Optical neural motes to enable high density recording through intact dura in a nonhuman primate

光学神经微粒可通过非人类灵长类动物的完整硬脑膜进行高密度记录

• 批准号: 10516965
• 负责人: David Blaauw
• 金额: $ 257.28万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-18 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10516965
• 关键词: Address; Animals; Architecture; Area; BRAIN initiative; Brain; Brain Diseases; Caliber; Cells; Chronic; Cicatrix; Clinical; Communication; Consumption; Country; Data; Devices; Dura Mater; Dust; Electrodes; Electronics; Encapsulated; Failure; Fiber; Fingers; Funding; Future; Generations; Glass; Goals; Hemorrhage; Implant; Injectable; Lead; Light; Link; Mechanics; Medical; Motor; Motor Cortex; Neurons; Neurosciences; Noise; Operative Surgical Procedures; Optics; Performance; Physics; Polymers; Positioning Attribute; Primates; Public Health; Rattus; Research; Rodent; Rodent Model; Scalp structure; Scheme; Silicon; Surface; System; Techniques; Testing; Thick; Time; Tissues; Utah; Validation; Width; Work; base; brain machine interface; brain tissue; carbon fiber; cold temperature; communication theory; cranium; data communication; data exchange; density; design; implantable device; implantation; improved; in vivo; innovation; integrated circuit; miniaturize; multidisciplinary; neural circuit; neuron loss; neurotransmission; nonhuman primate; novel therapeutics; operation; prevent; prototype; relating to nervous system; response; seal; tool; ultrasound; wireless; wireless implant

Project Summary / Abstract IR Powered and Hermetically-Sealed Single-Unit Neural Recording Wireless Motes for Large Scale Implantation Into Nonhuman Primate Cortex In this research agenda, we propose the ReMote which is a wireless neural recording probe that utilizes near-infrared (NIR) light for both power delivery and two-way communication, 8m diameter carbon fiber electrodes that can be implanted with minimal bleeding and scarring, a new circuit architecture based on extracting spiking band power (SBP) which reduces power consumption and the communication bandwidth but nonetheless detects single units, a physically unclonable function (PUF) for independent addressing of the motes after implantation, and miniature glass packaging for a long term hermetic circuit protection. The ReMote is < 250 m in width, sits on top of the cortex, and carbon fibers no larger than the neurons themselves penetrate into the brain. Aim 1 is focused on the design of the CMOS and optical components of the mote, with prototypes already in place and fully wireless operation demonstrated. Aim 2 is focused on packaging and functionalization of the carbon fiber electrode. Aim 3 is in vivo validation, starting on day one in rats with mechanically equivalent devices, progressing to chronic recording with active devices in rats, and then finally progressing to implantation of 1000 devices in n=2 nonhuman primates. We believe this will realize true neural recording dust for the first time and can be used for 1000+ channel wireless recording in primate cortex. It has the potential to revolutionize nonhuman primate neuroscience, making it standard practice to record thousands of channels across many cm of cortex.

项目总结/摘要 IR供电和密封的单单元神经记录无线 用于大规模植入非人灵长类动物皮层的微粒 在这项研究议程中，我们提出了ReMote，这是一种无线神经记录探头， 近红外（NIR）光，用于电力传输和双向通信，直径8微米的碳纤维 电极，可以植入最小的出血和疤痕，一种新的电路架构， 提取降低功耗和通信的尖峰频带功率（SBP 带宽，但仍然检测单个单元，物理不可克隆功能（PUF），用于独立 植入后微粒的寻址，以及用于长期密封电路的微型玻璃封装 保护ReMote的宽度小于250微米，位于皮质的顶部，碳纤维不大于 神经元本身会渗透到大脑中。目标1是重点设计的CMOS和光学 mote的组件，原型已经到位，完全无线操作演示。 目标2是碳纤维电极的包装和功能化。目标3是在体内 确认，从第一天开始，在大鼠中使用机械等同器械，进展至慢性 在大鼠中用有源装置记录，然后最后进展到植入1000个装置，n=2 非人类灵长类动物我们相信这将首次实现真正的神经记录尘埃，并且可以 用于灵长类动物皮层1000+通道无线记录。它有可能彻底改变 非人类灵长类神经科学，使其成为标准的做法，记录数千个渠道， 几厘米厚的皮层

项目成果

A Wireless Neural Stimulator IC for Cortical Visual Prosthesis.

用于皮质视觉假体的无线神经刺激器 IC。

• DOI: 10.23919/vlsitechnologyandcir57934.2023.10185375
• 发表时间: 2023
• 期刊: 2023 IEEE Symposium on VLSI Technology and Circuits
• 作者: Lee,Jungho;Letner,Joseph;Lim,Jongyup;Sun,Yi;Jeong,Seokhyeon;Kim,Yejoong;Koo,Beomseo;Atzeni,Gabriele;Liao,Jiawei;Richie,Julianna;Valle,ElenaDella;Patel,Paras;Jang,Taekwang;Chestek,Cynthia;Phillips,Jamie;Weiland,James;Sylves
• 通讯作者: Sylves