2022 Hypothalamus Gordon Research Conference

项目摘要 我们组织了一个新的戈登研究会议（GRC）的主题下丘脑，一个高度 所有脊椎动物都有复杂的大脑结构。下丘脑对脊椎动物的生存至关重要， 由大量的神经元组成，这些神经元共同调节各种重要的生物学行为。 功能协调发展的下丘脑的失调与许多疾病状态有关，包括神经精神疾病。 疾病，睡眠障碍，饮食和代谢，生长/发育功能障碍，不孕不育，等等。 由于其对生物体生存的重要性，下丘脑是广泛研究的对象 跨越多个学科，使用不同的技术和各种模式生物。近年来， 科学家们在了解下丘脑的结构和功能方面取得了令人惊讶的进展， 产生了许多新的问题和调查领域，需要采取跨学科的办法。 本次会议的最终目标是将来自不同学科的科学家聚集在一起， 讨论新的见解，实验方法和最近的研究结果的治疗潜力。因为 下丘脑的复杂性是巨大的，科学家们研究下丘脑在多个层次， 调查我们的计划将有会议上的作用下丘脑在各种健康相关的 行为，包括摄食行为、睡眠和昼夜节律以及社会互动。其他会话 将重点放在下丘脑可塑性，解剖下丘脑细胞类型，下丘脑的调节， 神经内分泌系统，以及下丘脑和生物生理学之间的通信。采取 这一集合在一起，将使研究下丘脑的科学家们能够进行非凡的互动， 在许多生物学科中。至于所有的GRC，本次会议的指导原则将是 展示新的、未发表的结果，并进行自由、无障碍的讨论。我们将强调参与 所有职业层次的科学家，特别是博士生，博士后和初级教师，特别关注 促进多样性和包容性。

PROJECT SUMMARY We have organized a new Gordon Research Conference (GRC) on the topic of the hypothalamus, a highly complex brain structure found in all vertebrates. The hypothalamus is crucial for vertebrate survival and is composed of numerous small populations of neurons that collectively regulate a variety of important biological functions. Dysregulation of the hypothalamus is linked to a number of disease states including neuropsychiatric disorders, disorders of sleep, eating and metabolism, growth/development dysfunction, infertility, and more. Because of its importance for organismal survival, the hypothalamus is the subject of extensive investigation across multiple disciplines, using diverse techniques and in a variety of model organisms. In recent years, scientists have made surprising advances in understanding the structure and function of the hypothalamus that have generated many new questions and areas of investigation that require cross-disciplinary approaches. The ultimate goal of this conference is to bring scientists together from a variety of disciplines to share and discuss novel insights, experimental approaches, and therapeutic potential of recent findings. Because the complexity of the hypothalamus is enormous, scientists study the hypothalamus at multiple levels of investigation. Our program will have sessions on the role of the hypothalamus in a variety of health-related behaviors including ingestive behaviors, sleep and circadian rhythms, and social interactions. Other sessions will focus on hypothalamic plasticity, dissection of hypothalamic cell types, hypothalamic regulation of the neuroendocrine system, and communication between the hypothalamus and organismal physiology. Taken together, this GRC will allow for extraordinary interaction between scientists who study the hypothalamus across many biological disciplines. As for all GRCs, the guiding principle of this meeting will be the presentation of new, unpublished results with free, unencumbered discussion. We will emphasize participation of scientists at all career levels, especially PhD students, postdocs, and junior faculty, with a particular focus on promoting diversity and inclusion.