Optical neural motes to enable high density recording through intact dura in a nonhuman primate

项目摘要/摘要 红外供电和密封的单单元神经记录无线 用于大规模植入非人灵长类皮质的微粒 在本研究议程中，我们提出了一种无线神经记录探头Remote，它利用 用于电力传输和双向通信的近红外线(NIR)灯，直径8m碳纤维 可以植入的电极，出血和结疤最少，一种基于 提取尖峰频段功率(SBP)，降低功耗和通信 带宽，但仍然检测单个单元，物理上不可克隆的功能(PUF)用于独立 植入后微尘的寻址，以及用于长期密封电路的微型玻璃封装 保护。遥控器的宽度为250m，位于皮质顶部，碳纤维不超过 神经元本身渗透到大脑中。目标1专注于cmos和光学器件的设计。 尘埃的组成部分，原型已经到位，并展示了完全的无线操作。 目标2的重点是碳纤维电极的封装和功能化。AIM 3在体内 在使用机械等效装置的大鼠中，验证从第一天开始，进展到慢性 大鼠主动记录，最后植入1000个装置，n=2 非人灵长类动物。我们相信这将首次实现真正的神经记录粉尘，并可以 用于灵长类皮质1000多路无线记录。它具有革命性的潜力 非人灵长类神经科学，使记录数千个通道成为标准做法 许多厘米的皮质。

Project Summary / Abstract IR Powered and Hermetically-Sealed Single-Unit Neural Recording Wireless Motes for Large Scale Implantation Into Nonhuman Primate Cortex In this research agenda, we propose the ReMote which is a wireless neural recording probe that utilizes near-infrared (NIR) light for both power delivery and two-way communication, 8m diameter carbon fiber electrodes that can be implanted with minimal bleeding and scarring, a new circuit architecture based on extracting spiking band power (SBP) which reduces power consumption and the communication bandwidth but nonetheless detects single units, a physically unclonable function (PUF) for independent addressing of the motes after implantation, and miniature glass packaging for a long term hermetic circuit protection. The ReMote is < 250 m in width, sits on top of the cortex, and carbon fibers no larger than the neurons themselves penetrate into the brain. Aim 1 is focused on the design of the CMOS and optical components of the mote, with prototypes already in place and fully wireless operation demonstrated. Aim 2 is focused on packaging and functionalization of the carbon fiber electrode. Aim 3 is in vivo validation, starting on day one in rats with mechanically equivalent devices, progressing to chronic recording with active devices in rats, and then finally progressing to implantation of 1000 devices in n=2 nonhuman primates. We believe this will realize true neural recording dust for the first time and can be used for 1000+ channel wireless recording in primate cortex. It has the potential to revolutionize nonhuman primate neuroscience, making it standard practice to record thousands of channels across many cm of cortex.