2022 Chemistry and Biology of Tetrapyrroles Gordon Research Conference

项目总结 四角化学和生物学戈登研究会议(GRC)是规模最大、范围最广的 国际会议，分享和讨论四个角色，一个不同的蛋白质基团的最新研究 辅因子和代谢物，包括血红素、钴胺(维生素B12)、叶绿素和胆红素。四聚吡咯 作为控制基本细胞过程的重要辅助因子，这些过程对正常的动态平衡和 发展。此外，四聚吡咯也是一种营养来源和重要的信号和调节。 正常和疾病状态下的分子对人类健康有着广泛的影响。本次会议作为 总理会议提出新的未发表的四吡咯相关研究成果；收集国际 不同级别的科学家，包括具有早期调查人员(ESI)的资深科学家和这两个领域的实习生 正式和非正式的环境，以创建新的联系和合作，以促进化学和 四个角色的生物学；为不同科学家的发展提供和培育一个包容各方的环境 在公平和开放的环境中。 2022年全球资源中心会议将于2022年7月17日至22日在密苏里州纽波特的萨尔维里贾纳大学举行。这个 四个角色的化学和生物学GRC是国际上和多样化的受众中的一员 它吸引人的地方。主题的广泛多样性包括四吡咯的临床、生物和化学方面。在……里面 此外，生物体的范围也同样广泛，从细菌到人类。2022年GRC将 综合不同层次不同研究人员在以下领域的研究：新结构 研究四吡咯的技术；运输、信号和由血红素调节；胆红素的许多方面； 四吡咯与人类健康和疾病；四吡咯的生物学；B12的多面性；调节 和叶绿素色素的生物合成；以及微生物的四吡咯代谢。考虑到关键角色， 四聚吡咯在传染病的发病机制、宿主免疫、正常的细胞发育和 新陈代谢，了解四聚吡咯的合成、调节、降解和运输对于 人类健康。

PROJECT SUMMARY The Chemistry and Biology of Tetrapyrroles Gordon Research Conference (GRC) is the largest and broadest international meeting for sharing and discussing the latest research on tetrapyrroles, a diverse group of protein cofactors and metabolites which include heme, cobalamin (vitamin B12), chlorophyll, and bilins. Tetrapyrroles serve as important cofactors to control essential cellular processes important for normal homeostasis and development. In addition, tetrapyrroles also serve as a nutrient source and important signaling and regulatory molecules in normal and disease states with broad implication on human health. This meeting serves as the premier conference to present new unpublished tetrapyrrole related research findings; gather international scientists at a variety of levels including senior scientists with early stage investigators (ESI) and trainees in both formal and informal environments to create new connections and collaborations to advance the chemistry and biology of tetrapyrroles; and provide and foster an inclusive environment for the development of diverse scientists in an equitable and open setting. The 2022 GRC meeting will be held from July 17 - 22, 2022 at Salve Regina University in Newport, RI. The Chemistry & Biology of Tetrapyrroles GRC is one of a kind in terms of the international and diverse audience that it attracts. The broad diversity of topics include clinical, biological, and chemical aspects of tetrapyrroles. In addition, the range of organisms is equally as broad and spans from bacteria to humans. The 2022 GRC will integrate research from a variety of researchers at different levels in the following areas: new structural techniques to study tetrapyrroles; trafficking, signaling and regulation by heme; the many facets of bilins; tetrapyrroles in human health and disease; the biology of tetrapyrroles; the many faces of B12; the regulation and biosynthesis of chlorophyll pigments; and microbial tetrapyrrole metabolism. Given the critical roles that tetrapyrroles play in pathogenesis of infectious disease, host immunity, normal cellular development and metabolism, understanding the synthesis, regulation, degradation, and trafficking of tetrapyrroles is crucial for human health.