Reinvigorating HIV Prevention and Care for People Who Use Drugs: Accelerating Progress and Sustaining Gains in the Midst of Societal Disruption

项目摘要/摘要-传染病流行病学和社会行为理论核心 传染病流行病学和社会行为理论核心(IDEST)的总体目标是 支持和培训CDUHR调查人员应用有关多层次因素的理论和知识，包括 当前正在影响艾滋病毒传播、自然历史、预防和 临床护理，以便他们准备开发和进行严格的高影响研究， 为结束吸毒者中的艾滋病毒作出贡献(PWUD)。(我们指的是这些大规模的破坏性 趋势和事件，如大事件和大趋势(BE/BT)。最近新的艾滋病病毒又卷土重来。 美国和国外的PWUD感染和暴发，在许多情况下，新冠肺炎大流行 已经造成了导致这些疫情爆发的相同情况。这表明有必要重振经济。 艾滋病毒研究议程。 IDEST核心有以下具体目标：1)鼓励和支持CDUHR调查人员申请 以及整合关于物质使用和艾滋病毒流行病学、预防和治疗的知识和理论 加强现有研究，开发和开展新的临床、社会行为和流行病学研究 将有助于在PWUD中终止艾滋病毒的研究；2)提供关于多层次因素的培训，以促进 或在社会动荡的背景下阻碍结束艾滋病毒，导致研究将这些因素纳入 帐户；以及3)领导实地指导广泛的研究和培训议程，制定和 传播相关的现有和新的跨学科理论和框架，重点是多层次 以及一般的时变考虑因素，特别是BE/BT。 核心成员是艾滋病毒感染和艾滋病毒的流行病学、预防、护理和治疗方面的专家- 相关的合并症、合并感染和并发症；在物质使用方面的研究包括 物质使用障碍和减少危害；以及在相关理论和小说的开发和使用中， 以理论为基础的指标。所有核心成员在现场和中心内都取得了很高的生产力。这个 CORE将提供培训和咨询，并将在中心内带头带来新兴的、 在流行病学、生物医学和临床方面的科学相关问题、新理论和进展 向CDUHR调查人员提供艾滋病毒和药物使用情况，重点是新的和早期的调查人员(新的/ESI) 调查人员的代表性不足。IDEST核心将与其他核心和中心领导层合作 支持CDUHR调查人员开发创新的高影响力研究，从而产生新的知识 与推动PWUD中HIV感染的多层次因素相关，以指导干预和政策促进 在消除艾滋病毒方面取得进展。

Project Summary/Abstract – Infectious Disease Epidemiology and Social-Behavioral Theory Core The overarching goal of the Infectious Disease Epidemiology and Social-Behavioral Theory Core (IDEST) is to support and train CDUHR investigators to apply theories and knowledge about multilevel factors, including current large-scale trends and events that are affecting HIV transmission, natural history, prevention, and clinical care, so that they are prepared to develop and carry out rigorous high-impact research that will contribute to ending HIV among people who use drugs (PWUD). (We refer to these large-scale disruptive trends and events as Big Events and Big Trends (BE/BT).) There has been a recent resurgence in new HIV infections and outbreaks among PWUD in the US and abroad, and, in many settings, the COVID-19 pandemic has generated the same circumstances that led to those outbreaks. This signals the need for a reinvigorated HIV research agenda. The IDEST Core has the following Specific Aims: 1) Encourage and support CDUHR investigators in applying and integrating knowledge and theory about substance use and HIV epidemiology, prevention, and treatment to enhance current studies and to develop and conduct new clinical, social-behavioral, and epidemiologic research that will contribute to ending HIV in PWUD; 2) Provide training on multilevel factors that may promote or impede ending HIV in the context of societal disruption, leading to studies that take these factors into account; and 3) Lead the field in guiding a broad research and training agenda by developing and disseminating relevant existing and new transdisciplinary theories and frameworks, with a focus on multilevel and time-varying considerations generally and BE/BT in particular. Core members are experts in the epidemiology, prevention, care and treatment of HIV infection and HIV- related related co-morbidities, co-infections, and complications; in the study of substance use including substance use disorders, and harm reduction; and in the development and use of relevant theories and novel, theory-based metrics. All Core members have been highly productive in the field and within the Center. The Core will provide training and consultation, and will take the lead within the Center on bringing emerging, scientifically relevant issues, new theories, and advances in epidemiologic, biomedical and clinical aspects of HIV and substance use to CDUHR investigators, with a focus on new and early stage investigators (new/ESI) and underrepresented investigators. The IDEST Core will collaborate with other Cores and Center Leadership to support CDUHR investigators to develop innovative high impact studies which will lead to new knowledge related to the multilevel factors driving HIV among PWUD to guide interventions and policies promoting progress toward eliminating HIV.