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Evaluating EEG as a diagnostic and prognostic biomarker in Malawian children with febrile coma

评估脑电图作为马拉维热昏迷儿童的诊断和预后生物标志物

基本信息

批准号：
10523296
负责人：
Douglas Postels
金额：
$ 9.1万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-15 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10523296
关键词：
Acute Address Admission activity Africa African Area Blood Brain Edema Cerebral Ischemia Cerebral Malaria Cerebrum Cessation of life Child Child Care Childhood Clinical Coma Complement Computer software Country Critical Illness Data Diagnostic tests Diffuse Disease Electroencephalography Encephalitis Encephalopathies Enrollment Erythrocytes Etiology Fever Goals Hospitals Human Intervention Investigation Laboratories Malaria Malawi Meningitis Methods Modality Non-Convulsive Status Epilepticus Observational Study Outcome Parasitemia Parasites Pathogenesis Patient Care Patients Pattern Plasmodium Prognostic Marker Research Resources Role Seizures Sepsis Source Status Epilepticus Symptoms Time Viral Encephalitis adverse outcome brain magnetic resonance imaging clinical care clinical diagnosis co-infection comorbidity diagnostic biomarker high risk malaria infection malaria transmission outcome prediction research study respiratory venule

项目摘要

Abstract Coma with fever is a common clinical presentation for children living in resource-limited countries. In endemic areas, malaria is the most common cause. We previously established that EEG is a prognostic biomarker in pediatric cerebral malaria (CM). In this research, we will use data previously collected as part of an observational study enrolling Malawian children with non-malarial coma to identify if EEG is a diagnostic and prognostic biomarker in this patient group. We will evaluate whether there are differences in EEG studies in children with non-malarial coma and CM (a diagnostic biomarker). We will evaluate if there are EEG factors associated with hospital discharge outcomes in children with non-malarial febrile coma (a prognostic biomarker), as we did in our previous studies from children with CM. If EEG factors are associated with outcomes in children with non-malarial coma, we will compare them to the EEG factors associated with outcomes in children with CM. The results of this research may allow better clinical care of children with febrile coma, as it may help determine if the underlying cause of illness is malaria or non-malarial. It may help determine, at the time of admission, if a child with non-malarial coma is at higher risk of an adverse outcome.

摘要发烧昏迷是生活在资源有限国家的儿童的常见临床表现。地方病流行在一些地区，疟疾是最常见的原因。我们先前证实，脑电是一种预后生物标志物。儿童脑疟疾(CM)。在这项研究中，我们将使用之前收集的数据作为招募患有非疟疾昏迷的马拉维儿童进行观察性研究，以确定EEG是否是一种诊断和此患者组的预后生物标记物。我们将评估在EEG研究中是否存在差异儿童非疟疾昏迷和CM(一种诊断生物标志物)。我们会评估是否有脑电因素与非疟疾发热昏迷儿童的出院结果相关(预后因素生物标记物)，就像我们在之前对CM儿童的研究中所做的那样。如果脑电因素与非疟疾昏迷儿童的预后，我们将把它们与与以下因素相关的脑电因素进行比较慢性心肌炎患儿的预后。这项研究的结果可能会为发热儿童提供更好的临床护理。昏迷，因为这可能有助于确定疾病的根本原因是疟疾还是非疟疾。这可能会有帮助在入院时确定患有非疟疾昏迷的儿童是否有较高的不良结局风险。