SCISIPBIO: Understanding and Assembling Dream Teams to Conduct Clinical and Translational Science

SCISIPBIO：了解和组建开展临床和转化科学的梦之队

• 批准号: 10529291
• 负责人: Alina Ionica Lungeanu
• 金额: --
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10529291
• 关键词: Applications Grants; Automobile Driving; Biomedical Research; Clinical; Clinical Sciences; Collaborations; Development; Discipline; Dreams; Education; Effectiveness; Funding; Funding Agency; Future; Goals; Grant; Healthcare; Individual; Institution; Investments; Ontology; Pattern; Performance; Pilot Projects; Policy Maker; Procedures; Process; Productivity; Recommendation; Reporting; Research; Research Personnel; Research Project Grants; Science; Source; System; Time; Translational Research; Underrepresented Minority; United States National Institutes of Health; Vision; biomedical scientist; career; cost; demographics; design; human capital; improved; insight; novel; programs; success; tool

We hail individual geniuses, but success in science comes through collaboration (Farrar, 2017)." Biomedical breakthroughs come from collaboration that crosses boundaries. Boundaries created by disciplines, organizations, cultures, professions, and demographics. While cross-boundary collaboration in team science has demonstrated benefits, research also suggests they are unlikely to form, and when they do, are prone to coordination costs (Cooke & Hilton, 2015). This research project advances the Science of Team Science by "understanding" and "assembling" cross-boundary teams to conduct clinical and translational science. This research enables scholars and policymakers to design and assess "dream teams." Toward the aim of understanding, we conduct archival studies of NIH's Clinical & Translational Science Pilot Grant programs at two institutions to reveal the team assembly factors that drive formation and success. Toward the aim of assembling, we leverage a newly developed team recommender system. The fundamental goal is to generate recommendations to shift the composition of teams submitting Pilot Grant applications in particular and cross-boundary scientific teams in general. Insights from this project come at a critical point in time, when cross-boundary science is essential for biomedical research. Toward that aim, this project has two key sources of intellectual merit. First, the research advances the science of team science (Cooke & Hilton, 2015), answering calls to better understand the multilevel determinants of science team success. How are they forming and which ones are performing? Following teams from formation to maturity provide a holistic understanding of the factors driving team formation and performance. Knowing how to better assemble scientific teams has the potential to improve the career productivity of a major source of human capital, and to hasten breakthroughs in biomedical research. Furthermore, not all cross-boundary teams are successful. Previous research provides competing advice for those assembling teams. On the one hand, cross- boundary teams are most likely to produce novel insights (Stvilia et al., 2011; Uzzi et al., 2013), but they are also most likely to suffer process losses from their coordination costs (Cummings & Kiesler, 2007; Cummings et al., 2013). This large scale analysis will allow us to discover patterns that differentiate the kinds of cross-boundary teams who are ultimately successful from those who are not. The second source of intellectual merit is the development of a team recommender system for biomedical scientists to use to assemble cross-boundary teams for Pilot Projects. The Dream Team Builder was specifically mentioned in the NAS report as it builds on NIH-funded VIVO's ontology. We extend this tool to provide team recommendations, and study their effects on team assembly and future performance.

我们欢呼个别天才，但科学的成功来自合作 （Farrar，2017）。“生物医学的突破来自于跨越国界的合作。创建的边界 学科、组织、文化、职业和人口统计。团队中的跨界协作 科学已经证明了这些好处，研究还表明，它们不太可能形成，当它们形成时， 协调成本（Cooke &希尔顿，2015年）。该研究项目通过以下方式推进团队科学 “理解”和“组装”跨界团队进行临床和转化科学。本研究 使学者和决策者能够设计和评估“梦之队”。“为了理解的目的，我们 在两个机构对NIH的临床和转化科学试点资助计划进行档案研究，以揭示 推动形成和成功的团队组装因素。为了达到组装的目的，我们利用一个新的 开发团队推荐系统。基本目标是生成改变组成的建议 特别是提交试验拨款申请的团队，以及一般的跨界科学团队。 这个项目的见解来自一个关键的时间点，当跨界科学对生物医学至关重要时， research.为了实现这一目标，这个项目有两个关键的知识价值来源。首先，研究推进了 团队科学的科学（库克和希尔顿，2015年），接听电话，以更好地了解多层次的决定因素， 科学团队的成功它们是如何形成的，哪些在发挥作用？从编队到 成熟度提供了对推动团队形成和绩效的因素的全面理解。知道如何 更好地组合科学团队有可能提高人力资源的主要来源的职业生产力 资本，并加速生物医学研究的突破。此外，并非所有跨境队伍均 成功以前的研究为那些组建团队的人提供了竞争性的建议。一方面，交叉- 边界团队最有可能产生新颖的见解（Stvilia等人，2011; Uzzi等人，2013年），但也 最有可能遭受协调成本的过程损失（Cummings & Kiesler，2007; Cummings等人， 2013年）。这种大规模的分析将使我们能够发现区分跨界团队类型的模式 那些最终成功的人和那些失败的人。智力价值的第二个来源是发展一种 团队推荐系统，供生物医学科学家用于为试点项目组建跨境团队。的 梦之队建设者在NAS报告中特别提到，因为它建立在NIH资助的VIVO本体论的基础上。我们 扩展此工具以提供团队建议，并研究其对团队组合和未来绩效的影响。