Optical neural motes to enable high density recording through intact dura in a nonhuman primate

光学神经微粒可通过非人类灵长类动物的完整硬脑膜进行高密度记录

• 批准号: 10516965
• 负责人: David Blaauw
• 金额: $ 257.28万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-18 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10516965
• 关键词: Address; Animals; Architecture; Area; BRAIN initiative; Brain; Brain Diseases; Caliber; Cells; Chronic; Cicatrix; Clinical; Communication; Consumption; Country; Data; Devices; Dura Mater; Dust; Electrodes; Electronics; Encapsulated; Failure; Fiber; Fingers; Funding; Future; Generations; Glass; Goals; Hemorrhage; Implant; Injectable; Lead; Light; Link; Mechanics; Medical; Motor; Motor Cortex; Neurons; Neurosciences; Noise; Operative Surgical Procedures; Optics; Performance; Physics; Polymers; Positioning Attribute; Primates; Public Health; Rattus; Research; Rodent; Rodent Model; Scalp structure; Scheme; Silicon; Surface; System; Techniques; Testing; Thick; Time; Tissues; Utah; Validation; Width; Work; base; brain machine interface; brain tissue; carbon fiber; cold temperature; communication theory; cranium; data communication; data exchange; density; design; implantable device; implantation; improved; in vivo; innovation; integrated circuit; miniaturize; multidisciplinary; neural circuit; neuron loss; neurotransmission; nonhuman primate; novel therapeutics; operation; prevent; prototype; relating to nervous system; response; seal; tool; ultrasound; wireless; wireless implant

Project Summary / Abstract IR Powered and Hermetically-Sealed Single-Unit Neural Recording Wireless Motes for Large Scale Implantation Into Nonhuman Primate Cortex In this research agenda, we propose the ReMote which is a wireless neural recording probe that utilizes near-infrared (NIR) light for both power delivery and two-way communication, 8m diameter carbon fiber electrodes that can be implanted with minimal bleeding and scarring, a new circuit architecture based on extracting spiking band power (SBP) which reduces power consumption and the communication bandwidth but nonetheless detects single units, a physically unclonable function (PUF) for independent addressing of the motes after implantation, and miniature glass packaging for a long term hermetic circuit protection. The ReMote is < 250 m in width, sits on top of the cortex, and carbon fibers no larger than the neurons themselves penetrate into the brain. Aim 1 is focused on the design of the CMOS and optical components of the mote, with prototypes already in place and fully wireless operation demonstrated. Aim 2 is focused on packaging and functionalization of the carbon fiber electrode. Aim 3 is in vivo validation, starting on day one in rats with mechanically equivalent devices, progressing to chronic recording with active devices in rats, and then finally progressing to implantation of 1000 devices in n=2 nonhuman primates. We believe this will realize true neural recording dust for the first time and can be used for 1000+ channel wireless recording in primate cortex. It has the potential to revolutionize nonhuman primate neuroscience, making it standard practice to record thousands of channels across many cm of cortex.

项目摘要/摘要

项目成果

A Wireless Neural Stimulator IC for Cortical Visual Prosthesis.

用于皮质视觉假体的无线神经刺激器 IC。

• DOI: 10.23919/vlsitechnologyandcir57934.2023.10185375
• 发表时间: 2023
• 期刊: 2023 IEEE Symposium on VLSI Technology and Circuits
• 作者: Lee,Jungho;Letner,Joseph;Lim,Jongyup;Sun,Yi;Jeong,Seokhyeon;Kim,Yejoong;Koo,Beomseo;Atzeni,Gabriele;Liao,Jiawei;Richie,Julianna;Valle,ElenaDella;Patel,Paras;Jang,Taekwang;Chestek,Cynthia;Phillips,Jamie;Weiland,James;Sylves
• 通讯作者: Sylves