Optical neural motes to enable high density recording through intact dura in a nonhuman primate

项目摘要/摘要

Project Summary / Abstract IR Powered and Hermetically-Sealed Single-Unit Neural Recording Wireless Motes for Large Scale Implantation Into Nonhuman Primate Cortex In this research agenda, we propose the ReMote which is a wireless neural recording probe that utilizes near-infrared (NIR) light for both power delivery and two-way communication, 8m diameter carbon fiber electrodes that can be implanted with minimal bleeding and scarring, a new circuit architecture based on extracting spiking band power (SBP) which reduces power consumption and the communication bandwidth but nonetheless detects single units, a physically unclonable function (PUF) for independent addressing of the motes after implantation, and miniature glass packaging for a long term hermetic circuit protection. The ReMote is < 250 m in width, sits on top of the cortex, and carbon fibers no larger than the neurons themselves penetrate into the brain. Aim 1 is focused on the design of the CMOS and optical components of the mote, with prototypes already in place and fully wireless operation demonstrated. Aim 2 is focused on packaging and functionalization of the carbon fiber electrode. Aim 3 is in vivo validation, starting on day one in rats with mechanically equivalent devices, progressing to chronic recording with active devices in rats, and then finally progressing to implantation of 1000 devices in n=2 nonhuman primates. We believe this will realize true neural recording dust for the first time and can be used for 1000+ channel wireless recording in primate cortex. It has the potential to revolutionize nonhuman primate neuroscience, making it standard practice to record thousands of channels across many cm of cortex.