The Influence of Vocal Loading Upon the Healing of Experimental Vocal Fold Injury

项目摘要 发展和保持说话和唱歌的基本频率，同时也实现声音清晰度 在整个生命过程中，都是重要的公共卫生问题。发音困难的症状是最常见的交流方式之一 精神错乱。目前还没有治疗方法来恢复天然声带固有层成分或喉部运动。 受伤后。研究是有限的，因为目前还没有喉部损伤的体内模型来表达发声行为 可作为可靠的表型标记。一般说来，如果动物模型的行为可以作为标记物，那么它对研究是有益的。 对于影响复杂行为的病理的开始或时间过程。具体地说，动物的可用性 将实验和遗传可及性与人类发声有重要相似之处的模型可能 允许更有力的推论。在这里，我们建议(1)量化出生后发声器官的主要解剖特征 (2)描述实验性声带损伤后创面愈合的时间进程。 一种依赖于剂量的发声方式。结果将被整合到计算声带模型中。完成这项工作 将为该领域研究发声疾病的发病机制和治疗发展提供一种新的小鼠模型。它 也将告知声带占用在声带愈合过程中的作用。

Project Summary The development and maintenance of a speaking and singing fundamental frequency, while also achieving vocal clarity throughout life, are important public health concerns. Symptoms of dysphonia are among the most common communication disorders. Currently there is no treatment to restore a native vocal fold lamina propria composition or laryngeal movements after injury. Research is limited because there is no in vivo model for larynx injuries that express a vocal behavior that can serve as a reliable phenotypic marker. In general, an animal model can benefit research if its behavior can serve as marker for the onset or the time-course of a pathology affecting a complex behavior. Specifically, the availability of an animal model that combines experimental and genetic accessibility with important similarities to human voice production could allow stronger inferences. Here we propose (1) to quantify key anatomical features of the vocal organ during postnatal developmental in a new model, and (2) to describe the time-course of wound healing after experimental vocal fold injury in a vocal dose- dependent fashion. Results will be integrated in a computational vocal fold model. Completion of this work will provide the field with a new mouse model for the study of vocal disease mechanisms and therapeutic development. It will also inform the role of vocal occupancy on the healing process of vocal folds.