2022 Chemistry and Biology of Tetrapyrroles Gordon Research Conference

项目摘要 四吡咯戈登研究会议（GRC）的化学和生物学是最大和最广泛的 国际会议，分享和讨论四吡咯的最新研究，一个多样化的蛋白质组 辅因子和代谢物，包括血红素、钴胺素（维生素B12）、叶绿素和胆色素。四吡咯 作为重要的辅助因子来控制对正常稳态重要的基本细胞过程， 发展此外，四吡咯还作为营养源和重要的信号和调节 正常和疾病状态下的分子对人类健康具有广泛的影响。本次会议作为 第一次会议提出新的未发表的四吡咯相关的研究成果;收集国际 各种级别的科学家，包括高级科学家和早期研究人员（ESI）以及 正式和非正式的环境，以创造新的联系和合作，以促进化学和 四吡咯的生物学;并为不同科学家的发展提供和促进包容性的环境 在公平和开放的环境中。 2022年GRC会议将于2022年7月17日至22日在罗德岛州纽波特的Salve Regina大学举行。的 四吡咯的化学和生物学GRC是国际和多样化观众的一种 它所吸引的。广泛多样的主题包括临床，生物和化学方面的四吡咯。在 此外，生物体的范围同样广泛，从细菌到人类。2022年GRC将 整合不同层次研究人员在以下领域的研究成果： 四吡咯的研究技术;血红素的运输、信号传导和调节;胆色素的许多方面; 四吡咯在人类健康和疾病中的作用;四吡咯的生物学; B12的多面性;调控 和叶绿素色素的生物合成;以及微生物四吡咯代谢。考虑到这些关键角色， 四吡咯在感染性疾病发病机制、宿主免疫、正常细胞发育 代谢，了解四吡咯的合成，调节，降解和运输对于 人体健康

PROJECT SUMMARY The Chemistry and Biology of Tetrapyrroles Gordon Research Conference (GRC) is the largest and broadest international meeting for sharing and discussing the latest research on tetrapyrroles, a diverse group of protein cofactors and metabolites which include heme, cobalamin (vitamin B12), chlorophyll, and bilins. Tetrapyrroles serve as important cofactors to control essential cellular processes important for normal homeostasis and development. In addition, tetrapyrroles also serve as a nutrient source and important signaling and regulatory molecules in normal and disease states with broad implication on human health. This meeting serves as the premier conference to present new unpublished tetrapyrrole related research findings; gather international scientists at a variety of levels including senior scientists with early stage investigators (ESI) and trainees in both formal and informal environments to create new connections and collaborations to advance the chemistry and biology of tetrapyrroles; and provide and foster an inclusive environment for the development of diverse scientists in an equitable and open setting. The 2022 GRC meeting will be held from July 17 - 22, 2022 at Salve Regina University in Newport, RI. The Chemistry & Biology of Tetrapyrroles GRC is one of a kind in terms of the international and diverse audience that it attracts. The broad diversity of topics include clinical, biological, and chemical aspects of tetrapyrroles. In addition, the range of organisms is equally as broad and spans from bacteria to humans. The 2022 GRC will integrate research from a variety of researchers at different levels in the following areas: new structural techniques to study tetrapyrroles; trafficking, signaling and regulation by heme; the many facets of bilins; tetrapyrroles in human health and disease; the biology of tetrapyrroles; the many faces of B12; the regulation and biosynthesis of chlorophyll pigments; and microbial tetrapyrrole metabolism. Given the critical roles that tetrapyrroles play in pathogenesis of infectious disease, host immunity, normal cellular development and metabolism, understanding the synthesis, regulation, degradation, and trafficking of tetrapyrroles is crucial for human health.