The Influence of Vocal Loading Upon the Healing of Experimental Vocal Fold Injury

项目摘要 发展和保持说话和唱歌的基本频率，同时也达到声音清晰度 是重要的公共卫生问题。发音困难的症状是最常见的沟通 紊乱目前还没有治疗方法来恢复原生声带固有层组成或喉部运动 伤后研究是有限的，因为没有体内模型喉损伤，表达的声音行为，可以 作为可靠的表型标记。一般来说，如果动物模型的行为可以作为标记， 影响复杂行为的病理学的发病或时间进程。具体来说，动物的可用性 一种结合了实验和遗传可及性与人类发声重要相似性的模型， 允许更强的推论。在这里，我们建议（1）量化关键解剖特征的发音器官在出生后 在一个新的模型中发展，和（2）描述实验性声带损伤后伤口愈合的时间过程， 一种声音剂量依赖的方式。结果将被集成在一个计算声带模型。完成这项工作 将为研究发声疾病机制和治疗开发提供新的小鼠模型。它 也将告知声带愈合过程中的声音占用的作用。

Project Summary The development and maintenance of a speaking and singing fundamental frequency, while also achieving vocal clarity throughout life, are important public health concerns. Symptoms of dysphonia are among the most common communication disorders. Currently there is no treatment to restore a native vocal fold lamina propria composition or laryngeal movements after injury. Research is limited because there is no in vivo model for larynx injuries that express a vocal behavior that can serve as a reliable phenotypic marker. In general, an animal model can benefit research if its behavior can serve as marker for the onset or the time-course of a pathology affecting a complex behavior. Specifically, the availability of an animal model that combines experimental and genetic accessibility with important similarities to human voice production could allow stronger inferences. Here we propose (1) to quantify key anatomical features of the vocal organ during postnatal developmental in a new model, and (2) to describe the time-course of wound healing after experimental vocal fold injury in a vocal dose- dependent fashion. Results will be integrated in a computational vocal fold model. Completion of this work will provide the field with a new mouse model for the study of vocal disease mechanisms and therapeutic development. It will also inform the role of vocal occupancy on the healing process of vocal folds.