Acquisition of Individually Ventilated Cage Rack Systems for the University of Mississippi Vivarium

项目摘要 利用单独通风笼系统（IVC）饲养啮齿动物已成为 生物医学研究领域的行业标准。社会的综合方法 将啮齿类动物圈养在带有过滤器的微型隔离笼中，严格控制空气交换率 并且对家庭饲养场微环境的持续监测促进动物福利， 职业安全和研究再现性。最终，IVC减少了畜牧业 从而鼓励有效的资源利用和时间分配。大学 密西西比（UM），增加教师招聘和最近的多种动物的增长 研究实验室已经导致了一个不断增长的势头，以现代化我们的共享使用动物 设施最近对校园啮齿动物研究小组的调查显示， 在整个啮齿动物饲养设施中纳入IVC。这项提案的目的是 通过在整个国家实施IVC，帮助满足动物研究团队的需求 我们共用的动物园里的啮齿动物收容室研究副校长办公室 研究诚信和合规委员会和机构动物护理和使用委员会， UM从研究者、动物护理人员、外部顾问和我们的 授权机构评估所有动物的改进和现代化领域 校园内的住宅区。药学院和办公室内的行政单位 研究和赞助计划最近支持收购3 RAIR HD Super 来自LabProducts的小鼠750™ IVC。这些系统的实施是 在微环境控制和动物体征方面的直接和后续益处， 研究人员的满意度是明确的。我们现在建议实施RAIR HD超级鼠标， 所有啮齿动物饲养室都有超级老鼠系统。我们的设施齐全， 立即实施，无需翻新。现代化的呼声更进一步 由与HVAC和潜在过敏原相关的长期基础设施问题驱动 我们设施内的暴露，动物监督团队迅速作出反应， 战略性的收购RAIR HD Super系统是我们战略行动的一部分， 因为他们拥有额外的创新气流过滤技术，可以改善HVAC负担， 和过敏原暴露。因此，在我们的啮齿动物饲养设施中纳入IVC将使我们能够 解决长期存在的基础设施问题，预防多种潜在问题，并促进 在我们的动物研究项目中。

Project Summary Utilization of individually-ventilated cage systems (IVCs) for housing rodents has become the industry standard across the fields of biomedical research. The combined approach of socially housing rodents in filter-topped, microisolator cages with tightly-controlled air exchange rates and continuous monitoring of the homecage microenvironment promotes animal welfare, occupational safety, and research reproducibility. Ultimately, IVCs reduce animal husbandry burdens thereby encouraging efficient resource utilization and time allocation. At the University of Mississippi (UM), increased faculty recruitment and the recent growth of multiple animal research laboratories has resulted in a rising momentum to modernize our shared use animal facilities. Recent surveys of rodent research teams on campus revealed a robust demand for the incorporation of IVCs throughout the rodent vivarium facility. The goal of this proposal is to help meet the needs of animal research teams by implementing IVCs throughout the rodent housing rooms in our shared-use vivarium. The Vice Chancellor for Research, Office of Research Integrity and Compliance, and the Institutional Animal Care and Use Committee at UM gathered feedback from investigators, animal care staff, external consultants, and our accrediting bodies to assess areas for improvement and modernization throughout all animal housing areas on campus. Administrative units within the School of Pharmacy and Office of Research and Sponsored Programs recently supported the acquisition of 3 RAIR HD Super Mouse 750™ IVCs from LabProducts. The implementation of these systems was straightforward and subsequent benefits in microenvironment control and signs of animal and researcher satisfaction are clear. We now propose to implement the RAIR HD Super Mouse and Super Rat systems throughout all rodent housing rooms. Our facility is fully-equipped for immediate implementation, with no renovations required. The call for modernization is further driven by standing infrastructure concerns relating to the HVAC and potential allergen exposures within our facility, which the animal oversight teams responding to swiftly and strategically. Acquisition of the RAIR HD Super systems is a component of our strategic actions, as they have additional innovative air flow filtration technologies that can improve HVAC burden and allergen exposure. Thus, incorporation of IVCs in our rodent housing facility will allow us to remediate standing infrastructure concerns, prevent multiple potential issues, and promote efficiency within our animal research program.