a）监测研究进展， 提供稳定和持续的领导力，促进各部门之间的整合、沟通和协作 参与三个拟议项目和共享资源核心的Tri-PACT中心调查员 （多尺度计算肿瘤学研究核心或M-CORE），以及（B）确保与 通过正式和非正式的合作， 在TBL的保护伞下努力。AC将利用双方广泛的研究专业知识， 内部咨询委员会（IAB）和外部咨询委员会（EAB）在关键决策步骤，如 改变目前拟议项目的研究方向。审计委员会将确保财务管理，包括 人员、预算和工作监督，便于组织虚拟和面对面的在制品 为Tri-PACT中心研究者召开会议，参与手稿准备，并提供联邦授权的 向NCI提交进度报告和其他报告。AC将为PI和Tri-PACT研究者的出席提供便利 参加半年一次的TBEL联盟会议，并确保我们参与其他网络活动，包括 TBEL工作组、跨网络合作以及在TBEL内外传播成果 社区AC将作为TBEL CDMC的联络人，确保TriPACT中心的移交- 根据适当的转让协议生成数据和材料。AC还将确保及时 与NCI项目总监沟通和协商，以遵守和偏离所述 方案目标。最后但并非最不重要的是，AC还将提高对胰腺癌的早期认识 通过面向公众的网站和出版物在社区进行病变研究和宣传。

ADMINISTRATIVE CORE - Abstract The Administrative Core (AC) will provide all of the administrative and communications support to the Tri-State Pancreatic Adenocarcinoma TBEL (Tri-PACT) Center investigators, and form the central “hub” for productive interactions within the NCI TBEL community. The title of our Tri-PACT Center proposal is “Tumor Microenvironment Crosstalk Drives Early Lesions in Pancreatic Cancer”, and our Center incorporates three institutions – UT MD Anderson cancer Center (UTMDACC), University of Michigan (UMich) and Johns Hopkins University (JHU) in a collaborative and integrated U54 endeavor to study early pancreatic neoplasia. The Tri- PACT Center AC will be led by overall Contact PI, Dr. Anirban Maitra, and Co-PI Dr. Marina Pasca di Magliano, and housed within the Sheikh Ahmed Center for Pancreatic Cancer Research at UTMDACC. The AC will be supported by a PhD-level Core Administrator with experience with multi-investigator grants. Further, Dr. Yu Shen, Professor and Chair ad interim of Biostatistics at UTMDACC, will provide comprehensive statistical support for the Tri-PACT Center and will be assisted by a senior statistical analyst. Dr. Maitra and the AC have considerable experience in overseeing and participating in multi-investigator grants that include programmatic NCI U01, P01 and P50 Grants. The overall goals of the AC will be (a) to monitor research progress and to provide stable and continuous leadership that advances integration, communication, and collaboration among the Tri-PACT Center investigators participating in the three proposed projects and shared resource core (Multiscale Computational Oncology Research Core or M-CORE), and (b) to ensure productive interactions with other concurrently funded TBEL U54 sites and the TBEL CDMC, through formal and informal collaborative endeavors under the TBEL umbrella. The AC will leverage the wide-ranging research expertise of both the Internal Advisory Board (IAB) and the External Advisory Board (EAB) in critical decision-making steps, such as changes in research directions of currently proposed projects. The AC will ensure fiscal management, including personnel, budgets, and effort oversight, facilitate organization of virtual and in-person work-in-progress meetings for Tri-PACT center investigators, engage in manuscript preparation, and provide federally mandated progress and other reports to the NCI. The AC will facilitate attendance for the PIs and Tri-PACT investigators to the semi-annual TBEL consortium meetings, and ensure our participation in other network activities, including TBEL working groups, trans-network collaborations, and dissemination of results within and beyond the TBEL community. The AC will serve as a liaison with the TBEL CDMC in ensuring the transfer of TriPACT Center- generated data and materials under appropriate transfer agreements. The AC will also ensure timely communication and consultation with the NCI Program Directors for both adherence and deviations from stated programmatic goals. Last but not the least, the AC will also enhance awareness of pancreatic cancer early lesion research and advocacy in the community through public-facing websites and and publications.