Acquisition of Individually Ventilated Cage Rack Systems for the University of Mississippi Vivarium

项目摘要 利用单独通风的笼子系统(IVCs)安置啮齿动物已成为 生物医学研究领域的行业标准。社会性的综合方法 将啮齿动物安置在滤网顶部、空气交换率受到严格控制的微型隔离笼子中 对家庭微环境的持续监测促进了动物的福利， 职业安全和研究的重现性。最终，IVC减少了畜牧业 负担，从而鼓励有效地利用资源和分配时间。在大学里 密西西比州(UM)，教师招聘的增加和最近多种动物的增长 研究实验室导致了我们共享动物现代化的势头不断增强 设施。最近对校园啮齿动物研究团队的调查显示，对 在整个啮齿动物间隔膜设施中纳入静脉输液控制系统。这项提议的目标是 为了帮助满足动物研究团队的需求，在整个 我们共用隔间里的啮齿动物住房。办公室负责研究的副校长 研究完整性和合规性，以及机构动物保护和使用委员会 嗯，从调查人员、动物护理人员、外部顾问和我们的 认证机构评估所有动物的改良和现代化领域 校园内的住宅区。药学院和药学办公室内的行政单位 研究和赞助项目最近支持收购3 RAIR HD Super 来自LabProducts的鼠标750™IVC。这些系统的实施是 在微环境控制和动物和动物体征方面的直接和后续好处 研究人员的满意度是显而易见的。我们现在建议实施RAIR HD超级鼠标和 超级老鼠系统遍布所有的啮齿动物住房。我们的设施配备齐全，可满足 立即实施，无需翻新。现代化的呼声是进一步的 由与暖通空调和潜在过敏原相关的长期基础设施问题推动 在我们的设施内暴露，动物监督小组迅速和 从战略上讲。收购RAIR HD超级系统是我们战略行动的一个组成部分， 因为他们拥有额外的创新气流过滤技术，可以改善暖通空调负荷 和过敏原接触。因此，在我们的啮齿动物收容所中加入IVC将使我们能够 纠正长期存在的基础设施问题，防止多个潜在问题，并促进 在我们的动物研究项目中的效率。

Project Summary Utilization of individually-ventilated cage systems (IVCs) for housing rodents has become the industry standard across the fields of biomedical research. The combined approach of socially housing rodents in filter-topped, microisolator cages with tightly-controlled air exchange rates and continuous monitoring of the homecage microenvironment promotes animal welfare, occupational safety, and research reproducibility. Ultimately, IVCs reduce animal husbandry burdens thereby encouraging efficient resource utilization and time allocation. At the University of Mississippi (UM), increased faculty recruitment and the recent growth of multiple animal research laboratories has resulted in a rising momentum to modernize our shared use animal facilities. Recent surveys of rodent research teams on campus revealed a robust demand for the incorporation of IVCs throughout the rodent vivarium facility. The goal of this proposal is to help meet the needs of animal research teams by implementing IVCs throughout the rodent housing rooms in our shared-use vivarium. The Vice Chancellor for Research, Office of Research Integrity and Compliance, and the Institutional Animal Care and Use Committee at UM gathered feedback from investigators, animal care staff, external consultants, and our accrediting bodies to assess areas for improvement and modernization throughout all animal housing areas on campus. Administrative units within the School of Pharmacy and Office of Research and Sponsored Programs recently supported the acquisition of 3 RAIR HD Super Mouse 750™ IVCs from LabProducts. The implementation of these systems was straightforward and subsequent benefits in microenvironment control and signs of animal and researcher satisfaction are clear. We now propose to implement the RAIR HD Super Mouse and Super Rat systems throughout all rodent housing rooms. Our facility is fully-equipped for immediate implementation, with no renovations required. The call for modernization is further driven by standing infrastructure concerns relating to the HVAC and potential allergen exposures within our facility, which the animal oversight teams responding to swiftly and strategically. Acquisition of the RAIR HD Super systems is a component of our strategic actions, as they have additional innovative air flow filtration technologies that can improve HVAC burden and allergen exposure. Thus, incorporation of IVCs in our rodent housing facility will allow us to remediate standing infrastructure concerns, prevent multiple potential issues, and promote efficiency within our animal research program.